Conservation of dispersed paralogs # CDS1_name id % CDS2_name Protein family Short description CDS1 Short description CDS2 1 ZYRO0A04796g 100.0 ZYRO0A02200g GL3C019 highly similar to SACE YBR009C HHF1 and YNL030W HHF2, two identical histone H4 proteins Ê highly similar to SACE YBR009C HHF1 and YNL030W HHF2, two identical histone H4 proteins Ê 1 KLTH0G16236g 100.0 KLTH0G10692g 1 SAKL0C10714g 100.0 SAKL0E07304g 1 KLLA0E17601g 100.0 KLLA0E08647g 1 ERGO0E08624g 98.1 ERGO0D04664g 2 ZYRO0A04444g 97.7 ZYRO0A09702g GL3R0414 similar to SACE YBL002W HTB2 and YDR224C HTB1 , two nearly identical histone H2B proteins Ê similar to SACE YDR224C HTB1 and YBL002W HTB2, two nearly identical histone H2B proteins Ê 2 KLTH0G16500g 97.7 KLTH0E10186g 2 SAKL0C11242g 93.2 SAKL0H12694g 2 KLLA0E17337g 96.2 KLLA0F13310g 2 ERGO0E08316g 90.9 ERGO0G12452g 3 ZYRO0F04224g 71.7 ZYRO0C17754g GL3R0345 highly similar to SACE YPL004C LSP1 Long chain base-responsive inhibitor of protein kinases Phk1p and Phk2p Ê highly similar SACE YGR086C PIL1 Long chain base-responsive inhibitor of protein kinases Phk1p and Phk2p Ê 3 KLTH0A02288g 74.4 KLTH0D02992g 3 SAKL0B02750g 75.8 SAKL0B09328g 3 KLLA0E14411g 72.9 KLLA0F08162g 3 ERGO0G08228g 75.5 ERGO0E00462g 4 ZYRO0E05016g 70.8 ZYRO0B12496g GL3C0278 highly similar to SACE YLR174W IDP2 Cytosolic NADP-specific isocitrate dehydrogenase Ê highly similar SACE YDL066W IDP1 Mitochondrial NADP-specific isocitrate dehydrogenase Ê 4 KLTH0H12012g 72.4 KLTH0D14476g 4 SAKL0D08426g 74.0 SAKL0H02860g 4 KLLA0F12342g 73.9 KLLA0B03355g 4 ERGO0A03872g 71.0 ERGO0E09768g 5 ZYRO0G12936g 61.1 ZYRO0G11550g GL3C0373 highly similar to SACE YBR084W MIS1 Mitochondrial C1-tetrahydrofolate synthase similar to SACE YGR204W ADE3 Cytoplasmic trifunctional enzyme C1- tetrahydrofolate synthase Ê 5 KLTH0E14366g 65.3 KLTH0B01496g 5 SAKL0B06600g 65.1 SAKL0G14542g 5 KLLA0E12475g 62.0 KLLA0E16545g 5 ERGO0E12408g 62.3 ERGO0C02046g 6 ZYRO0A12518g 54.4 ZYRO0D06974g GL3R0183 highly similar to SACE YLR342W FKS1 Catalytic subunit of 1 3-beta-D- glucan synthase and SACE YGR032W GSC2 similar to SACE YMR306W FKS3 Protein of unknown function, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p Ê 6 KLTH0G17754g 55.2 KLTH0B09856g 6 SAKL0B04158g 58.2 SAKL0H00506g 6 KLLA0B05841g 57.3 KLLA0C14069g 6 ERGO0C00682g 56.5 ERGO0G00484g 7 ZYRO0E01012g 64.9 ZYRO0F08448g GL3C0249 Ê similar to SACE YKL081W TEF4 Translation elongation factor EF-1gamma Ê similar to SACE YPL048W CAM1 Translational cofactor elongation factor-1 gamma Ê 7 KLTH0C01342g 68.1 KLTH0E11572g 7 SAKL0G18964g 70.7 SAKL0H11154g 7 KLLA0F26092g 36.9 KLLA0D11594g 7 ERGO0D12760g 36.2 ERGO0G02596g 8 ZYRO0D16170g 52.9 ZYRO0B16038g GL3C0396 Ê highly similar to SACE YIL035C CKA1 alpha subunit of protein kinase CK2 Ê highly similar to SACE YOR061W CKA2 may have a role in regulation and/or execution of the eukaryotic cell cycle alpha' subunit of casein kinase II Ê 8 KLTH0A03542g 53.9 KLTH0F17490g 8 SAKL0F07854g 55.4 SAKL0G00990g 8 KLLA0E04247g 54.4 KLLA0F16467g 8 ERGO0D06908g 52.8 ERGO0D14036g 9 ZYRO0C17842g 48.5 ZYRO0B07458g GL3C0204 Ê similar to SACE YCR034W FEN1 Fatty acid elongase Ê similar to SACE YLR372W SUR4 Elongase III synthesizes 20-26-carbon fatty acids from C18-CoA primers Ê 9 KLTH0F03740g 51.2 KLTH0D13596g 9 SAKL0C04312g 54.3 SAKL0H03938g 9 KLLA0C03542g 54.0 KLLA0B07777g 9 ERGO0F20438g 53.9 ERGO0F19514g 10 ZYRO0C03454g 54.4 ZYRO0A11088g GL3C0320 Ê similar to SACE YNL328C MDJ2 Protein of the mitochondrial inner membrane Ê similar to SACE YLR008C PAM18 Constituent of the mitochondrial import motor Ê 10 KLTH0F19624g 51.6 KLTH0B02640g 10 SAKL0C13662g 57.4 SAKL0G12056g 10 KLLA0E02025g 48.6 KLLA0E09461g 10 ERGO0G17116g 50.0 ERGO0D17248g 11 ZYRO0D16346g 51.5 ZYRO0D03938g GL3C0488 Ê similar to SACE YER047C SAP1 Putative ATPase of the AAA family Ê similar to SACE YPL074W YTA6 Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family Ê 11 KLTH0A03696g 58.6 KLTH0E12562g 11 SAKL0F08008g 46.0 SAKL0H10032g 11 KLLA0E04379g 50.2 KLLA0E23409g 11 ERGO0D06776g 46.8 ERGO0E02618g 12 ZYRO0A04862g 49.5 ZYRO0G13662g GL3R0356 Ê highly similar to SACE YBR011C IPP1 Cytoplasmic inorganic pyrophosphatase Ê similar to SACE YMR267W PPA2 Mitochondrial inorganic pyrophosphatase Ê 12 KLTH0G16302g 51.3 KLTH0C04312g 12 SAKL0C10560g 49.1 SAKL0D02002g 12 KLLA0E17667g 49.1 KLLA0E11089g 12 ERGO0E08690g 47.5 ERGO0E14784g 13 ZYRO0C09086g 46.6 ZYRO0B13596g GL3C0405 Ê highly similar to SACE YIL078W THS1 Threonyl-tRNA synthetase cytoplasmic Ê similar to SACE YKL194C MST1 Mitochondrial threonyl-tRNA synthetase Ê 13 KLTH0A05192g 45.4 KLTH0D15620g 13 SAKL0F09614g 44.8 SAKL0G16698g 13 KLLA0F05918g 47.1 KLLA0D02772g 13 ERGO0C03938g 46.8 ERGO0E10780g 14 ZYRO0D17204g 46.1 ZYRO0F01650g GL3C0187 Ê similar to SACE YCR083W TRX3 mitochondrial thioredoxin Ê highly similar to gnl|GLV|CAGL0K00803g Candida