Family		GL3C0060, 46 members
Phyletic pattern		sczltkgd-py
Phylogen. profile		4 4 4 4 4 4 4 4 0 8 6
Proteins		SACE0K00440p SACE0L11945p SACE0M10274p SACE0P00352p CAGL0A01133p CAGL0E00385p CAGL0K00363p CAGL0M13739p ZYRO0D07106p ZYRO0F00396p ZYRO0F17050p ZYRO0G02244p SAKL0A10208p SAKL0C02244p SAKL0E00748p SAKL0H00968p KLTH0B01100p KLTH0B09482p KLTH0C11616p KLTH0F02024p KLLA0A10131p KLLA0B14256p KLLA0C01991p KLLA0D00748p ERGO0C05280p ERGO0F15840p ERGO0F21802p ERGO0G00880p DEHA2B03894p DEHA2B07172p DEHA2E23760p DEHA2F17226p PISO0A08030p PISO0B08097p PISO0I06388p PISO0J08193p PISO0M08064p PISO0M12134p PISO0N08219p PISO0N12443p YALI0A11473p YALI0B12188p YALI0E00880p YALI0E05973p YALI0E08030p YALI0F20174p

Family relations  

Proteins in GL3C0060  

SACE0K00440p	YKL209C STE6, Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells
SACE0L11945p	*GO_function: ATP binding; ATPase activity [PMID 12746444]; ATPase activity, coupled to transmembrane movement of substances; nucleoside-triphosphatase activity; nucleotide binding; oligopeptide-transporting ATPase activity [PMID 11251115];
SACE0M10274p	*GO_function: ATP binding; ATPase activity [PMID 16754360]; ATPase activity, coupled to transmembrane movement of substances [PMID 7828591]; nucleoside- triphosphatase activity; nucleotide binding;
SACE0P00352p	YPL270W MDL2, Mitochondrial inner membrane half- type ATP- binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis;Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis
CAGL0A01133p	similar to uniprot|P33311 Saccharomyces cerevisiae YPL270w MDL2; SubName: Full=Similar to uniprot|P33311 Saccharomyces cerevisiae YPL270w MDL2;
CAGL0E00385p	similar to uniprot|P33310 Saccharomyces cerevisiae YLR188w MDL1 or uniprot|P33311 Saccharomyces cerevisiae YPL270w MDL2; SubName: Full=Strain CBS138 chromosome E complete sequence;
CAGL0K00363p	similar to uniprot|P12866 Saccharomyces cerevisiae YKL209c STE6; SubName: Full=Similar to uniprot|P12866 Saccharomyces cerevisiae YKL209c STE6;
CAGL0M13739p	similar to uniprot|P40416 Saccharomyces cerevisiae YMR301c ATM1; RecName: Full=Iron-sulfur clusters transporter ATM1, mitochondrial; Flags: Precursor;
ZYRO0D07106p	similar to uniprot|P40416 Saccharomyces cerevisiae YMR301C ATM1 Mitochondrial inner membrane transporter exports mitochondrially synthesized precursors of iron- sulfur (Fe/S) clusters to the cytosol member of the ATP- binding cassette (ABC) transporter family; SubName: Full=ZYRO0D07106p;
ZYRO0F00396p	similar to uniprot|P33311 Saccharomyces cerevisiae YPL270W MDL2 Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane; SubName: Full=ZYRO0F00396p;
ZYRO0F17050p	similar to uniprot|P33310 Saccharomyces cerevisiae YLR188W MDL1 Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane mediates export of peptides generated upon proteolysis of mitochondrial proteins plays a role in the regulation of cellular resistance to oxidative stress; SubName: Full=ZYRO0F17050p;
ZYRO0G02244p	similar to uniprot|P12866 Saccharomyces cerevisiae YKL209C STE6 ATP-binding cassette (ABC) transporter required for the export of a-factor catalyzes ATP hydrolysis coupled to a-factor transport contains 12 transmembrane domains and two ATP binding domains expressed only in MATa cells; SubName: Full=ZYRO0G02244p;
SAKL0A10208p
SAKL0C02244p
SAKL0E00748p
SAKL0H00968p
KLTH0B01100p	similar to uniprot|P12866 Saccharomyces cerevisiae YKL209C STE6 ATP-binding cassette (ABC) transporter required for the export of a-factor catalyzes ATP hydrolysis coupled to a-factor transport contains 12 transmembrane domains and two ATP binding domains expressed only in MATa cells; SubName: Full=KLTH0B01100p;
KLTH0B09482p	similar to uniprot|P40416 Saccharomyces cerevisiae YMR301C ATM1 Mitochondrial inner membrane transporter exports mitochondrially synthesized precursors of iron- sulfur (Fe/S) clusters to the cytosol member of the ATP- binding cassette (ABC) transporter family; SubName: Full=KLTH0B09482p;
KLTH0C11616p	similar to uniprot|P33311 Saccharomyces cerevisiae YPL270W MDL2 Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane; SubName: Full=KLTH0C11616p;
KLTH0F02024p	similar to uniprot|P33310 Saccharomyces cerevisiae YLR188W MDL1 Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane mediates export of peptides generated upon proteolysis of mitochondrial proteins plays a role in the regulation of cellular resistance to oxidative stress; SubName: Full=KLTH0F02024p;
KLLA0A10131p	similar to uniprot|P40416 Saccharomyces cerevisiae YMR301C ATM1 Mitochondrial inner membrane transporter exports mitochondrially synthesized precursors of iron- sulfur (Fe/S) clusters to the cytosol member of the ATP- binding cassette (ABC) transporter family; RecName: Full=Iron-sulfur clusters transporter ATM1, mitochondrial; Flags: Precursor;
KLLA0B14256p	similar to uniprot|P12866 Saccharomyces cerevisiae YKL209C STE6 ATP-binding cassette (ABC) transporter required for the export of a-factor catalyzes ATP hydrolysis coupled to a-factor transport contains 12 transmembrane domains and two ATP binding domains expressed only in MATa cells; SubName: Full=KLLA0B14256p;
KLLA0C01991p	similar to uniprot|P33310 Saccharomyces cerevisiae YLR188W MDL1 Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane mediates export of peptides generated upon proteolysis of mitochondrial proteins plays a role in the regulation of cellular resistance to oxidative stress; SubName: Full=KLLA0C01991p;
KLLA0D00748p	similar to uniprot|P33311 Saccharomyces cerevisiae YPL270W MDL2 Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane; SubName: Full=KLLA0D00748p;
ERGO0C05280p	AGOS_ACR022W, Syntenic homolog of Saccharomyces cerevisiae YPL270W (MDL2)
ERGO0F15840p	AGOS_AFR432W, Syntenic homolog of Saccharomyces cerevisiae YKL209C (STE6)
ERGO0F21802p	AGOS_AFR683C, Syntenic homolog of Saccharomyces cerevisiae YLR188W (MDL1)
ERGO0G00880p	AGOS_AGL335W, Syntenic homolog of Saccharomyces cerevisiae YMR301C (ATM1)
DEHA2B03894p	similar to uniprot|P40416 Saccharomyces cerevisiae YMR301C ATM1 mitochondrial inner membrane transporter; RecName: Full=Iron-sulfur clusters transporter ATM1, mitochondrial; Flags: Precursor;
DEHA2B07172p	weakly similar to uniprot|P33311 Saccharomyces cerevisiae YPL270W MDL2 Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane; SubName: Full=DEHA2B07172p;
DEHA2E23760p	similar to uniprot|P33310 Saccharomyces cerevisiae YLR188W MDL1 Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane; SubName: Full=DEHA2E23760p;
DEHA2F17226p	similar to uniprot|P12866 Saccharomyces cerevisiae YKL209C STE6 ATP-binding cassette (ABC) transporter required for the export of a-factor; SubName: Full=DEHA2F17226p;
PISO0A08030p
PISO0B08097p
PISO0I06388p
PISO0J08193p
PISO0M08064p
PISO0M12134p
PISO0N08219p
PISO0N12443p
YALI0A11473p	weakly similar to uniprot|P12866 Saccharomyces cerevisiae YKL209c STE6 ATP-binding cassette transporter protein; SubName: Full=YALI0A11473p;
YALI0B12188p	weakly similar to uniprot|P12866 Saccharomyces cerevisiae YKL209c STE6 ATP-binding cassette transporter protein; SubName: Full=YALI0B12188p;
YALI0E00880p	similar to uniprot|O43129 Aspergillus fumigatus MDR2 Multidrug resistance protein 2 possible transmembrane segment; SubName: Full=YALI0E00880p;
YALI0E05973p	similar to uniprot|P12866 Saccharomyces cerevisiae YKL209c STE6 ATP-binding cassette transporter protein; SubName: Full=YALI0E05973p;
YALI0E08030p	similar to uniprot|P40416 Saccharomyces cerevisiae YMR301c ATM1 ATP-binding cassette transporter protein mitochondrial; RecName: Full=Iron-sulfur clusters transporter ATM1, mitochondrial; Flags: Precursor;
YALI0F20174p	similar to uniprot|Q9Y8G1 Emericella nidulans Multidrug resistance protein MDR (ABC-transporter); SubName: Full=YALI0F20174p;

