GL3C0069

Family relations  



Proteins in GL3C0069  


SACE0C01144p*GO_function: 3-isopropylmalate dehydrogenase activity [PMID 3071718] [PMID 6297759]; magnesium ion binding; metal ion binding; NAD or NADH binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;
SACE0I01870p*GO_function: homoisocitrate dehydrogenase activity [PMID 17223711]; magnesium ion binding; metal ion binding; NAD or NADH binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;
SACE0N06446p
SACE0O06864p
CAGL0G02585phighly similar to uniprot|P40495 Saccharomyces cerevisiae YIL094c LYS12 homo-isocitrate dehydrogenase; SubName: Full=Strain CBS138 chromosome G complete sequence;
CAGL0G02673phighly similar to uniprot|P28834 Saccharomyces cerevisiae YNL037c IDH1 or uniprot|P28241 Saccharomyces cerevisiae YOR136w IDH2; SubName: Full=Strain CBS138 chromosome G complete sequence;
CAGL0H03795p
CAGL0I07227phighly similar to uniprot|P28241 Saccharomyces cerevisiae YOR136w IDH2 isocitrate dehydrogenase; SubName: Full=Strain CBS138 chromosome I complete sequence;
ZYRO0A01914phighly similar to uniprot|P40495 Saccharomyces cerevisiae YIL094C LYS12 Homo-isocitrate dehydrogenase an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine in which homo- isocitrate is oxidatively decarboxylated to alpha- ketoadipate; SubName: Full=ZYRO0A01914p;
ZYRO0D02838psimilar to uniprot|P28834 Saccharomyces cerevisiae YNL037C IDH1 Subunit of mitochondrial NAD( )-dependent isocitrate dehydrogenase which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; SubName: Full=ZYRO0D02838p;
ZYRO0D11220phighly similar to uniprot|P28241 Saccharomyces cerevisiae YOR136W IDH2 Subunit of mitochondrial NAD( )- dependent isocitrate dehydrogenase which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; SubName: Full=ZYRO0D11220p;
ZYRO0E04796puniprot|Q96WI0 Zygosaccharomyces rouxii LEU2 3- isopropylmalate dehydrogenase; RecName: Full=3-isopropylmalate dehydrogenase; Short=3-IPM-DH; Short=IMDH; EC=1.1.1.85; AltName: Full=Beta-IPM dehydrogenase;
SAKL0D08690p
SAKL0E07656phighly similar to uniprot|P40495 Saccharomyces cerevisiae YIL094C LYS12 Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo- isocitrate is oxidatively decarboxylated to alpha- ketoadipate;
SAKL0E07876phighly similar to uniprot|P28834 Saccharomyces cerevisiae YNL037C IDH1 Subunit of mitochondrial NAD(+)- dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle;
SAKL0G03520phighly similar to uniprot|P28241 Saccharomyces cerevisiae YOR136W IDH2 Subunit of mitochondrial NAD(+)- dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle;
KLTH0F15048phighly similar to uniprot|P28241 Saccharomyces cerevisiae YOR136W IDH2 Subunit of mitochondrial NAD( )- dependent isocitrate dehydrogenase which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; SubName: Full=KLTH0F15048p;
KLTH0G10186phighly similar to uniprot|P28834 Saccharomyces cerevisiae YNL037C IDH1 Subunit of mitochondrial NAD( )- dependent isocitrate dehydrogenase which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; SubName: Full=KLTH0G10186p;
KLTH0G10384phighly similar to uniprot|P40495 Saccharomyces cerevisiae YIL094C LYS12 Homo-isocitrate dehydrogenase an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine in which homo- isocitrate is oxidatively decarboxylated to alpha- ketoadipate; SubName: Full=KLTH0G10384p;
KLTH0H12188phighly similar to uniprot|P04173 Saccharomyces cerevisiae YCL018W LEU2 Beta-isopropylmalate dehydrogenase catalyzes the third step in the leucine biosynthesis pathway; RecName: Full=3-isopropylmalate dehydrogenase; EC=1.1.1.85;
KLLA0D04906phighly similar to uniprot|P04173 Saccharomyces cerevisiae YCL018W LEU2 Beta-isopropylmalate dehydrogenase catalyzes the third step in the leucine biosynthesis pathway; RecName: Full=3-isopropylmalate dehydrogenase; Short=3-IPM-DH; Short=IMDH; EC=1.1.1.85; AltName: Full=Beta-IPM dehydrogenase;
KLLA0E03125phighly similar to uniprot|P28241 Saccharomyces cerevisiae YOR136W IDH2 Subunit of mitochondrial NAD( )- dependent isocitrate dehydrogenase which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle;
KLLA0E08339phighly similar to uniprot|P40495 Saccharomyces cerevisiae YIL094C LYS12 Homo-isocitrate dehydrogenase an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine in which homo- isocitrate is oxidatively decarboxylated to alpha- ketoadipate; SubName: Full=KLLA0E08339p;
KLLA0F04103puniprot|O94229 Kluyveromyces lactis KLLA0F04103g IDH1 Isocitrate dehydrogenase subunit 1; RecName: Full=Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial; EC=1.1.1.41; AltName: Full=Isocitric dehydrogenase; AltName: Full=NAD(+)-specific ICDH; Flags: Precursor;
