Family		GL3C0289, 23 members
Phyletic pattern		sczltkgd-py
Phylogen. profile		3 3 2 2 2 2 2 2 0 4 1
Proteins		SACE0D15356p SACE0D15862p SACE0O01540p CAGL0G04609p CAGL0I07513p CAGL0K06479p ZYRO0B06512p ZYRO0C06776p SAKL0C09174p SAKL0G06402p KLTH0C09548p KLTH0G05214p KLLA0C12485p KLLA0E03587p ERGO0F13530p ERGO0F14520p DEHA2G04906p DEHA2G09592p PISO0C09528p PISO0D09595p PISO0E06780p PISO0F08123p YALI0B05566p

Family relations  

Proteins in GL3C0289  

SACE0D15356p	YDR466W PKH3, Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
SACE0D15862p	YDR490C (ohnolog of YOL100W) PKH1, Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p
SACE0O01540p	*GO_function: ATP binding; kinase activity; nucleotide binding; protein kinase activity [PMID 10567559]; protein serine/threonine kinase activity [PMID 18613951]; transferase activity;
CAGL0G04609p	(ohnolog of CAGL0I07513g), similar to uniprot|Q12236 Saccharomyces cerevisiae YOL100w PKH2; SubName: Full=Similar to uniprot|Q12236 Saccharomyces cerevisiae YOL100w PKH2;
CAGL0I07513p	(ohnolog of CAGL0G04609g), similar to uniprot|Q12236 Saccharomyces cerevisiae YOL100w PKH2; SubName: Full=Similar to uniprot|Q12236 Saccharomyces cerevisiae YOL100w PKH2;
CAGL0K06479p	some similarities with uniprot|Q03306 Saccharomyces cerevisiae YDR466w; SubName: Full=Similarities with uniprot|Q03306 Saccharomyces cerevisiae YDR466w;
ZYRO0B06512p	similar to uniprot|Q12236 YOL100W Saccharomyces cerevisiae YOL100W PKH2 Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; SubName: Full=ZYRO0B06512p;
ZYRO0C06776p	some similarities with uniprot|Q03306 Saccharomyces cerevisiae YDR466W; SubName: Full=ZYRO0C06776p;
SAKL0C09174p
SAKL0G06402p
KLTH0C09548p	similar to uniprot|Q12236 YOL100W Saccharomyces cerevisiae YOL100W PKH2 Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; SubName: Full=KLTH0C09548p;
KLTH0G05214p	weakly similar to uniprot|Q03306 Saccharomyces cerevisiae YDR466W; SubName: Full=KLTH0G05214p;
KLLA0C12485p	similar to uniprot|Q12236 YOL100W Saccharomyces cerevisiae YOL100W PKH2 Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; SubName: Full=KLLA0C12485p;
KLLA0E03587p	weakly similar to uniprot|Q03306 YDR466W Saccharomyces cerevisiae YDR466W Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant; SubName: Full=KLLA0E03587p;
ERGO0F13530p	AGOS_AFR335C, Syntenic homolog of Saccharomyces cerevisiae YOL100W (PKH2) and YDR490C (PKH1)
ERGO0F14520p	AGOS_AFR377C, Syntenic homolog of Saccharomyces cerevisiae YDR466W (PKH3)
DEHA2G04906p	similar to CA1375|IPF7158 Candida albicans; SubName: Full=DEHA2G04906p;
DEHA2G09592p	some similarities with uniprot|Q12236 Saccharomyces cerevisiae YOL100W PKH2 Serine/threonine protein kinase; SubName: Full=DEHA2G09592p;
PISO0C09528p
PISO0D09595p
PISO0E06780p
PISO0F08123p
YALI0B05566p	some similarities with uniprot|Q12236 Saccharomyces cerevisiae YOL100w PKH2 related to ser/thr protein kinases P108.1.f16.1; SubName: Full=YALI0B05566p;

Gene Ontology terms  

None available yet

Data  

Pairwise distances

Amino-acid sequences

Multiple sequence alignment

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Legend and notes  

Type of family, see Definitions for more information.

GL3R*	Robust families
GL3C*	Consensus families
GL3M*	Multiple choice families (resolved arbitrarily in favor of smaller groups)
GL3U*	Unique element families (singletons)

Phyletic pattern
This pattern is an ordered chain of letters indicating which species are involved in the family. A letter indicates that the species is present, a dash in place of the letter shows that the species is absent.

Letter	Species
s	Saccharomyces cerevisiae
c	Candida glabrata
z	Zygosaccharomyces rouxii
l	Saccharomyces kluyveri
t	Kluyveromyces thermotolerans
k	Kluyveromyces lactis var. lactis
g	Eremothecium gossypii
d	Debaryomyces hansenii var. hansenii
y	Yarrowia lipolytica

Phylogenetic profile
This profile is an ordered chain of numbers indicating how many proteins of each species are present in the family. The order of the numbers is the same as the order in the phyletic pattern (see above).

Family relations
Click on a node of the image to go to the page of the corresponding gene. The weight of an edge between two genes is the percent amino-acid identity in a Needleman Wunch global alignment between the translation products of the two genes. The graph shown is the subgraph induces by edges with weight ≥ 20%.

Data
Colored multiple sequence alignments are computed using TCoffee.