Conservation and specificity of tandem gene arrays (TGAs) protein_family ZYRO KLTH SAKL KLLA ERGO short description Conserved, syntenic TGAs GL3C0004 (TGA #1) 2 2 4 2 2 similar to SACE YEL063C CAN1 Plasma membrane arginine permease and SACE YNL268W LYP1 Lysine permease GL3C0004 (TGA #2) 2 2 3 2 3 similar to SACE YKR039W GAP1 General amino acid permease and YDR508C GNP1 High-affinity glutamine permease GL3C0007 (TGA #1) 4 2 2 1+p similar to SACE YNL065W AQR1 Plasma membrane transporter of the major facilitator superfamily ; YIL121W QDR2 Multidrug transporter ; YBR008C FLR1 Plasma membrane multidrug transporter member of the major facilitator superfamily GL3C0007 (TGA #2) 2 2 highly similar to SACE YNR055C GL3C0014 2 2 2 2 similar to SACE YMR170C ALD2 Cytosolic aldehyde dehydrogenase; YMR170c ALD5 ; YMR169c ALD4 GL3C0019 2 2 2 highly similar to SACE YDL192W ARF1 and YDL137W ARF2, ADP-ribosylation factor GTPases of the Ras superfamily GL3C0047 (1) 2 2 2 2 2 similar to SACE YOR130C ORT1 Ornithine transporter of the mitochondrial inner membrane; weakly similar to SACE YEL006W Hypothetical ORF GL3C0073 2 2 similar to SACE YOL119C MCH4 Protein with similarity to mammalian monocarboxylate permeases GL3C0142 3 3 2 3 2 similar to SACE YKL164C PIR1 Protein containing tandem internal repeats GL3C0156 2 2 2 weakly similar to SACE YJR061W; YKL201C MNN4 Putative positive regulator of mannosylphosphate transferase GL3C0177 2 2 2 similar to SACE YLR414C; weakly similar to YKL187C and YLR413W GL3C0235 (2) 3 3 3 some similarities with SACE YOL048c and YAL018c GL3C0480 2 2 2 2 2 similar to SACE YPL129W TAF14 Subunit of TFIID, TFIIF and SWI/SNF complexes of trancription GL3C0507 2 2 some similarities with SACE YDR003W GL3C2661 (3) 2 2 2 2 2 similar to SACE YAR018C KIN3 Nonessential protein kinase; YAR019C CDC15 Protein kinase of the Mitotic Exit Network GL3R0042 2 2 2 2 similar to SACE YMR307W GAS1 Beta-1.3-glucanosyltransferase GL3R0210 2 2 similar to SACE YMR222C FSH2 Serine hydrolase GL3R0439 2 2 2 2 2 similar to SACE YOR285W; YOR286W FMP31 Conserved TGAs without clearcut syntenic conservation GL3C0002 2 2 2 3 similar to SACE High-affinity and low-affinity glucose transporters of the major facilitator superfamily GL3C0003 2 2 2 2 similar to SACE YPR165W RHO1 GTP-binding protein GL3C0005 2 2 2 2 similar to SACE YAL060W BDH1 NAD-dependent (2R 3R)-2 3-butanediol dehydrogenase; YAL061W putative polyol dehydrogenase; YMR152W; YNL134C; YMR083W ADH3 GL3C0009 2 2 similar to SACE YPR198W SGE1 Member of drug-resistance protein family GL3C0012 5 2 similar to SACE YIL015W BAR1 Aspartyl protease; YLR121C YPS3 Aspartic protease; YLR120C YPS1 Aspartic protease; YDR144C MKC7 GPI- anchored aspartyl protease (yapsin) ; YIR039C YPS6 Putative GPI-anchored aspartic protease; YPL154C (PEP4) GL3C0018 (TGA #1) 2 3 3 Similar to SACE YAL051W (OAF1) and YOR363C (PIP2) GL3C0018 (TGA #2) 2 Similar to SACE YAL051W (OAF1) and YOR363C (PIP2) GL3C0018 (TGA #3) 2 Similar to SACE YAL051W (OAF1) and YOR363C (PIP2) GL3C0025 (TGA #1) 3 