ERGO0A04114pAGOS_AAL012C, Syntenic homolog of Saccharomyces cerevisiae YCL018W (LEU2)
ERGO0D04114pAGOS_ADL223W, Syntenic homolog of Saccharomyces cerevisiae YNL037C (IDH1)
ERGO0D04334pAGOS_ADL214C, Syntenic homolog of Saccharomyces cerevisiae YIL094C (LYS12)
ERGO0F08822pAGOS_AFR137C, Syntenic homolog of Saccharomyces cerevisiae YOR136W (IDH2)
DEHA2C10758phighly similar to uniprot|P28834 Saccharomyces cerevisiae YNL037C IDH1 Subunit of mitochondrial NAD( )- dependent isocitrate dehydrogenase; SubName: Full=DEHA2C10758p;
DEHA2C16852psimilar to uniprot|P40495 Saccharomyces cerevisiae YIL094c LYS12 homo-isocitrate dehydrogenase; SubName: Full=DEHA2C16852p;
DEHA2G05786psimilar to uniprot|P28241 Saccharomyces cerevisiae YOR136W IDH2 Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; SubName: Full=DEHA2G05786p;
DEHA2G10978psimilar to uniprot|P04173 Saccharomyces cerevisiae YCL018W LEU2 Beta-isopropylmalate dehydrogenase; RecName: Full=3-isopropylmalate dehydrogenase; Short=3-IPM-DH; Short=IMDH; EC=1.1.1.85; AltName: Full=Beta-IPM dehydrogenase;
PISO0C08670psimilar to uniprot|P28241 Saccharomyces cerevisiae SACE0O06864g IDH2_YEAST IDH2 YOR136W Subunit of mitochondrial NAD()-dependent isocitrate dehydrogenase which catalyzes the oxidation of isocitrate to alpha- ketoglutarate in the TCA cycle;
PISO0D08737psimilar to uniprot|P28241 Saccharomyces cerevisiae SACE0O06864g IDH2_YEAST IDH2 YOR136W Subunit of mitochondrial NAD()-dependent isocitrate dehydrogenase which catalyzes the oxidation of isocitrate to alpha- ketoglutarate in the TCA cycle;
PISO0E08122p
PISO0F09465p
PISO0G11798psimilar to uniprot|P28834 Saccharomyces cerevisiae SACE0N06446g IDH1_YEAST IDH1 YNL037C Subunit of mitochondrial NAD()-dependent isocitrate dehydrogenase which catalyzes the oxidation of isocitrate to alpha- ketoglutarate in the TCA cycle;
PISO0H11799psimilar to uniprot|P28834 Saccharomyces cerevisiae SACE0N06446g IDH1_YEAST IDH1 YNL037C Subunit of mitochondrial NAD()-dependent isocitrate dehydrogenase which catalyzes the oxidation of isocitrate to alpha- ketoglutarate in the TCA cycle;
PISO0K22252psimilar to uniprot|P40495 Saccharomyces cerevisiae SACE0I01870g LYS12_YEAST LYS10 LYS11 LYS12 YIL094C Homo- isocitrate dehydrogenase an NAD- linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate;
PISO0L22253psimilar to uniprot|P40495 Saccharomyces cerevisiae SACE0I01870g LYS12_YEAST LYS10 LYS11 LYS12 YIL094C Homo- isocitrate dehydrogenase an NAD- linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate;
YALI0C00407puniprot|P18120 Yarrowia lipolytica beta-isopropyl- malate dehydrogenase; RecName: Full=3-isopropylmalate dehydrogenase; Short=3-IPM-DH; Short=IMDH; EC=1.1.1.85; AltName: Full=Beta-IPM dehydrogenase;
YALI0D06303phighly similar to uniprot|P28241 Saccharomyces cerevisiae YOR136w IDH2 isocitrate dehydrogenase; SubName: Full=YALI0D06303p;
YALI0D10593psimilar to uniprot|P40495 Saccharomyces cerevisiae YIL094c LYS12 homo-isocitrate dehydrogenase; SubName: Full=YALI0D10593p;
YALI0E05137psimilar to uniprot|P28834 Saccharomyces cerevisiae YNL037c IDH1 isocitrate dehydrogenase (NAD+) subunit 1 mitochondrial; SubName: Full=YALI0E05137p;

Gene Ontology terms  


None available yet



Legend and notes  


Type of family, see Definitions for more information.
GL3R*     Robust families
GL3C*     Consensus families
GL3M*     Multiple choice families (resolved arbitrarily in favor of smaller groups)
GL3U*     Unique element families (singletons)

Phyletic pattern
This pattern is an ordered chain of letters indicating which species are involved in the family. A letter indicates that the species is present, a dash in place of the letter shows that the species is absent.
LetterSpecies
sSaccharomyces cerevisiae
cCandida glabrata
zZygosaccharomyces rouxii
lSaccharomyces kluyveri
tKluyveromyces thermotolerans
kKluyveromyces lactis var. lactis
gEremothecium gossypii
dDebaryomyces hansenii var. hansenii
yYarrowia lipolytica

Phylogenetic profile
This profile is an ordered chain of numbers indicating how many proteins of each species are present in the family. The order of the numbers is the same as the order in the phyletic pattern (see above).

Family relations
Click on a node of the image to go to the page of the corresponding gene. The weight of an edge between two genes is the percent amino-acid identity in a Needleman Wunch global alignment between the translation products of the two genes. The graph shown is the subgraph induces by edges with weight ≥ 20%.

Data
Colored multiple sequence alignments are computed using TCoffee.