Family		GL3R2044, 9 members
Phyletic pattern		sczltkgdy
Phylogen. profile		1 1 1 1 1 1 1 1 1
Proteins		SACE0B05148p CAGL0K07788p ZYRO0C16566p SAKL0B08030p KLTH0F10384p KLLA0B09218p ERGO0D01364p DEHA2D07964p YALI0E06457p

Family relations  

Proteins in GL3R2044  

SACE0B05148p	Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p
CAGL0K07788p	highly similar to uniprot|P07702 Saccharomyces cerevisiae YBR115c LYS2 Aminoadipate-semialdehyde dehydrogenase
ZYRO0C16566p	highly similar to uniprot|P07702 Saccharomyces cerevisiae YBR115C LYS2 Alpha aminoadipate reductase
SAKL0B08030p	highly similar to uniprot|P07702 Saccharomyces cerevisiae YBR115C LYS2 Alpha aminoadipate reductase
KLTH0F10384p	highly similar to uniprot|P07702 Saccharomyces cerevisiae YBR115C LYS2 Alpha aminoadipate reductase
KLLA0B09218p	uniprot|Q8NJ21 Kluyveromyces lactis lys2 Alpha- aminoadipate reductase
ERGO0D01364p	Syntenic homolog of Saccharomyces cerevisiae YBR115C (LYS2)
DEHA2D07964p	similar to uniprot|P07702 Saccharomyces cerevisiae YBR115C LYS2 Alpha aminoadipate reductase
YALI0E06457p	similar to uniprot|P07702 Saccharomyces cerevisiae YBR115c LYS2 L-aminoadipate-semialdehyde dehydrogenase large subunit

Gene Ontology terms  

GO:0048037	cofactor binding
GO:0019878	lysine biosynthetic process via aminoadipic acid
GO:0016874	ligase activity
GO:0008152	metabolic process
GO:0005737	cytoplasm
GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity

Data  

Pairwise distances

Amino-acid sequences

Multiple sequence alignment

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Legend and notes  

Type of family, see Definitions for more information.

GL3R*	Robust families
GL3C*	Consensus families
GL3M*	Multiple choice families (resolved arbitrarily in favor of smaller groups)
GL3U*	Unique element families (singletons)

Phyletic pattern
This pattern is an ordered chain of letters indicating which species are involved in the family. A letter indicates that the species is present, a dash in place of the letter shows that the species is absent.

Letter	Species
s	Saccharomyces cerevisiae
c	Candida glabrata
z	Zygosaccharomyces rouxii
l	Saccharomyces kluyveri
t	Kluyveromyces thermotolerans
k	Kluyveromyces lactis var. lactis
g	Eremothecium gossypii
d	Debaryomyces hansenii var. hansenii
y	Yarrowia lipolytica

Phylogenetic profile
This profile is an ordered chain of numbers indicating how many proteins of each species are present in the family. The order of the numbers is the same as the order in the phyletic pattern (see above).

Family relations
Click on a node of the image to go to the page of the corresponding gene. The weight of an edge between two genes is the percent amino-acid identity in a Needleman Wunch global alignment between the translation products of the two genes. The graph shown is the subgraph induces by edges with weight ≥ 20%.

Data
Colored multiple sequence alignments are computed using TCoffee.