Family		GL3C0213, 21 members
Phyletic pattern		sczltkgdy
Phylogen. profile		2 3 2 2 2 2 2 3 3
Proteins		SACE0D04136p SACE0D09856p CAGL0C01221p CAGL0D01034p CAGL0H04983p ZYRO0A09284p ZYRO0B07150p SAKL0H03454p SAKL0H13090p KLTH0D13948p KLTH0F07942p KLLA0A04235p KLLA0E05435p ERGO0F19822p ERGO0G06292p DEHA2E15862p DEHA2F01056p DEHA2G14322p YALI0B15708p YALI0C06490p YALI0E15125p

Family relations  

Proteins in GL3C0213  

SACE0D04136p	GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
SACE0D09856p	Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
CAGL0C01221p	highly similar to uniprot|P32501 Saccharomyces cerevisiae YDR211w GCD6
CAGL0D01034p	highly similar to uniprot|P41940 Saccharomyces cerevisiae YDL055c PSA1 mannose-1-phosphate guanyltransferase
CAGL0H04983p	highly similar to uniprot|P41940 Saccharomyces cerevisiae YDL055c PSA1 mannose-1-phosphate guanyltransferase
ZYRO0A09284p	similar to uniprot|P32501 Saccharomyces cerevisiae YDR211W GCD6 Catalytic epsilon subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression
ZYRO0B07150p	highly similar to uniprot|P41940 Saccharomyces cerevisiae YDL055C PSA1 GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase) synthesizes GDP- mannose from GTP and mannose-1-phosphate in cell wall biosynthesis required for normal cell wall structure
SAKL0H03454p	highly similar to uniprot|P41940 Saccharomyces cerevisiae YDL055C PSA1 GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase) synthesizes GDP- mannose from GTP and mannose-1-phosphate in cell wall biosynthesis required for normal cell wall structure
SAKL0H13090p	similar to uniprot|P32501 Saccharomyces cerevisiae YDR211W GCD6 Catalytic epsilon subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression
KLTH0D13948p	highly similar to uniprot|P41940 Saccharomyces cerevisiae YDL055C PSA1 GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase) synthesizes GDP- mannose from GTP and mannose-1-phosphate in cell wall biosynthesis required for normal cell wall structure
KLTH0F07942p	similar to uniprot|P32501 Saccharomyces cerevisiae YDR211W GCD6 Catalytic epsilon subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression
KLLA0A04235p	similar to uniprot|P32501 Saccharomyces cerevisiae YDR211W GCD6 Catalytic epsilon subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression
KLLA0E05435p	highly similar to uniprot|P41940 Saccharomyces cerevisiae YDL055C PSA1 GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase) synthesizes GDP- mannose from GTP and mannose-1-phosphate in cell wall biosynthesis required for normal cell wall structure
ERGO0F19822p	Syntenic homolog of Saccharomyces cerevisiae YDL055C (PSA1)
ERGO0G06292p	Syntenic homolog of Saccharomyces cerevisiae YDR211W (GCD6)
DEHA2E15862p	weakly similar to uniprot|P41940 Saccharomyces cerevisiae YDL055C PSA1 GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase) synthesizes GDP- mannose from GTP and mannose-1-phosphate in cell wall biosynthesis
DEHA2F01056p	highly similar to uniprot|P41940 Saccharomyces cerevisiae YDL055C PSA1 GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase) synthesizes GDP- mannose from GTP and mannose-1-phosphate in cell wall biosynthesis
DEHA2G14322p	similar to uniprot|P32501 Saccharomyces cerevisiae YDR211W GCD6 Catalytic epsilon subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2
YALI0B15708p	similar to uniprot|P32501 Saccharomyces cerevisiae YDR211w GCD6 translation initiation factor eIF2b epsilon 81 kDa subunit
YALI0C06490p	highly similar to uniprot|O93827 Candida albicans CaPSA1 Mannose-1-phosphate guanyltransferase (EC 2.7.7.13)
YALI0E15125p	similar to uniprot|O60064 Schizosaccharomyces pombe Putative mannose-1-phosphate guanyltransferase

Gene Ontology terms  

GO:0032045	guanyl-nucleotide exchange factor complex
GO:0016779	nucleotidyltransferase activity
GO:0009298	GDP-mannose biosynthetic process
GO:0009058	biosynthetic process
GO:0008415	acyltransferase activity
GO:0006486	protein amino acid glycosylation
GO:0006446	regulation of translational initiation
GO:0005851	eukaryotic translation initiation factor 2B complex
GO:0005737	cytoplasm
GO:0005515	protein binding
GO:0005488	binding
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0004475	mannose-1-phosphate guanylyltransferase activity
GO:0003743	translation initiation factor activity
GO:0000032	cell wall mannoprotein biosynthetic process

Data  

Pairwise distances

Amino-acid sequences

Multiple sequence alignment

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Legend and notes  

Type of family, see Definitions for more information.

GL3R*	Robust families
GL3C*	Consensus families
GL3M*	Multiple choice families (resolved arbitrarily in favor of smaller groups)
GL3U*	Unique element families (singletons)

Phyletic pattern
This pattern is an ordered chain of letters indicating which species are involved in the family. A letter indicates that the species is present, a dash in place of the letter shows that the species is absent.

Letter	Species
s	Saccharomyces cerevisiae
c	Candida glabrata
z	Zygosaccharomyces rouxii
l	Saccharomyces kluyveri
t	Kluyveromyces thermotolerans
k	Kluyveromyces lactis var. lactis
g	Eremothecium gossypii
d	Debaryomyces hansenii var. hansenii
y	Yarrowia lipolytica

Phylogenetic profile
This profile is an ordered chain of numbers indicating how many proteins of each species are present in the family. The order of the numbers is the same as the order in the phyletic pattern (see above).

Family relations
Click on a node of the image to go to the page of the corresponding gene. The weight of an edge between two genes is the percent amino-acid identity in a Needleman Wunch global alignment between the translation products of the two genes. The graph shown is the subgraph induces by edges with weight ≥ 20%.

Data
Colored multiple sequence alignments are computed using TCoffee.