glabrata CAGL0K00803g and similar to YLR043C uniprot|P22217 SACE YLR043C TRX1 thioredoxin Ê 14 KLTH0A07194g 44.9 KLTH0B01276g 14 SAKL0A00814g 57.1 SAKL0G14784g 14 KLLA0F10351g 47.5 KLLA0E16347g 14 ERGO0G03212g 33.0 ERGO0C01826g 15 ZYRO0A12958g 41.0 ZYRO0B03256g GL3C0490 Ê similar to SACE YBL064C PRX1 Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity Ê similar to SACE YBL064C PRX1 Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity Ê 15 KLTH0G17314g 45.6 KLTH0C06798g 15 SAKL0B04686g 47.7 SAKL0F12320g 15 KLLA0A02651g 44.6 KLLA0E20285g 15 ERGO0C00308g 42.2 ERGO0G16544g 16 ZYRO0B09812g 31.3 ZYRO0D16654g GL3C0506 Ê similar to SACE YNL111C CYB5 Cytochrome b5 Ê some similarities with SACE YNL111C CYB5 Cytochrome b5 Ê 16 KLTH0D09284g 38.2 KLTH0A04026g 16 SAKL0E10626g 48.3 SAKL0F08316g 16 KLLA0F23672g 46.0 KLLA0F27577g 16 ERGO0F00374g 46.6 ERGO0D07304g 17 ZYRO0G18898g 39.5 ZYRO0B07392g GL3R0412 Ê similar to SACE YJL174W KRE9 Glycoprotein involved in cell wall beta- glucan assembly Ê similar toSACE YJL174W KRE9 Glycoprotein involved in cell wall beta- glucan assembly Ê 17 KLTH0F04378g 38.0 KLTH0D13684g 17 SAKL0C04906g 47.2 SAKL0H03850g 17 KLLA0A06468g 49.1 KLLA0E01299g 17 ERGO0E05148g 35.4 ERGO0F19602g 18 ZYRO0G08140g 43.1 ZYRO0G14256g GL3C0447 Ê similar to SACE YPL184C Ê similar to SACE YML117W NAB6 Putative RNA-binding protein Ê 18 KLTH0H04906g 41.6 KLTH0C03784g 18 SAKL0A05280g 43.4 SAKL0D01364g 18 KLLA0E19031g 39.5 KLLA0D01485g 18 ERGO0F04048g 41.2 ERGO0B02068g 19 ZYRO0F01012g 36.7 ZYRO0G19140g GL3C0216 Ê similar to SACE YKL062W MSN4 and YMR037C MSN2 Transcriptional activators Ê weakly similar to SACE YER130C Ê 19 KLTH0D08734g 37.6 KLTH0E06688g 19 SAKL0B11330g 52.0 SAKL0H24816g 19 KLLA0F26961g 40.4 KLLA0C17072g 19 ERGO0B07194g 41.2 ERGO0C03498g 20 ZYRO0C11330g 41.3 ZYRO0G09966g GL3R0303 Ê similar to SACE YKL062W MSN4 and YMR037C MSN2 Transcriptional activators Ê highly similar to SACE YGL019W CKB1 beta (38kDa) subunit of protein kinase CK2 Ê 20 KLTH0F16852g 42.2 KLTH0E07590g 20 SAKL0G01672g 39.0 SAKL0H21692g 20 KLLA0E21869g 43.4 KLLA0A04818g 20 ERGO0C06776g 37.2 ERGO0G12012g 21 ZYRO0D02002g 45.8 ZYRO0E00836g GL3C0338 Ê similar to SACE YER020W GPA2 Nucleotide binding alpha subunit of the heterotrimeric G protein Ê similar to SACE YHR005C GPA1 GTP-binding alpha subunit of the heterotrimeric G protein Ê 21 KLTH0E01408g 35.6 KLTH0C01122g 21 SAKL0F14608g 45.1 SAKL0G19184g 21 KLLA0D10956g 29.6 KLLA0F25916g 21 ERGO0B08932g 44.1 ERGO0D12936g 22 ZYRO0F17402g 32.9 ZYRO0G03366g GL3C0403 Ê similar to SACE YDR507C Ê similar SACE YKL101W HSL1 Nim1p-related protein kinase Ê 22 KLTH0F01672g 39.9 KLTH0D05566g 22 SAKL0C01716g 42.2 SAKL0E02860g 22 KLLA0C01650g 36.0 KLLA0F13552g 22 ERGO0F22088g 45.1 ERGO0B04136g 23 ZYRO0C15774g 36.5 ZYRO0E00792g GL3C0385 Ê similar to SACE YBR091C MRS5 Essential protein of the inner mitochondrial membrane Ê similar to SACE YHR005C-A MRS11 Essential protein of the mitochondrial intermembrane space Ê 23 KLTH0E14872g 40.3 KLTH0C01078g 23 SAKL0B07194g 41.4 SAKL0G19228g 23 KLLA0B12034g 36.7 KLLA0F25872g 23 ERGO0D02178g 38.0 ERGO0D12980g 24 ZYRO0E01870g 37.8 ZYRO0A02838g GL3R0339 Ê similar to SACE YGL125W MET13 Isozyme of methylenetetrahydrofolate reductase Ê similar to SACE YPL023C MET12 Isozyme of methylenetetrahydrofolate reductase Ê 24 KLTH0H06446g 39.1 KLTH0E11022g 24 SAKL0A06952g 36.2 SAKL0H11836g 24 KLLA0F09647g 38.7 KLLA0D12188g 24 ERGO0A08602g 38.7 ERGO0F16544g 25 ZYRO0E07436g 34.8 ZYRO0C00704g GL3R0182 Ê similar to SACE YPL221W BOP1 Ê similar to SACE YAL053W Ê 25 KLTH0H03564g 38.0 KLTH0D00858g 25 SAKL0A03828g 38.5 SAKL0D14586g 25 KLLA0B01914g 41.4 KLLA0A03355g 25 ERGO0F02706g 37.5 ERGO0D18612g 26 ZYRO0F00924g 39.5 ZYRO0C02838g GL3C0223 Ê similar to SACE YKL064W Ê similar to SACE YOL130W ALR1 Plasma membrane Mg(2+) transporter and YFL050C ALR2 Probable Mg(2+) transporter Ê 26 KLTH0D08800g 37.7 KLTH0F19008g 26 SAKL0B11418g 36.6 SAKL0C12936g 26 KLLA0F26895g 38.5 KLLA0E07261g 26 ERGO0B07260g 36.8 ERGO0D05324g 27 ZYRO0B06776g 39.7 ZYRO0A09372g GL3C0451 Ê similar to SACE YNL281W HCH1 Heat shock protein regulator Ê similar to SACE YDR214W AHA1 Activator of Heat Shock Protein 90 ATPase Ê 27 KLTH0C09284g 37.3 KLTH0F07832g 27 SAKL0C09460g 35.1 SAKL0H13002g 27 KLLA0C12221g 36.4 KLLA0A04147g 27 ERGO0F13794g 38.5 ERGO0G06380g 28 ZYRO0G08624g 36.5 ZYRO0E04686g GL3R0352 Ê highly similar to SACE YGL076C RPL7A and YPL198W RPL7B Proteins component of the large (60S) ribosomal subunit Ê similar to SACE YNL002C Ê 28 KLTH0H04400g 34.9 KLTH0H12166g 28 SAKL0A04686g 33.0 SAKL0D08712g 28 KLLA0D03410g 45.2 KLLA0D04884g 28 ERGO0F03520g 36.0 ERGO0A04136g 29 ZYRO0C11946g 36.3 ZYRO0B04598g GL3C0266 Ê similar to SACE YNR036C Ê similar to SACE YGR118W RPS23A and YPR132W RPS23B Ribosomal proteins 28 (rp28) of the small (40S) ribosomal subunit Ê 29 KLTH0A07018g 37.5 KLTH0F14190g 