2 2 2 similar to SACE YDR011W SNQ2 ABC transporter; YOR153W PDR5 Short-lived membrane ABC transporter; YDR406W PDR15 ABC transporter GL3C0025 (TGA #2) 2 highly similar to SACE YPL058C PDR12 ABC transporter GL3C0028 2 2 2 2 2 similar to SACE YPR119W CLB2 B-type cyclin and YGR108W CLB1; YPR120C CLB5 B-type cyclin and YGR109C CLB6 GL3C0031 (6) 1+p 2 weakly similar to SACE YHL048W COS8 GL3C0031 (6) 2 1+p 2 weakly similar to SACE YGR295C COS6; some similarities with SACE YFL062W COS4 GL3C0031 (6) 4 some similarities with SACE YKL219W COS9 GL3C0031 (6) 1+p weakly similar to SACE YFL062W COS4 GL3C0031 (6) 1+p weakly similar to SACE YML132W COS3 GL3C0031 (6) 1+p 1+p weakly similar to SACE YNL336W COS1 and YJR161C COS5 GL3C0031 (6) 1+p 2 some similarities with SACE YNL336W COS1 and YJR161C COS5 GL3C0039 1+p 4 weakly similar to SACE YOR381W FRE3 Ferric reductase; YOR384W FRE5 Putative ferric reductase GL3C0080 2 2 highly similar to SACE YHR179W OYE2 NADPH oxidoreductase GL3C0170 2 2 2 2 some similarities with SACE YJL079C PRY1 and YKR013W PRY2, proteins of unknown function GL3C0377 2 1+p similar to SACE YKL222C and YOR172W GL3C0443 (4) 3 2 2 4 some similarities with SACE YKL096W CWP1 Cell wall mannoprotein GL3C0536 2 2 some similarities with SACE YIL119C RPI1 Putative transcriptional regulator GL3M4590 (5) (6) 1+p 2 2 some similarities with SACE YAR050W FLO1 Lectin-like protein; YAL063C; YHR211W FLO5 GL3M4590 (5) (6) 1+p some similarities with SACE YAR050W FLO1 Lectin-like protein involved in flocculation GL3R0054 2 2 1+p similar to SACE YJL212C OPT1 Plasma membrane transporter; YPR194C OPT2 Oligopeptide transporter GL3R0082 2 2 similar to SACE YDR384C ATO3 Plasma membrane protein; YCR010C ADY2 and YNR002C FUN34, members of the TC 9.B.33 YaaH family of putative transporters GL3R0103 1+p 2 similar to SACE YMR008C PLB1 Phospholipase B (lysophospholipase) Species-specific TGAs GL3C0684 1 conserved hypothetical protein GL3R0233 2 no similarity GL3R0426 2 similar SACE YER175C TMT1 Trans-aconitate methyltransferase GL3C3802 2 some similarities with SACE YML111W BUL2 Component of the Rsp5p E3- ubiquitin ligase complex GL3R0461 2 similar to SACE YPR159W KRE6 Protein required for beta-1 6 glucan biosynthesis GL3C0670 2 similar to SACE YBR229C ROT2 Glucosidase II catalytic subunit GL3R3311 2 similar to SACE YBR058C-A TSC3 involved in sphingolipid biosynthesis GL3C0695 2 some similarites with SACE YMR043W MCM1 Transcription factor GL3C0470 2 weakly similar to SACE YOR385W GL3C3673 2 some similarities with SACE YIR019C MUC1 GPI-anchored cell surface glycoprotein GL3C0501 2 similar to SACE YOR180C DCI1 Peroxisomal delta(3 5)-delta(2 4)-dienoyl-CoA isomerase GL3C0141 2 similar to SACE YPL140C MKK2 Mitogen-activated kinase kinase --- 2 no similarity GL3R0233 3 no similarity GL3R3887 1 conserved hypothetical protein --- 1 no similarity GL3C0196 2 similar to SACE YER062C HOR2 and YIL053W RHR2, two redundant DL-glycerol-3-phosphatases GL3C3719 2 conserved hypothetical protein GL3R0092 2 weakly similar to SACE