Gene Ontology terms  

None available yet

Data  

Pairwise distances

Amino-acid sequences

Multiple sequence alignment

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Legend and notes  

Type of family, see Definitions for more information.

GL3R*	Robust families
GL3C*	Consensus families
GL3M*	Multiple choice families (resolved arbitrarily in favor of smaller groups)
GL3U*	Unique element families (singletons)

Phyletic pattern
This pattern is an ordered chain of letters indicating which species are involved in the family. A letter indicates that the species is present, a dash in place of the letter shows that the species is absent.

Letter	Species
s	Saccharomyces cerevisiae
c	Candida glabrata
z	Zygosaccharomyces rouxii
l	Saccharomyces kluyveri
t	Kluyveromyces thermotolerans
k	Kluyveromyces lactis var. lactis
g	Eremothecium gossypii
d	Debaryomyces hansenii var. hansenii
y	Yarrowia lipolytica

Phylogenetic profile
This profile is an ordered chain of numbers indicating how many proteins of each species are present in the family. The order of the numbers is the same as the order in the phyletic pattern (see above).

Family relations
Click on a node of the image to go to the page of the corresponding gene. The weight of an edge between two genes is the percent amino-acid identity in a Needleman Wunch global alignment between the translation products of the two genes. The graph shown is the subgraph induces by edges with weight ≥ 20%.

Data
Colored multiple sequence alignments are computed using TCoffee.