29 SAKL0A00990g 37.5 SAKL0F03586g 29 KLLA0F07007g 38.8 KLLA0B11231g 29 ERGO0G03366g 35.2 ERGO0A07040g 30 ZYRO0A04598g 35.7 ZYRO0G02662g GL3R0316 Ê similar to SACE YBR002C RER2 Cis-prenyltransferase Ê similar to SACE YMR101C SRT1 Cis-prenyltransferase Ê 30 KLTH0G16390g 36.5 KLTH0D04906g 30 SAKL0C11132g 37.5 SAKL0E03476g 30 KLLA0E17205g 38.9 KLLA0B12848g 30 ERGO0E08404g 35.5 ERGO0B04422g 31 ZYRO0C05016g 34.0 ZYRO0G16742g GL3R0503 Ê similar to SACE YGL055W OLE1 Fatty acid desaturase Ê weakly similar to SACE YGL055W OLE1 Fatty acid desaturase Ê 31 KLTH0H06798g 36.0 KLTH0G06358g 31 SAKL0A07326g 39.5 SAKL0G10274g 31 KLLA0C05566g 37.4 KLLA0C10692g 31 ERGO0A08228g 34.5 ERGO0A02574g 32 ZYRO0D08096g 35.7 ZYRO0C11484g GL3R0209 Ê similar to SACE YNR034W (SOL1) and YCR073W-A (SOL2) Ê similar toSACE YHR163W SOL3 Glucose-6-phosphate dehydrogenase and YGR248W (SOL4) Ê 32 KLTH0A06864g 37.5 KLTH0H00836g 32 SAKL0A01166g 38.0 SAKL0H02376g 32 KLLA0C08415g 38.3 KLLA0A05390g 32 ERGO0E14432g 31.1 ERGO0E03256g 33 ZYRO0B14894g 29.3 ZYRO0A09416g GL3C0251 Ê similar to SACE YML081W Ê similar to SACE YDR216W ADR1 Positive transcriptional regulator controls the expression of ADH2 peroxisomal protein genes and genes required for ethanol glycerol and fatty acid utilization Ê 33 KLTH0D18062g 22.1 KLTH0E09922g 33 SAKL0G18062g 28.5 SAKL0H12958g 33 KLLA0B04477g 30.1 KLLA0F13046g 33 ERGO0E11946g 69.6 ERGO0G12210g 34 ZYRO0B06512g 32.3 ZYRO0C06776g GL3C0289 Ê similar to SACE YOL100W PKH2 Serine/threonine protein kinase Ê similar to SACE YDR466W PKH3 Protein kinase Ê 34 KLTH0C09548g 32.6 KLTH0G05214g 34 SAKL0C09174g 35.9 SAKL0G06402g 34 KLLA0C12485g 45.0 KLLA0E03587g 34 ERGO0F13530g 33.5 ERGO0F14520g 35 ZYRO0B09306g 33.7 ZYRO0B12650g GL3C0260 Ê highly similar to SACE YJL050W MTR4 Dead-box family ATP dependent helicase Ê similar to SACE YLR398C SKI2 blocks translation of non-poly(A) mRNAs antiviral protein putative helicase Ê 35 KLTH0H10406g 35.3 KLTH0D14630g 35 SAKL0D06622g 35.4 SAKL0H02706g 35 KLLA0F01364g 39.4 KLLA0B03179g 35 ERGO0E04070g 34.5 ERGO0E09900g 36 ZYRO0B16478g 37.1 ZYRO0F07326g GL3R0360 Ê similar to SACE YIL153W RRD1 Resistant to Rapamycin Deletion Ê similar to SACE YPL152W RRD2 Resistant to Rapamycin Deletion Ê 36 KLTH0E00880g 36.0 KLTH0D11176g 36 SAKL0E15070g 31.9 SAKL0H06622g 36 KLLA0A00462g 36.7 KLLA0F11187g 36 ERGO0F12518g 34.6 ERGO0C07964g 37 ZYRO0G11616g 33.6 ZYRO0G11088g GL3C0314 Ê similar to SACE YGR202C PCT1 Cholinephosphate cytidylyltransferase Ê similar to SACe YGR007W MUQ1 Choline phosphate cytidylyltransferase Ê 37 KLTH0B01584g 39.1 KLTH0E08712g 37 SAKL0G14476g 36.0 SAKL0H23012g 37 KLLA0E16611g 34.8 KLLA0C18139g 37 ERGO0C02112g 32.9 ERGO0F17622g 38 ZYRO0B05764g 35.1 ZYRO0D07172g GL3C0301 Ê similar to SACE YOL080C REX4 Putative RNA exonuclease Ê similar to SACE YGR276C RNH70 3' exoribonuclease Ê 38 KLTH0G15906g 33.7 KLTH0B09416g 38 SAKL0C10362g 35.4 SAKL0H01034g 38 KLLA0E17865g 34.4 KLLA0A10065g 38 ERGO0E08932g 37.6 ERGO0G00946g 39 ZYRO0D00990g 22.2 ZYRO0G01804g GL3C0440 Ê similar to SACE YPR182W SMX3 Sm or Sm-like snRNP protein Ê similar to SACE YDR378C LSM6 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay Ê 39 KLTH0A00770g 36.7 KLTH0F15620g 39 SAKL0F16082g 34.3 SAKL0G02904g 39 KLLA0E04929g 32.9 KLLA0E02575g 39 ERGO0E01892g 50.0 ERGO0C09438g 40 ZYRO0B14542g 36.0 ZYRO0D11000g GL3C0335 Ê some similarities with SACE YPL170W DAP1 Heme-binding protein involved in regulation of cytochrome P450 protein Ê highly similar to SACE YPL170W DAP1 Heme-binding protein involved in regulation of cytochrome P450 protein Ê 40 KLTH0D16566g 34.7 KLTH0D11836g 40 SAKL0G17732g 36.5 SAKL0H05918g 40 KLLA0B04796g 30.2 KLLA0C09757g 40 ERGO0E11638g 34.9 ERGO0A01936g 41 ZYRO0C07018g 34.6 ZYRO0E09570g GL3C0393 Ê highly similar to SACE YOR168W GLN4 Glutamine tRNA synthetase Ê highly similar to SACE YGL245W GUS1 Glutamyl-tRNA synthetase Ê 41 KLTH0C10340g 34.5 KLTH0G00682g 41 SAKL0E02134g 30.8 SAKL0F00748g 41 KLLA0F20449g 37.0 KLLA0A00682g 41 ERGO0G14124g 34.4 ERGO0F11880g 42 ZYRO0G15356g 31.0 ZYRO0E09086g GL3R0259 Ê similar to SACE YKR028W (SAP190) and YJL098W (SAP185) Ê similar to SACE YFR040W (SAP155) and YGL229C (SAP4) Ê 42 KLTH0D03388g 33.7 KLTH0G01144g 42 SAKL0D05456g 37.8 SAKL0F01320g 42 KLLA0F14124g 34.6 KLLA0A01155g 42 ERGO0F07590g 33.8 ERGO0F11462g 43 ZYRO0G20746g 32.7 ZYRO0B12254g GL3R0429 Ê similar to SACE YBR267W REI1 Ê similar to SACE YLR387C REH1 Ê 43 KLTH0H10758g 34.5 KLTH0D14212g 43 SAKL0D06996g 35.4 SAKL0H03190g 43 KLLA0F01727g 34.4 KLLA0E05171g 43 ERGO0E04422g 33.8 ERGO0E09504g 44 ZYRO0F04532g 35.0 ZYRO0C09856g GL3C0226 Ê highly similar to SACE YFR004W RPN11 Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid Ê similar to SACE YDL216C RRI1 subunit of COP9 signalosome Ê 44 KLTH0A02068g 35.2 KLTH0B07194g 44 SAKL0B03014g 31.4 SAKL0E13046g 44 KLLA0E14147g 33.0 KLLA0D08503g 44 