YDL078C MDH3 Cytoplasmic malate dehydrogenase GL3C0059 2 no similarity GL3R4018 3 no similarity GL3R3887 3 conserved hypothetical protein GL3C0078 5 some similarities with SACE YBL017C PEP1 Type I transmembrane sorting receptor ; YJL222W GL3R2229 1 similar to SACE YCR046C IMG1 Mitochondrial ribosomal protein GL3R3075 1 conserved hypothetical protein GL3R2318 2 similar to SACE YGL067W NPY1 NADH diphosphatase GL3C0179 2 similar to SACE YMR234W RNH1 Ribonuclease H1 GL3C0482 2 similar to SACE YJL171C GL3C3800 2 similar to SACE YJL151C SNA3 Integral membrane protein GL3C4417 2 no similarity GL3C0410 2 weakly similar to Candida glabrata CAGL0B02926g GL3C0193 2 some similarities with SACE YER057C HMF1 Member of the p14.5 protein family GL3C0110 2 similar to SACE YBL042C FUI1 High affinity uridine permease GL3M4603 (7) 2 weakly similar to SACE YPR015C GL3C0220 2 highly similar to SACE YBR299W MAL32 Maltase (alpha-D-glucosidase) GL3C3541 2 conserved hypothetical protein GL3C0110 2 highly similar to Kluyveromyces lactis KLLA0C19415g; similar to SACE YOR192C GL3C0368 2 highly similar to Kluyveromyces lactis KLLA0A03553g; similar to SACE YAL046C GL3C4478 3 some similarities with SACE YJL047C RTT101 Cullin family member subunit of a complex containing ubiquitin ligase activity GL3R0920 1 conserved hypothetical protein GL3R1456 2 some similarities SACE YGR268C HUA1 GL3C3203 2 some similarities with SACE YGL262W GL3C3205 2 some similarities with SACE YBR250W GL3C0667 2 some similarities with SACE YDR514C GL3R0524 2 highly similar to SACE YDR533C GL3R0152 2 similar to SACE YNL142W MEP2 Ammonium permease GL3C0055 2 similar to SACE YGL039W; YGL157W; YOL151W; YDR541C NADPH- dependent Oxidoreductases GL3C1579 2 some similarities with SACE YMR265C GL3C4098 2 some similarities with ACE YKL096W CWP1 Cell wall mannoprotein GL3C0369 2 similar to SACE YJL092W HPR5 DNA helicase GL3C0011 2 highly similar to SACE YGL008C PMA1 Plasma membrane H -ATPase GL3C0001 2 similar to SACE YDR243C PRP28 RNA helicase in the DEAD-box family; YGL078C DBP3 Putative ATP-dependent RNA helicase of the DEAD-box family GL3C3549 2 some similarities with SACE YOR383C GL3R0782 2 Similar to SACE YDL237W GL3C4074 2 No homolog in SACE GL3R0860 2 Similar to SACE YLR215C CDC123 GL3C0306 2 Similar to SACE YGL246C RAI1 GL3C0190 2 Similar to SACE YJL172W CPS1 GL3C1032 2 Similar to SACE YCL057W PRD1 GL3C4268 2 No homolog in SACE GL3R0174 3 Similar to SACE YMR238W DFG5 GL3R0084 3 Similar to SACE YJR107W GL3C0008 4 Similar to SACE YIR035C; YIR036C The table indicates, for each yeast species (columns 2-6), the number of genes present in each TGA (p: pseudogene). TGAs were classified according to protein families and conserved synteny. Additional family relationships are: (1) members in GL3C0486 family; (2) members in GL3C4053 family; (3) members in GL3C2716 family; (4) members in GL3C4401, GL3U4586, GL3M4608 and GL3M4617 families; (5) members in GL3C3528 and GL3M4610 families; (6) complex subtelomeric locations; (7) members in GL3C3788 family.