Family		GL3C0121, 33 members
Phyletic pattern		sczltkgd-py
Phylogen. profile		3 3 3 3 3 3 3 3 0 6 3
Proteins		SACE0E01254p SACE0H01958p SACE0P01122p CAGL0E06204p CAGL0I01562p CAGL0J00627p ZYRO0E02970p ZYRO0E07832p ZYRO0G16016p SAKL0A03388p SAKL0D11418p SAKL0G11044p KLTH0G07062p KLTH0H03124p KLTH0H14498p KLLA0C15917p KLLA0E11529p KLLA0E22441p ERGO0C06380p ERGO0E06578p ERGO0F02222p DEHA2D10032p DEHA2E16368p DEHA2F11638p PISO0K04894p PISO0K10526p PISO0L04895p PISO0L10527p PISO0M20758p PISO0N21001p YALI0E31471p YALI0F09405p YALI0F24475p

Family relations  

Proteins in GL3C0121  

SACE0E01254p	YEL027W CUP5, Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
SACE0H01958p	YHR026W PPA1, Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain
SACE0P01122p	*GO_function: hydrogen ion transmembrane transporter activity; proton-transporting ATPase activity, rotational mechanism [PMID 9442887] [PMID 10224039];
CAGL0E06204p	highly similar to uniprot|P32842 Saccharomyces cerevisiae YPL234c TFP3; RecName: Full=V-type proton ATPase 16 kDa proteolipid subunit 2; Short=V-ATPase 16 kDa proteolipid subunit 2; AltName: Full=Proteolipid protein VMA11; AltName: Full=Vacuolar proton pump 16 kDa proteolipid subunit 2;
CAGL0I01562p	highly similar to uniprot|P25515 Saccharomyces cerevisiae YEL027w CUP5; SubName: Full=Similar to uniprot|P25515 Saccharomyces cerevisiae YEL027w CUP5;
CAGL0J00627p	highly similar to uniprot|P23968 Saccharomyces cerevisiae YHR026w PPA1; SubName: Full=Similar to uniprot|P23968 Saccharomyces cerevisiae YHR026w PPA1;
ZYRO0E02970p	similar to uniprot|P25515 Saccharomyces cerevisiae YEL027W CUP5 Proteolipid subunit of the vacuolar H( )- ATPase V0 sector required for vacuolar acidification and important for copper and iron metal ion homeostasis; SubName: Full=ZYRO0E02970p;
ZYRO0E07832p	similar to uniprot|P32842 Saccharomyces cerevisiae YPL234C TFP3 vacuolar ATPase V0 domain subunit c'; SubName: Full=ZYRO0E07832p;
ZYRO0G16016p	similar to uniprot|P23968 Saccharomyces cerevisiae YHR026W PPA1 Subunit c'' of the vacuolar ATPase which functions in acidification of the vacuole; SubName: Full=ZYRO0G16016p;
SAKL0A03388p	highly similar to uniprot|P32842 Saccharomyces cerevisiae YPL234C TFP3 Vacuolar ATPase V0 domain subunit c', involved in proton transport activity;
SAKL0D11418p
SAKL0G11044p	similar to uniprot|P23968 Saccharomyces cerevisiae YHR026W PPA1 Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole;
KLTH0G07062p	similar to uniprot|P23968 Saccharomyces cerevisiae YHR026W PPA1 Subunit c'' of the vacuolar ATPase which functions in acidification of the vacuole; SubName: Full=KLTH0G07062p;
KLTH0H03124p	highly similar to uniprot|P32842 Saccharomyces cerevisiae YPL234C TFP3 vacuolar ATPase V0 domain subunit c'; SubName: Full=KLTH0H03124p;
KLTH0H14498p	similar to uniprot|P25515 Saccharomyces cerevisiae YEL027W CUP5 Proteolipid subunit of the vacuolar H( )- ATPase V0 sector required for vacuolar acidification and important for copper and iron metal ion homeostasis; SubName: Full=KLTH0H14498p;
KLLA0C15917p	highly similar to uniprot|P32842 Saccharomyces cerevisiae YPL234C TFP3 vacuolar ATPase V0 domain subunit c'; RecName: Full=V-type proton ATPase 16 kDa proteolipid subunit 2; Short=V-ATPase 16 kDa proteolipid subunit 2; AltName: Full=Proteolipid protein VMA11; AltName: Full=Vacuolar proton pump 16 kDa proteolipid subunit 2;
KLLA0E11529p	similar to uniprot|P23968 Saccharomyces cerevisiae YHR026W PPA1 Subunit c'' of the vacuolar ATPase which functions in acidification of the vacuole; SubName: Full=KLLA0E11529p;
KLLA0E22441p	similar to uniprot|P25515 Saccharomyces cerevisiae YEL027W CUP5 Proteolipid subunit of the vacuolar H( )- ATPase V0 sector required for vacuolar acidification and important for copper and iron metal ion homeostasis; SubName: Full=KLLA0E22441p;
ERGO0C06380p	AGOS_ACR071W, Syntenic homolog of Saccharomyces cerevisiae YHR026W (PPA1)
ERGO0E06578p	AGOS_AEL074W, Syntenic homolog of Saccharomyces cerevisiae YEL027W (CUP5)
ERGO0F02222p	AGOS_AFL141C, Syntenic homolog of Saccharomyces cerevisiae YPL234C (TFP3)
DEHA2D10032p	highly similar to uniprot|P32842 Saccharomyces cerevisiae YPL234C TFP3 vacuolar H+-ATPase V0 domain 17 KD subunit; RecName: Full=V-type proton ATPase 16 kDa proteolipid subunit 2; Short=V-ATPase 16 kDa proteolipid subunit 2; AltName: Full=Proteolipid protein VMA11; AltName: Full=Vacuolar proton pump 16 kDa proteolipid subunit 2;
DEHA2E16368p	highly similar to uniprot|P23968 Saccharomyces cerevisiae YHR026W PPA1 Subunit C of the vacuolar ATPase; SubName: Full=DEHA2E16368p;
DEHA2F11638p	highly similar to uniprot|P25515 Saccharomyces cerevisiae YEL027W CUP5 Proteolipid subunit of the vacuolar H( )-ATPase V0 sector (subunit c dicyclohexylcarbodiimide binding subunit) required for vacuolar acidification and important for copper and iron metal ion homeostasis; SubName: Full=DEHA2F11638p;
PISO0K04894p	highly similar to uniprot|P32842 Saccharomyces cerevisiae SACE0P01122g VATL2_YEAST CLS9 TFP3 VMA11 YPL234C Vacuolar ATPase V0 domain subunit c' involved in proton transport activity;
PISO0K10526p
PISO0L04895p	highly similar to uniprot|P32842 Saccharomyces cerevisiae SACE0P01122g VATL2_YEAST CLS9 TFP3 VMA11 YPL234C Vacuolar ATPase V0 domain subunit c' involved in proton transport activity;
PISO0L10527p
PISO0M20758p	similar to uniprot|P23968 Saccharomyces cerevisiae SACE0H01958g VATO_YEAST PPA1 VMA16 YHR026W Subunit c'' of the vacuolar ATPase which functions in acidification of the vacuole;
PISO0N21001p	similar to uniprot|P23968 Saccharomyces cerevisiae SACE0H01958g VATO_YEAST PPA1 VMA16 YHR026W Subunit c'' of the vacuolar ATPase which functions in acidification of the vacuole;
YALI0E31471p	highly similar to uniprot|P32842 Saccharomyces cerevisiae YPL234c TFP3 H+-ATPase V0 domain 17 KD subunit vacuolar; SubName: Full=YALI0E31471p;
YALI0F09405p	highly similar to uniprot|P23968 Saccharomyces cerevisiae YHR026w PPA1 H+-ATPase; SubName: Full=YALI0F09405p;
YALI0F24475p	highly similar to uniprot|Q00607 Candida tropicalis Vacuolar ATP synthase 16 kDa proteolipid subunit (EC 3.6.3. 14) and uniprot|P25515 Saccharomyces cerevisiae YEL027w CUP5 H+-ATPase V0 domain 17 KD subunit vacuolar and wi|NCU01332.1 Neurospora crassa NCU01332.1 VACUOLAR ATP SYNTHASE; SubName: Full=YALI0F24475p;