ERGO0G08470g 34.1 ERGO0B01540g 45 ZYRO0B09702g 32.2 ZYRO0D09394g GL3C0257 Ê similar to YOR109w SACE INP53 Phosphatidylinositol 4,5-bisphosphate 5- phosphatase Ê similar to SACE YIL002C INP51 Phosphatidylinositol 4 5-bisphosphate 5- phosphatase Ê 45 KLTH0D09174g 34.3 KLTH0F13002g 45 SAKL0E10494g 35.3 SAKL0F04862g 45 KLLA0F23551g 30.7 KLLA0D13860g 45 ERGO0F00264g 34.0 ERGO0D09284g 46 ZYRO0D02354g 43.1 ZYRO0E08976g GL3C0413 Ê highly similar to SACE YNL052W (COX5A) and YIL111W (COX5B) Subunits Va and Vb of cytochrome c oxidase Ê similar to SACE YGL226W Ê 46 KLTH0G09746g 31.9 KLTH0G01254g 46 SAKL0E08360g 31.7 SAKL0F01430g 46 KLLA0F03641g 28.5 KLLA0A01298g 46 ERGO0D03674g 31.3 ERGO0F11352g 47 ZYRO0G20988g 33.9 ZYRO0E09262g GL3C0295 Ê similar to SACE YBR281C Ê highly similar to SACE YFR044C Ê 47 KLTH0H11000g 32.6 KLTH0G00990g 47 SAKL0D07238g 32.7 SAKL0F01100g 47 KLLA0F01991g 32.5 KLLA0A01001g 47 ERGO0E04664g 33.4 ERGO0F11616g 48 ZYRO0E02156g 35.0 ZYRO0F14388g GL3C0445 Ê similar to SACE YOR092W ECM3 Ê similar to SACE YLR152C Ê 48 KLTH0G08118g 35.0 KLTH0G11220g 48 SAKL0E10010g 33.4 SAKL0H14564g 48 KLLA0C13607g 31.6 KLLA0D17314g 48 ERGO0C02992g 29.9 ERGO0G04972g 49 ZYRO0F16676g 30.6 ZYRO0B16654g GL3C0361 Ê some similarities with SACE YNL271C BNI1 Formin nucleates the formation of linear actin filaments Ê some similarities with SACE YIL159W BNR1 Formin nucleates the formation of linear actin filaments Ê 49 KLTH0F02376g 33.2 KLTH0E00704g 49 SAKL0C02618g 35.1 SAKL0E15224g 49 KLLA0C02321g 30.3 KLLA0F10912g 49 ERGO0F21494g 35.1 ERGO0F12694g 50 ZYRO0D13772g 30.3 ZYRO0B12166g GL3C0450 Ê similar to SACE YML032C RAD52 Protein that stimulates strand exchange Ê similar to SACE YDL059C RAD59 Protein involved in the repair of double- strand breaks Ê 50 KLTH0G04862g 29.9 KLTH0D14124g 50 SAKL0G06072g 35.4 SAKL0H03278g 50 KLLA0B01782g 32.8 KLLA0E05259g 50 ERGO0E15290g 34.1 ERGO0E09416g 51 ZYRO0A04906g 32.7 ZYRO0C03058g GL3C0325 Ê similar to SACE YDL008W APC11 Catalytic core subunit of the Anaphase- Promoting Complex/Cyclosome (APC/C) Ê similar to SACE YOL133W HRT1 RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases Ê 51 KLTH0G16082g 32.3 KLTH0F19228g 51 SAKL0C10516g 35.8 SAKL0C13178g 51 KLLA0E17711g 29.9 KLLA0E07151g 51 ERGO0E08734g 30.9 ERGO0D05104g 52 ZYRO0D08514g 32.7 ZYRO0C09174g GL3C0436 Ê similar to SACE YCR059C YIH1 piecemeal microautophagy of the nucleus (PMN) Ê similar to SACE YDL177C Ê 52 KLTH0A06424g 31.7 KLTH0A05258g 52 SAKL0A01694g 31.9 SAKL0F09724g 52 KLLA0C08932g 34.0 KLLA0F05797g 52 ERGO0A05786g 30.1 ERGO0C04312g 53 ZYRO0B03762g 27.5 ZYRO0F14212g GL3C0283 Ê weakly similar to SACE YER112W LSM4 component of small nuclear ribonucleoprotein complexes involved in RNA processing, splicing, and decay Ê similar to SACE YLR147C SMD3 involved in snRNP biogenesis and pre-mRNA splicing encodes a core snRNP protein Ê 53 KLTH0C06248g 33.8 KLTH0G11396g 53 SAKL0F12892g 33.8 SAKL0H14740g 53 KLLA0E20813g 31.0 KLLA0D17160g 53 ERGO0G01738g 33.8 ERGO0G04796g 54 ZYRO0B01804g 32.3 ZYRO0E09284g GL3C0400 Ê highly similar to SACE YBR291C CTP1 Mitochondrial inner membrane citrate transporter Ê weakly similar to SACE YFR045W Ê 54 KLTH0D06622g 29.9 KLTH0G00968g 54 SAKL0A09284g 32.4 SAKL0F01078g 54 KLLA0E18723g 31.1 KLLA0A00979g 54 ERGO0G06952g 32.3 ERGO0F11638g 55 ZYRO0D11726g 27.8 ZYRO0A10582g GL3C0334 Ê highly similar to SACE YDR404C RPB7 RNA polymerase II subunit B16 Ê highly similar to SACE YKL144C RPC25 RNA polymerase III subunit C25 Ê 55 KLTH0G02926g 30.7 KLTH0G07546g 55 SAKL0G04048g 31.9 SAKL0G11506g 55 KLLA0C06787g 30.9 KLLA0E13751g 55 ERGO0F15114g 36.2 ERGO0C05896g 56 ZYRO0F02508g 31.3 ZYRO0D10406g GL3C0202 Ê similar to SACE YFL042C Ê similar to SACE YDR326C and YHR080C Ê 56 KLTH0G19030g 30.6 KLTH0E03806g 56 SAKL0B00770g 32.3 SAKL0G08404g 56 KLLA0D05555g 32.5 KLLA0E16919g 56 ERGO0B10582g 29.3 ERGO0D16082g 57 ZYRO0D15664g 29.2 ZYRO0D12298g GL3C0230 Ê highly similar to SACE YIL018W RPL2B and YFR031C-A RPL2A, Proteins of the large (60S) ribosomal subunit Ê similar to YEL050C SACE RML2 Mitochondrial ribosomal protein of the large subunit 57 KLTH0E04752g 32.1 KLTH0G03476g 57 SAKL0F07304g 29.1 SAKL0G04554g 57 KLLA0D16027g 31.4 KLLA0A02035g 57 ERGO0D06358g 30.9 ERGO0A07590g Ê 58 ZYRO0F02904g 27.1 ZYRO0D02508g GL3R0348 Ê similar to SACE YFL034C-B MOB2 Component of the RAM signaling network Ê similar to SACE YIL106W MOB1 Mps One Binder (putative) transcriptional regulator involved in mitosis Ê 58 KLTH0G18722g 29.6 KLTH0G09900g 58 SAKL0B01100g 30.7 SAKL0E08206g 58 KLLA0D05225g 31.1 KLLA0F03795g 58 ERGO0C09856g 33.1 ERGO0D03828g 59 ZYRO0G18568g 30.3 ZYRO0B03960g GL3C0265 Ê highly similar to SACE YKL170W MRPL38 Mitochondrial ribosomal protein of the large subunit Ê highly similar to SACE YER117W RPL23B and YBL087C RPL23A, components of the large (60S) ribosomal subunit Ê 59 KLTH0F04708g 27.9 