Family		GL3R2390, 9 members
Phyletic pattern		sczltkgdy
Phylogen. profile		1 1 1 1 1 1 1 1 1
Proteins		SACE0L03674p CAGL0M11506p ZYRO0D06534p SAKL0H16368p KLTH0G13046p KLLA0F19756p ERGO0G09878p DEHA2E20130p YALI0B17644p

Family relations  

Proteins in GL3R2390  

SACE0L03674p	3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs
CAGL0M11506p	highly similar to uniprot|Q12452 Saccharomyces cerevisiae YLR100w ERG27 3-keto sterol reductase
ZYRO0D06534p	similar to uniprot|Q12452 Saccharomyces cerevisiae YLR100W ERG27 3-keto sterol reductase catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis mutants are sterol auxotrophs
SAKL0H16368p	highly similar to uniprot|Q12452 Saccharomyces cerevisiae YLR100W ERG27 3-keto sterol reductase catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis mutants are sterol auxotrophs
KLTH0G13046p	similar to uniprot|Q12452 Saccharomyces cerevisiae YLR100W ERG273-keto sterol reductase catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis mutants are sterol auxotrophs
KLLA0F19756p	highly similar to uniprot|Q12452 Saccharomyces cerevisiae YLR100W ERG27 3-keto sterol reductase catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis mutants are sterol auxotrophs
ERGO0G09878p	Syntenic homolog of Saccharomyces cerevisiae YLR100W (ERG27)
DEHA2E20130p	similar to uniprot|Q12452 Saccharomyces cerevisiae YLR100W ERG27 3-keto sterol reductase catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
YALI0B17644p	similar to uniprot|Q12452 Saccharomyces cerevisiae ORF YLR100W ERG27 3-keto sterol reductase singleton

Gene Ontology terms  

GO:0006696	ergosterol biosynthetic process
GO:0005789	endoplasmic reticulum membrane
GO:0005741	mitochondrial outer membrane
GO:0005515	protein binding
GO:0000253	3-keto sterol reductase activity

Data  

Pairwise distances

Amino-acid sequences

Multiple sequence alignment

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Legend and notes  

Type of family, see Definitions for more information.

GL3R*	Robust families
GL3C*	Consensus families
GL3M*	Multiple choice families (resolved arbitrarily in favor of smaller groups)
GL3U*	Unique element families (singletons)

Phyletic pattern
This pattern is an ordered chain of letters indicating which species are involved in the family. A letter indicates that the species is present, a dash in place of the letter shows that the species is absent.

Letter	Species
s	Saccharomyces cerevisiae
c	Candida glabrata
z	Zygosaccharomyces rouxii
l	Saccharomyces kluyveri
t	Kluyveromyces thermotolerans
k	Kluyveromyces lactis var. lactis
g	Eremothecium gossypii
d	Debaryomyces hansenii var. hansenii
y	Yarrowia lipolytica

Phylogenetic profile
This profile is an ordered chain of numbers indicating how many proteins of each species are present in the family. The order of the numbers is the same as the order in the phyletic pattern (see above).

Family relations
Click on a node of the image to go to the page of the corresponding gene. The weight of an edge between two genes is the percent amino-acid identity in a Needleman Wunch global alignment between the translation products of the two genes. The graph shown is the subgraph induces by edges with weight ≥ 20%.

Data
Colored multiple sequence alignments are computed using TCoffee.