Family		GL3R3440, 7 members
Phyletic pattern		s-zlt-gdy
Phylogen. profile		1 0 1 1 1 0 1 1 1
Proteins		SACE0B00440p ZYRO0F13002p SAKL0F13332p KLTH0C05786p ERGO0G02178p DEHA2C05984p YALI0D09867p

Family relations  

Proteins in GL3R3440  

SACE0B00440p	Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease
ZYRO0F13002p	similar to uniprot|P38169 Saccharomyces cerevisiae YBL098W BNA4 Kynurenine 3-mono oxygenase required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway
SAKL0F13332p	similar to uniprot|P38169 Saccharomyces cerevisiae YBL098W BNA4 Kynurenine 3-mono oxygenase required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway
KLTH0C05786p	similar to uniprot|P38169 Saccharomyces cerevisiae YBL098W BNA4 Kynurenine 3-mono oxygenase required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway
ERGO0G02178p	Syntenic homolog of Saccharomyces cerevisiae YBL098W (BNA4)
DEHA2C05984p	similar to uniprot|P38169 Saccharomyces cerevisiae YBL098w BNA4 Kynurenine 3-mono oxygenase
YALI0D09867p	similar to uniprot|P38169 Saccharomyces cerevisiae YBL098w related to kynurenine 3-monooxygenase

Gene Ontology terms  

GO:0034354	de novo NAD biosynthetic process
GO:0016491	oxidoreductase activity
GO:0008152	metabolic process
GO:0005741	mitochondrial outer membrane
GO:0005515	protein binding
GO:0004502	kynurenine 3-monooxygenase activity

Data  

Pairwise distances

Amino-acid sequences

Multiple sequence alignment

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Legend and notes  

Type of family, see Definitions for more information.

GL3R*	Robust families
GL3C*	Consensus families
GL3M*	Multiple choice families (resolved arbitrarily in favor of smaller groups)
GL3U*	Unique element families (singletons)

Phyletic pattern
This pattern is an ordered chain of letters indicating which species are involved in the family. A letter indicates that the species is present, a dash in place of the letter shows that the species is absent.

Letter	Species
s	Saccharomyces cerevisiae
c	Candida glabrata
z	Zygosaccharomyces rouxii
l	Saccharomyces kluyveri
t	Kluyveromyces thermotolerans
k	Kluyveromyces lactis var. lactis
g	Eremothecium gossypii
d	Debaryomyces hansenii var. hansenii
y	Yarrowia lipolytica

Phylogenetic profile
This profile is an ordered chain of numbers indicating how many proteins of each species are present in the family. The order of the numbers is the same as the order in the phyletic pattern (see above).

Family relations
Click on a node of the image to go to the page of the corresponding gene. The weight of an edge between two genes is the percent amino-acid identity in a Needleman Wunch global alignment between the translation products of the two genes. The graph shown is the subgraph induces by edges with weight ≥ 20%.

Data
Colored multiple sequence alignments are computed using TCoffee.