KLTH0C06072g 59 SAKL0C05258g 30.3 SAKL0F13068g 59 KLLA0A06798g 31.6 KLLA0E06997g 59 ERGO0E05478g 31.5 ERGO0G01914g 60 ZYRO0F05566g 32.3 ZYRO0B15994g GL3C0473 Ê weakly similar to SACE YOR059C Ê similar to SACE YOR059C Ê 60 KLTH0C03102g 26.2 KLTH0F17446g 60 SAKL0D12100g 36.6 SAKL0G01034g 60 KLLA0F16709g 31.2 KLLA0F16423g 60 ERGO0F14740g 24.1 ERGO0D13992g 61 ZYRO0C12584g 30.0 ZYRO0D01914g GL3R0411 Ê similar to SACE YPR114W Ê similar to SACE YJR116W Ê 61 KLTH0E05566g 31.6 KLTH0E01320g 61 SAKL0F06292g 27.7 SAKL0F15180g 61 KLLA0D15059g 29.5 KLLA0D10868g 61 ERGO0A06468g 28.3 ERGO0B09020g 62 ZYRO0G20064g 29.6 ZYRO0F07216g GL3R0272 Ê similar to SACE YMR113W FOL3 Dihydrofolate synthetase involved in folic acid biosynthesis Ê similar to SACE YOR241W MET7 Folylpolyglutamate synthetase Ê 62 KLTH0D04664g 27.0 KLTH0D11066g 62 SAKL0E03872g 27.8 SAKL0H06732g 62 KLLA0B12463g 27.4 KLLA0F11297g 62 ERGO0E00990g 33.7 ERGO0C07854g 63 ZYRO0E07678g 29.0 ZYRO0D00968g GL3C0332 Ê similar to SACE YPL227C ALG5 UDP-glucose:dolichyl-phosphate glucosyltransferase Ê highly similar to SACE YPR183W DPM1 Dolichol phosphate mannose (Dol-P- Man) synthase of the ER membrane Ê 63 KLTH0H03256g 29.0 KLTH0A00748g 63 SAKL0A03542g 24.9 SAKL0F16104g 63 KLLA0C16071g 29.7 KLLA0B03377g 63 ERGO0F02420g 31.3 ERGO0E01870g 64 ZYRO0G06512g 22.7 ZYRO0A05676g GL3C0206 Ê similar to SACE YNL121C TOM70 Translocase of Outer Mitochondrial membrane Ê highly similar to SACE YOR027W STI1 Heat shock protein also induced by canavanine and entry into stationary phase Ê 64 KLTH0B05170g 27.6 KLTH0E02178g 64 SAKL0E10956g 29.9 SAKL0G07084g 64 KLLA0F24046g 40.0 KLLA0A07062g 64 ERGO0B08316g 22.6 ERGO0E03058g 65 ZYRO0D11462g 26.9 ZYRO0B08448g GL3R0438 Ê similar to SACE YOR147W MDM32 Mitochondrial Distribution and Morphology Ê highly similar to SACE YHR194W MDM31 Mitochondrial Distribution and Morphology Ê 65 KLTH0G02596g 28.7 KLTH0D17798g 65 SAKL0G03762g 29.7 SAKL0G18304g 65 KLLA0C06468g 31.0 KLLA0B04246g 65 ERGO0F14872g 24.7 ERGO0B03366g 66 ZYRO0B01540g 27.8 ZYRO0F06952g GL3C0212 Ê highly similar to SACE YHR001W OSH7 Member of an oxysterol-binding protein family Ê similar to SACE YPL145C KES1 Member of the oxysterol binding protein family Ê 66 KLTH0D06402g 28.6 KLTH0D10824g 66 SAKL0A08932g 27.5 SAKL0H06974g 66 KLLA0A02827g 28.4 KLLA0D07480g 66 ERGO0E01540g 27.5 ERGO0C07656g 67 ZYRO0F01078g 30.8 ZYRO0A08052g GL3C0337 Ê highly similar to SACE YMR035W IMP2 mitochondrial peptidase Ê similar to SACE YMR150c IMP1 protease, mitochondrial Ê 67 KLTH0D08668g 25.7 KLTH0H15884g 67 SAKL0B11264g 27.5 SAKL0E05478g 67 KLLA0F27027g 29.0 KLLA0F07293g 67 ERGO0B07128g 25.3 ERGO0D15488g 68 ZYRO0F16610g 27.8 ZYRO0C04356g GL3C0144 Ê similar to SACE YNL267W PIK1 Phosphatidylinositol 4-kinase Ê similar to SACE YLR240W VPS34 Phosphatidylinositol 3-kinase Ê 68 KLTH0F02442g 25.1 KLTH0F08404g 68 SAKL0C02750g 27.1 SAKL0H13596g 68 KLLA0C02387g 28.5 KLLA0D18645g 68 ERGO0F21428g 27.2 ERGO0G05896g 69 ZYRO0F17072g 27.4 ZYRO0G12276g GL3C0351 Ê similar to SACE YLR187W SKG3 and YNL278W CAF120 Part of the evolutionarily-conserved CCR4- NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation Ê weakly similar to SACE YJL016W Ê 69 KLTH0F02002g 26.3 KLTH0B02222g 69 SAKL0C02222g 30.8 SAKL0G13838g 69 KLLA0C01969g 28.3 KLLA0F22561g 69 ERGO0F21824g 22.8 ERGO0G15334g 70 ZYRO0G21736g 26.8 ZYRO0F11484g GL3C0293 Ê highly similar to SACE YGL100W SEH1 Nuclear pore protein homologous to Sec13p Ê highly similar to SACE YLR208W SEC13 Component of both the Nup84 nuclear pore sub-complex and of the COPII complex Ê 70 KLTH0H05610g 27.8 KLTH0H01518g 70 SAKL0A05962g 26.1 SAKL0F11022g 70 KLLA0F06754g 26.7 KLLA0C16643g 70 ERGO0F04598g 27.3 ERGO0C09328g 71 ZYRO0C09812g 27.3 ZYRO0A05962g GL3C0409 Ê some similarities with SACE YNL186W UBP10 Ubiquitin-specific protease Ê similar to SACE YMR223W UBP8 Ubiquitin-specific protease Ê 71 KLTH0B07150g 25.0 KLTH0D12760g 71 SAKL0E13002g 28.6 SAKL0H04994g 71 KLLA0D08459g 28.5 KLLA0C06974g 71 ERGO0B01562g 24.2 ERGO0F18678g 72 ZYRO0C10868g 27.8 ZYRO0F06710g GL3R0271 Ê similar to SACE YJL042W MHP1 Microtubule-associated protein Ê similar to SACE YPL137C and YOR227W Ê 72 KLTH0G07348g 24.9 KLTH0D10582g 72 SAKL0G11308g 27.2 SAKL0H07216g 72 KLLA0E11815g 28.2 KLLA0D07216g 72 ERGO0C06116g 24.4 ERGO0C07370g 73 ZYRO0B13266g 27.8 ZYRO0F07018g GL3R0319 Ê similar to SACE YKL188C PXA2 subunit of a peroxisomal ABC family long-chain fatty acid transporter Ê similar to SACE YPL147W PXA1 subunit of a peroxisomal ABC family long-chain fatty acid transporter Ê 73 KLTH0D15246g 27.7 KLTH0D10890g 73 SAKL0G16280g 24.9 SAKL0H06908g 73 KLLA0B02563g 26.2 KLLA0F11484g 73 ERGO0E10450g 25.7 ERGO0C07722g 74 ZYRO0A10472g 26.3 ZYRO0G10978g GL3R0252 Ê similar to SACE YBR168W PEX32 Peroxisomal integral membrane protein Ê similar to SACE YLR324W PEX30 Peroxisomal integral membrane protein Ê 74 