Gene Ontology terms  

None available yet

Data  

Pairwise distances

Amino-acid sequences

Multiple sequence alignment

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Legend and notes  

Type of family, see Definitions for more information.

GL3R*	Robust families
GL3C*	Consensus families
GL3M*	Multiple choice families (resolved arbitrarily in favor of smaller groups)
GL3U*	Unique element families (singletons)

Phyletic pattern
This pattern is an ordered chain of letters indicating which species are involved in the family. A letter indicates that the species is present, a dash in place of the letter shows that the species is absent.

Letter	Species
s	Saccharomyces cerevisiae
c	Candida glabrata
z	Zygosaccharomyces rouxii
l	Saccharomyces kluyveri
t	Kluyveromyces thermotolerans
k	Kluyveromyces lactis var. lactis
g	Eremothecium gossypii
d	Debaryomyces hansenii var. hansenii
y	Yarrowia lipolytica

Phylogenetic profile
This profile is an ordered chain of numbers indicating how many proteins of each species are present in the family. The order of the numbers is the same as the order in the phyletic pattern (see above).

Family relations
Click on a node of the image to go to the page of the corresponding gene. The weight of an edge between two genes is the percent amino-acid identity in a Needleman Wunch global alignment between the translation products of the two genes. The graph shown is the subgraph induces by edges with weight ≥ 20%.

Data
Colored multiple sequence alignments are computed using TCoffee.