Family		GL3C0218, 21 members
Phyletic pattern		sczltkgdy
Phylogen. profile		3 3 3 2 2 2 2 2 2
Proteins		SACE0G04026p SACE0P01254p SACE0P02046p CAGL0E06050p CAGL0G09251p CAGL0H03289p ZYRO0E07700p ZYRO0G08382p ZYRO0G15488p SAKL0A03520p SAKL0A04972p KLTH0H03234p KLTH0H04642p KLLA0C16049p KLLA0E19273p ERGO0F02398p ERGO0F03784p DEHA2D02530p DEHA2E22726p YALI0E13970p YALI0F07865p

Family relations  

Proteins in GL3C0218  

SACE0G04026p	Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene
SACE0P01254p	Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
SACE0P02046p	Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
CAGL0E06050p	similar to uniprot|O13297 Saccharomyces cerevisiae YPL228w CET1
CAGL0G09251p	similar to uniprot|Q08930 Saccharomyces cerevisiae YPL191c or uniprot|P53155 Saccharomyces cerevisiae YGL082w
CAGL0H03289p	similar to uniprot|P53155 Saccharomyces cerevisiae YGL082w
ZYRO0E07700p	highly similar to uniprot|O13297 Saccharomyces cerevisiae YPL228W CET1 Interacts with Ceg1p the mRNA capping enzyme alpha subunit removes gamma-phosphate from triphosphate-terminated RNA mRNA capping enzyme beta subunit RNA 5'-triphosphatase
ZYRO0G08382p	similar to uniprot|P53155 Saccharomyces cerevisiae YGL082W and similar to uniprot|Q08930 Saccharomyces cerevisiae YPL191C Hypothetical ORFs
ZYRO0G15488p	some similarities with uniprot|O13297 Saccharomyces cerevisiae YPL228W CET1 Interacts with Ceg1p the mRNA capping enzyme alpha subunit removes gamma-phosphate from triphosphate-terminated RNA mRNA capping enzyme beta subunit (80 kDa) RNA 5'-triphosphatase
SAKL0A03520p	similar to uniprot|O13297 Saccharomyces cerevisiae YPL228W CET1 Interacts with Ceg1p the mRNA capping enzyme alpha subunit removes gamma-phosphate from triphosphate- terminated RNA mRNA capping enzyme beta subunit RNA 5'- triphosphatase
SAKL0A04972p	similar to uniprot|P53155 Saccharomyces cerevisiae YGL082W and similar to uniprot|Q08930 Saccharomyces cerevisiae YPL191C Hypothetical ORFs
KLTH0H03234p	highly similar to uniprot|O13297 Saccharomyces cerevisiae YPL228W CET1 Interacts with Ceg1p the mRNA capping enzyme alpha subunit removes gamma-phosphate from triphosphate-terminated RNA mRNA capping enzyme beta subunit RNA 5'-triphosphatase
KLTH0H04642p	similar to uniprot|P53155 Saccharomyces cerevisiae YGL082W and similar to uniprot|Q08930 Saccharomyces cerevisiae YPL191C Hypothetical ORFs
KLLA0C16049p	similar to uniprot|O13297 Saccharomyces cerevisiae YPL228W CET1 Interacts with Ceg1p the mRNA capping enzyme alpha subunit removes gamma-phosphate from triphosphate- terminated RNA mRNA capping enzyme beta subunit RNA 5'- triphosphatase
KLLA0E19273p	similar to uniprot|P53155 Saccharomyces cerevisiae YGL082W and similar to uniprot|Q08930 Saccharomyces cerevisiae YPL191C Hypothetical ORFs
ERGO0F02398p	Syntenic homolog of Saccharomyces cerevisiae YPL228W (CET1) and YMR180C (CTL1)
ERGO0F03784p	Syntenic homolog of Saccharomyces cerevisiae YGL082W and YPL191C
DEHA2D02530p	weakly similar to uniprot|Q08930 Saccharomyces cerevisiae YPL191c or uniprot|P53155 Saccharomyces cerevisiae YGL082w
DEHA2E22726p	similar to uniprot|O13297 Saccharomyces cerevisiae YPL228W CET1 Interacts with Ceg1p the mRNA capping enzyme alpha subunit
YALI0E13970p	some similarities with DEHA0D03223g Debaryomyces hansenii
YALI0F07865p	some similarities with uniprot|O13297 Saccharomyces cerevisiae YPL228w CET1 RNA 5'-triphosphatase (mRNA capping enzyme beta subunit)

Gene Ontology terms  

GO:0042802	identical protein binding
GO:0031533	mRNA capping enzyme complex
GO:0006370	mRNA capping
GO:0005737	cytoplasm
GO:0005634	nucleus
GO:0004651	polynucleotide 5'-phosphatase activity

Data  

Pairwise distances

Amino-acid sequences

Multiple sequence alignment

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Legend and notes  

Type of family, see Definitions for more information.

GL3R*	Robust families
GL3C*	Consensus families
GL3M*	Multiple choice families (resolved arbitrarily in favor of smaller groups)
GL3U*	Unique element families (singletons)

Phyletic pattern
This pattern is an ordered chain of letters indicating which species are involved in the family. A letter indicates that the species is present, a dash in place of the letter shows that the species is absent.

Letter	Species
s	Saccharomyces cerevisiae
c	Candida glabrata
z	Zygosaccharomyces rouxii
l	Saccharomyces kluyveri
t	Kluyveromyces thermotolerans
k	Kluyveromyces lactis var. lactis
g	Eremothecium gossypii
d	Debaryomyces hansenii var. hansenii
y	Yarrowia lipolytica

Phylogenetic profile
This profile is an ordered chain of numbers indicating how many proteins of each species are present in the family. The order of the numbers is the same as the order in the phyletic pattern (see above).

Family relations
Click on a node of the image to go to the page of the corresponding gene. The weight of an edge between two genes is the percent amino-acid identity in a Needleman Wunch global alignment between the translation products of the two genes. The graph shown is the subgraph induces by edges with weight ≥ 20%.

Data
Colored multiple sequence alignments are computed using TCoffee.