KLTH0E13706g 27.1 KLTH0E08602g 74 SAKL0H08756g 26.9 SAKL0H22902g 74 KLLA0E24641g 23.9 KLLA0C18238g 74 ERGO0G13156g 26.5 ERGO0F17534g 75 ZYRO0F17204g 25.7 ZYRO0B03740g GL3C0149 Ê similar to SACE YLR182W SWI6 Transcription cofactor that regulate transcription at the G1/S transition Ê similar to SACE YER111C SWI4 Involved in cell cycle dependent gene expression transcription factor Ê 75 KLTH0F01826g 27.0 KLTH0C06270g 75 SAKL0C01914g 29.0 SAKL0F12870g 75 KLLA0C01826g 22.8 KLLA0E20791g 75 ERGO0F21956g 26.2 ERGO0G01716g 76 ZYRO0B03652g 25.7 ZYRO0A05632g GL3C0386 Ê highly similar to SACE YER107C GLE2 Component of the nuclear pore complex required for polyadenylated RNA export Ê similar to SACE YOR026W BUB3 Kinetochore checkpoint WD40 repeat protein Ê 76 KLTH0C06358g 27.4 KLTH0E02134g 76 SAKL0F12782g 24.7 SAKL0G07040g 76 KLLA0E20703g 25.7 KLLA0A07106g 76 ERGO0G01628g 26.8 ERGO0E03014g 77 ZYRO0B16544g 27.8 ZYRO0G06798g GL3C0217 Ê similar to SACE YIL156W UBP7 Ubiquitin-specific protease that cleaves ubiquitin-protein fusions Ê some similarities with SACE YDR069C DOA4 Ubiquitin hydrolase and YER144C UBP5 Putative ubiquitin-specific protease that does not associate with the proteasome Ê 77 KLTH0E00814g 27.9 KLTH0H07678g 77 SAKL0E15136g 24.8 SAKL0H18986g 77 KLLA0A00396g 22.9 KLLA0E10275g 77 ERGO0F12584g 26.1 ERGO0F05698g 78 ZYRO0C07502g 25.6 ZYRO0B09878g GL3C0326 Ê highly similar to SACE YOL005C RPB11 Ê similar to SACE YNL113W RPC19 RNA polymerase subunit common to RNA polymerases I and III Ê 78 KLTH0C10934g 23.3 KLTH0D09350g 78 SAKL0E01562g 28.4 SAKL0E10692g 78 KLLA0C06160g 26.1 KLLA0F23760g 78 ERGO0C04686g 25.6 ERGO0F00440g 79 ZYRO0D14124g 22.8 ZYRO0B13684g GL3C0384 Ê highly similar to SACE YLR268W SEC22 R-SNARE protein Ê highly similar to SACE YKL196C YKT6 v-SNARE (synaptobrevin) essential for endoplasmic reticulum-Golgi transport Ê 79 KLTH0G15510g 26.7 KLTH0D15708g 79 SAKL0A08492g 27.1 SAKL0G16786g 79 KLLA0F20251g 25.0 KLLA0D02684g 79 ERGO0G14300g 27.0 ERGO0E10868g 80 ZYRO0F05324g 26.8 ZYRO0D09570g GL3C0207 Ê similar to SACE YEL042W GDA1 Guanosine diphosphatase located in the Golgi Ê similar to SACE YER005W YND1 Yeast Nucleoside Diphosphatase Ê 80 KLTH0C03300g 25.7 KLTH0F13178g 80 SAKL0D11924g 26.8 SAKL0F04664g 80 KLLA0F16863g 25.4 KLLA0D13662g 80 ERGO0F14190g 23.6 ERGO0D09438g 81 ZYRO0F00880g 24.5 ZYRO0B12694g GL3C0404 Ê similar to SACE YKL065C YET1 Endoplasmic reticulum transmembrane protein Ê similar to SACE YDL072C YET3 Endoplasmic reticulum transmembrane protein Ê 81 KLTH0D08866g 24.2 KLTH0D14674g 81 SAKL0B11484g 28.3 SAKL0G15708g 81 KLLA0F26829g 25.0 KLLA0B03091g 81 ERGO0B07326g 25.2 ERGO0E09944g 82 ZYRO0C17886g 24.1 ZYRO0D01936g GL3C0317 Ê similar to SACE YCR036W RBK1 Putative ribokinase Ê similar to SACE YJR105W ADO1 adenosine kinase Ê 82 KLTH0F03696g 25.5 KLTH0E01342g 82 SAKL0C04268g 26.6 SAKL0F15158g 82 KLLA0C03498g 25.2 KLLA0D10890g 82 ERGO0F20482g 24.2 ERGO0B08998g 83 ZYRO0D08118g 22.9 ZYRO0B02970g GL3C0365 Ê similar to SACE YNR033W ABZ1 Ê similar to SACE YER090W TRP2 anthranilate synthase Component I Ê 83 KLTH0A06842g 25.0 KLTH0C07084g 83 SAKL0A01188g 26.7 SAKL0F12034g 83 KLLA0C08448g 27.6 KLLA0E19999g 83 ERGO0E14410g 22.8 ERGO0B10098g 84 ZYRO0A12452g 23.7 ZYRO0B01210g GL3C0344 Ê highly similar to SACE YLR340W RPP0 Conserved ribosomal protein P0 Ê highly similar to SACE YKL009W MRT4 Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus Ê 84 KLTH0G17820g 25.7 KLTH0D06050g 84 SAKL0B04092g 26.3 SAKL0E02288g 84 KLLA0B05918g 25.7 KLLA0B13563g 84 ERGO0C00748g 22.5 ERGO0B05148g 85 ZYRO0B07678g 32.4 ZYRO0B11132g GL3C0367 Ê similar to SACE YGR062C COX18 Ê similar to SACE YER154W OXA1 Translocase of the mitochondrial inner membrane Ê 85 KLTH0D13376g 30.8 KLTH0H07304g 85 SAKL0H04180g 20.0 SAKL0H18568g 85 KLLA0B08019g 18.6 KLLA0E00925g 85 ERGO0F19250g 21.7 ERGO0G11572g 86 ZYRO0G14190g 23.1 ZYRO0G02508g GL3C0231 Ê similar to SACE YMR278W Ê highly similar to SACE YMR105C PGM2 Phosphoglucomutase Ê 86 KLTH0C03872g 24.2 KLTH0D04796g 86 SAKL0D01474g 26.7 SAKL0E03630g 86 KLLA0D01573g 24.7 KLLA0B12694g 86 ERGO0B01980g 23.6 ERGO0B04268g 87 ZYRO0B03784g 25.0 ZYRO0C01848g GL3R0309 Ê similar to SACE YER113C Ê similar to SACE YLR083C EMP70 Protein whose 24kDa cleavage product is found in endosome-enriched membrane fractions Ê 87 KLTH0C06226g 23.7 KLTH0G13882g 87 SAKL0F12914g 24.0 SAKL0H17248g 87 KLLA0E20835g 25.5 KLLA0F18931g 87 ERGO0G01760g 22.1 ERGO0G10538g 88 ZYRO0E03652g 25.7 ZYRO0C09944g GL3C0372 Ê highly similar to SACE YEL013W VAC8 Phosphorylated vacuolar membrane protein Ê highly similar to SACE YNL189W SRP1 karyopherin alpha homolog of 60 kDa Ê 88 KLTH0H13926g 23.2 KLTH0B07282g 88 SAKL0D10736g 23.5 SAKL0E13134g 88 KLLA0A11286g 23.1 KLLA0D08580g 88 ERGO0E07172g 24.6 ERGO0B01452g 89 ZYRO0F04136g 23.0 ZYRO0B11836g GL3C0379 Ê similar to SACE YPL008W CHL1 Ê highly similar to SACE YER171W RAD3 5' to 3' DNA helicase subunit of Nucleotide Excision Repair Factor 3 and subunit of RNA polymerase II transcription initiation factor TFIIH Ê 89 KLTH0A02376g 23.6 KLTH0G14300g 89 SAKL0B02662g 25.2 SAKL0H17776g 89 KLLA0F27181g 24.3 KLLA0C17776g 89 ERGO0G08140g 23.5 ERGO0G10934g 90 ZYRO0D04554g 25.3 ZYRO0G01078g GL3C0390 Ê similar to SACE YAL035W FUN12 GTPase required for general translation initiation Ê similar to SACE YOL023W IFM1 Mitochondrial translation initiation factor 2 Ê 90 KLTH0D01606g 22.7 KLTH0H13530g 90 SAKL0B10758g 24.0 SAKL0D10274g 90 KLLA0F23265g 23.3 KLLA0A10923g 90 ERGO0D17886g 24.2 ERGO0E07546g 91 ZYRO0D01056g 24.3 ZYRO0G16962g GL3C0280 Ê highly similar to SACE YPR181C SEC23 cytoplasmic GTPase-activating protein Ê weakly similar to SACE YHR035W Ê 91 KLTH0A00814g 24.4 KLTH0G06138g 91 SAKL0F16038g 24.5 SAKL0G10010g 91 KLLA0E04885g 23.1 KLLA0C10461g 91 ERGO0E01936g 23.0 ERGO0A02794g 92 ZYRO0C09438g 24.4 ZYRO0G10934g GL3R0224 Ê highly similar to SACE YDL132W CDC53 Cullin structural protein of SCF complexes Ê similar to SACE YGR003W CUL3 Ê 92 KLTH0H02464g 20.8 KLTH0E08558g 92 SAKL0F10054g 23.6 SAKL0H22858g 92 KLLA0F05467g 24.2 KLLA0C18282g 92 ERGO0D11770g 26.2 ERGO0F17490g 93 ZYRO0B15400g 21.3 ZYRO0A13200g GL3C0228 Ê highly similar to SACE YHR148W IMP3 Component of the SSU processome Ê highly similar to SACE YPL081W RPS9A and YBR189W RPS9B, components of the small (40S) ribosomal subunit Ê 93 KLTH0C01958g 24.8 KLTH0E12826g 93 SAKL0G15268g 24.8 SAKL0H09768g 93 KLLA0E15995g 24.8 KLLA0E23673g 93 ERGO0D06270g 22.5 ERGO0E02376g 94 ZYRO0C05544g 27.5 ZYRO0B01298g GL3C0366 Ê similar to SACE YNR006W VPS27 hydrophilic protein has cysteine rich putative zinc finger Ê similar to SACE YHL002W HSE1 Subunit of the endosomal Vps27p-Hse1p complex Ê 94 KLTH0A05676g 19.5 KLTH0D06138g 94 SAKL0A02464g 28.4 SAKL0E02200g 94 KLLA0F06446g 18.8 KLLA0B13475g 94 ERGO0F01430g 23.8 ERGO0B05060g 95 ZYRO0C03256g 24.4 ZYRO0C09306g GL3C0299 Ê similar to SACE YNL321W Protein of unknown function potential Cdc28p substrate Ê similar to SACE YDL128W VCX1 Ê 95 KLTH0F19404g 24.4 KLTH0A05368g 95 SAKL0C13398g 22.4 SAKL0F09878g 95 KLLA0E21033g 22.5 KLLA0F05632g 95 ERGO0D04928g 24.2 ERGO0F09350g 96 ZYRO0A04378g 23.4 ZYRO0C03718g GL3C0222 Ê similar to SACE YDL002C NHP10 likely component of the INO80, ATP-dependent chromatin-remodeling complex Ê similar to SACE YDR174W HMO1 Chromatin associated high mobility group (HMG) Ê 96 KLTH0G16566g 24.1 KLTH0F09020g 96 SAKL0C11308g 21.9 SAKL0H14234g 96 KLLA0E17403g 22.0 KLLA0D18029g 96 ERGO0E08250g 26.3 ERGO0G05280g 97 ZYRO0G01166g 23.7 ZYRO0G16852g GL3C0354 Ê highly similar to SACE YOL021C DIS3 Nucleolar exosome component involved in rRNA processing and RNA degradation Ê similar to SACE YDR293C SSD1 Protein that interacts with components of the TOR pathway 97 KLTH0H13420g 24.8 KLTH0G06248g 97 SAKL0D10186g 22.9 SAKL0G10142g 97 KLLA0A10835g 23.0 KLLA0C10571g 97 ERGO0E07634g 22.9 ERGO0A02706g Ê 98 ZYRO0A02068g 22.0 ZYRO0F13046g GL3C0388 Ê highly similar to SACE YNL025C SSN8 Component of RNA polymerase II holoenzyme involved in RNA pol II carboxy-terminal domain phosphorylation Ê similar to SACE YPR025C CCL1 Cyclin associated with protein kinase Kin28p which is the TFIIH-associated carboxy-terminal domain (CTD) kinase 98 KLTH0G10560g 24.4 KLTH0C05720g 98 SAKL0E07480g 25.3 SAKL0F13398g 98 KLLA0E08163g 24.4 KLLA0E06689g 98 ERGO0D04532g 20.6 ERGO0G02244g Ê 99 ZYRO0F07964g 23.1 ZYRO0D12694g GL3C0442 Ê similar to SACE YDL113C ATG20 Protein required for transport of aminopeptidase I (Lap4p) through the cytoplasm-to-vacuole targeting pathway Ê similar to SACE YDR425W SNX41 Sorting nexin that mediates retrieval from endosomes Ê 99 KLTH0F09328g 24.1 KLTH0G03894g 99 SAKL0E06710g 22.3 SAKL0G05060g 99 KLLA0E09175g 23.6 KLLA0B00803g 99 ERGO0D02574g 23.3 ERGO0D13772g 100 ZYRO0D04972g 22.8 ZYRO0B14344g GL3C0381 Ê similar to SACE YAL042W ERV46 Protein localized to COPII-coated vesicles forms a complex with Erv41p Ê similar to SACE YML067C ERV41 Protein in COPII-coated vesicles Ê 100 KLTH0D01144g 29.7 KLTH0D16324g 100 SAKL0D14234g 19.0 SAKL0G17512g 100 KLLA0C12947g 22.3 KLLA0B04950g 100 ERGO0D18238g 22.3 ERGO0E11462g 101 ZYRO0C14674g 25.1 ZYRO0G13112g GL3C0248 Ê similar to SACE YBR233W PBP2 Ê similar to SACE YBL032W HEK2 Ê 101 KLTH0H06050g 26.2 KLTH0E14520g 101 SAKL0A06424g 19.1 SAKL0B06798g 101 KLLA0F10703g 20.4 KLLA0E12321g 101 ERGO0F05038g 22.3 ERGO0E12584g 102 ZYRO0D16368g 26.4 ZYRO0C03960g GL3C0263 Ê similar to SACE YIL039W Ê similar to SACE YDR182W CDC1 Putative membrane protein of unknown function involved in Mn2 homeostasis Ê 102 KLTH0A03718g 22.1 KLTH0F08800g 102 SAKL0F08030g 21.9 SAKL0H13992g 102 KLLA0E04401g 22.2 KLLA0D18238g 102 ERGO0D06754g 20.0 ERGO0G05500g 103 ZYRO0F09482g 23.0 ZYRO0A13354g GL3C0380 Ê similar to SACE YOR275C RIM20 Protein involved in proteolytic activation of Rim101p in response to alkaline pH, member of the PalA/AIP1/Alix family Ê similar to SACE YPL084W BRO1 Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body pathway by recruiting Doa4p to endosomes Ê 103 KLTH0D12408g 25.2 KLTH0E13002g 103 SAKL0H05346g 20.9 SAKL0H09614g 103 KLLA0C07348g 19.6 KLLA0E23871g 103 ERGO0E16104g 23.6 ERGO0G12914g 104 ZYRO0A05940g 20.5 ZYRO0C04004g GL3C0422 Ê similar to SACE YOR281C PLP2 Ê similar to SACE YDR183W PLP1 Ê 104 KLTH0D12782g 21.9 KLTH0F08756g 104 SAKL0H04972g 22.0 SAKL0H13948g 104 KLLA0C06952g 23.7 KLLA0D18282g 104 ERGO0F18700g 23.0 ERGO0G05544g 105 ZYRO0B13750g 20.5 ZYRO0B07480g GL3C0290 Ê similar to SACE YLR425W TUS1 Guanine nucleotide exchange factor (GEF) Ê similar to SACE YLR371W ROM2 GDP/GTP exchange protein Ê 105 KLTH0D15752g 23.2 KLTH0D13574g 105 SAKL0G16874g 23.0 SAKL0H03960g 105 KLLA0D02618g 22.0 KLLA0B07799g 105 ERGO0E10890g 22.1 ERGO0F19492g 106 ZYRO0D11110g 17.2 ZYRO0B14454g GL3C0448 Ê similar to SACE YDR388W RVS167 BAR adaptor protein subunit of a complex (Rvs161p- Rvs167p) that regulates actin endocytosis Ê some similarities with SACE YDR388W RVS167 BAR adaptor protein, subunit of a complex (Rvs161p-Rvs167p) that regulates actin endocytosis Ê 106 KLTH0F15114g 18.1 KLTH0D16434g 106 SAKL0G03454g 27.3 SAKL0G17600g 106 KLLA0E03059g 25.0 KLLA0B04862g 106 ERGO0F08888g 21.7 ERGO0E11550g 107 ZYRO0D11616g 26.5 ZYRO0B08514g GL3C0420 Ê similar to SACE YDR398W UTP5 Nucleolar protein component of the small subunit (SSU) processome Ê similar to SACE YHR196W UTP9 Nucleolar protein component of the small subunit (SSU) processome Ê 107 KLTH0G02772g 22.4 KLTH0D17732g 107 SAKL0G03916g 20.8 SAKL0G18370g 107 KLLA0C06633g 18.4 KLLA0B04180g 107 ERGO0F15026g 20.9 ERGO0B03300g 108 ZYRO0A02420g 20.2 ZYRO0D03982g GL3C0358 Ê similar to SACE YDL122W UBP1 Ubiquitin-specific protease Ê weakly similar to SACE YPL072W UBP16 Putative ubiquitin-specific protease Ê 108 KLTH0G10934g 20.7 KLTH0E12540g 108 SAKL0E07106g 22.8 SAKL0H10076g 108 KLLA0E08801g 22.4 KLLA0E23387g 108 ERGO0G17028g 22.0 ERGO0E02662g 109 ZYRO0F16500g 19.3 ZYRO0C10516g GL3C0318 Ê similar to SACE YGL140C Ê similar to SACE YDL231C BRE4 Zinc finger protein containing five transmembrane domains Ê 109 KLTH0F02552g 21.6 KLTH0B07810g 109 SAKL0C02860g 20.5 SAKL0E13684g 109 KLLA0C02497g 23.8 KLLA0D19118g 109 ERGO0F21318g 19.5 ERGO0B00990g 110 ZYRO0G01584g 20.8 ZYRO0B12122g GL3C0247 Ê similar to SACE YOL034W SMC5 Structural maintenance of chromosomes protein Ê similar to SACE YLR383W RHC18 Protein involved in structural maintenance of chromosomes required for interchromosomal and sister chromatid recombination Ê 110 KLTH0D02816g 20.2 KLTH0D14080g 110 SAKL0B09526g 20.6 SAKL0H03322g 110 KLLA0F07997g 22.8 KLLA0E05303g 110 ERGO0E00286g 19.5 ERGO0E09372g 111 ZYRO0D01100g 18.6 ZYRO0G16940g GL3C0425 Ê similar to SACE YPR179C HDA3 Subunit of a possibly tetrameric trichostatin A- sensitive class II histone deacetylase complex Ê similar to SACE YDR295C HDA2 Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex Ê 111 KLTH0A00858g 21.0 KLTH0G06160g 111 SAKL0F15994g 19.2 SAKL0G10032g 111 KLLA0E04841g 17.1 KLLA0C10483g 111 ERGO0E01980g 26.7 ERGO0A02772g 112 ZYRO0B03278g 19.5 ZYRO0D01650g GL3C0256 Ê similar to SACE YBL066C SEF1 putative transcription factor Ê similar to SACE YLR451W LEU3 Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation Ê 112 KLTH0C06776g 19.2 KLTH0F18392g 112 SAKL0F12342g 20.3 SAKL0F15444g 112 KLLA0E20307g 20.2 KLLA0D10593g 112 ERGO0G16566g 22.6 ERGO0B09284g 113 ZYRO0D02662g 20.4 ZYRO0B13442g GL3C0347 Ê highly similar to SACE YIL103W DPH1 Protein required along with Dph2p Kti11p Jjj3p and Dph5p for synthesis of diphthamide Ê similar to SACE YKL191W DPH2 Protein required along with Dph1p Kti11p Jjj3p and Dph5p for synthesis of diphthamide Ê 113 KLTH0G10054g 20.2 KLTH0D15422g 113 SAKL0E08030g 20.7 SAKL0G16500g 113 KLLA0F03971g 19.5 KLLA0D02948g 113 ERGO0D03982g 20.6 ERGO0E10604g 114 ZYRO0C10340g 22.4 ZYRO0F09988g GL3C0362 Ê similar toSACE YNL207W RIO2 Protein required for cell viability Ê similar to SACE YOR119C RIO1 Essential protein that plays a role in cell cycle progression Ê 114 KLTH0B07722g 20.7 KLTH0F16104g 114 SAKL0E13552g 18.9 SAKL0G02486g 114 KLLA0D19008g 19.3 KLLA0E21121g 114 ERGO0B01100g 19.9 ERGO0E14168g The table indicates the series of pairs of paralogs in which both members are conserved among the five protoploid yeast species. For all series (number in column 1, classified by decreasing values of sequence conservation) are indicated the two genes concerned (columns 2 and 4), the % of amino-acid identity of their products (column 3) and the corresponding protein family (column 5). For each series, the five genes listed vertically are orthologs confirmed by synteny, and their short description is given by columns 6 and 7. 1