SACE0D10252g

5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p

Genomic environment map

Element type: CDS
Element length: 1647 nucleotides,
on sense strand of
Sace0D: 927448..929094.
Other names:
CYD1
HEM1
YDR232W
Coding sequence: 549 codons.

Database cross references:
ArrayExpress: P09950
CYGD: YDR232w
EMBL: AAA34668.1
EMBL: CAA88511.1
EMBL: J03556
EMBL: M26329
EMBL: Z48612
Ensembl: YDR232W
GeneID: 851818
GenomeReviews: Z71256_GR
HOGENOM: P09950
NMPDR: fig|4932.3.peg.1275

Computed results

None available yet

Homologs and Orthologs

Génolevures family GL3C0100
Consensus family of 28 members, scrltkgdy (3 3 3 3 3 3 3 3 4)
28-member family, phyletic pattern sczltkgdy, profile (3 3 3 3 3 3 3 3 4)
Proteins: SACE0D06688p SACE0D10252p SACE0M10164p CAGL0B02607p CAGL0G00440p CAGL0G05071p ZYRO0A10032p ZYRO0D07282p ZYRO0G09152p SAKL0H01144p SAKL0H12364p SAKL0H19272p KLTH0B09306p KLTH0E10538p KLTH0H07920p KLLA0A09955p KLLA0C15059p KLLA0D02134p ERGO0B02486p ERGO0B08624p ERGO0G11220p DEHA2B05478p DEHA2E02134p DEHA2F24926p YALI0C03179p YALI0C06083p YALI0E17545p YALI0F15345p
Search in: Génolevures Google

Génolevures family GL3C0100.N2
Nine-SONS subgroup of a Consensus family
9-member family, phyletic pattern sczltkgdy, profile (1 1 1 1 1 1 1 1 1)
Proteins: SACE0D10252p CAGL0B02607p ZYRO0A10032p SAKL0H12364p KLTH0E10538p KLLA0C15059p ERGO0B02486p DEHA2E02134p YALI0C03179p
Search in: Génolevures Google

Homologs in protein families: GL3C0100 GL3C0100.N2
Orthologs: strict determination not possible; homologs must be refined manually

Protein SACE0D10252p

Protein domain map

Protein length: 548 amino acids
Protein family: GL3C0100

Database cross references:
Gene3D: G3DSA:3.40.640.10
GermOnline: YDR232W
HSSP: 1FC4
HSSP: P07912
IntAct: P09950
InterPro: IPR001917
InterPro: IPR004839
InterPro: IPR010961
InterPro: IPR015421
KEGG: sce:YDR232W
LinkHub: P09950
PIR: A24870
PROSITE: PS00599
PeptideAtlas: P09950
Pfam: PF00155
RefSeq: NP_010518.1
SGD: S000002640
TIGRFAMs: TIGR01821
UniProtKB/Swiss-Prot: P09950
UniprotKB: HEM1_YEAST

Computed results for SACE0D10252p

Blastp Genolevures

Blastp Uniprot

Gene Ontology terms

GO:0045449	regulation of transcription
GO:0006783	heme biosynthetic process
GO:0005759	mitochondrial matrix
GO:0003870	5-aminolevulinate synthase activity

Sequence data

>SACE0D10252g.nt
CACGGTTTCCTTTGCCAATTGTGCGATCTGGAAACTTTTTTGTCTCTTTAGCCTACATTG
CTCCCATCCGACAATCGAGCCCAGTATCAGAGAGCTCATCGCCCAATTCGTGGCCTTAGT
CGGGCTCTTATGGTATATAAATATAATAGATCCCATCAAGAACATGCTGGAAAACCCGAG
CATGCCCGCGTCTCTGAAGCACGGGATTGAAGTCAGCTTCTGCAAACTAAAATCACTCCA
TCTGATCGAGTCCCAAGCCTCTTTCAAAGTAGCCCGTTCTTGCTTCTTGGCCAACTGAGA
ATTGGACAAGTCATCGGCAAACTTGGGTGGAGTGTCTTCTAAGAGGATCTTTTGACCCCG
CGAGTAATTTGTCAGCACGCGATCACCATCTGCTTTACCCTGCGGTTGTTGCTGCTGCTT
TTGATCTTCTGTCTGATTTGACCACGGCCACCAACGCATCTTTATATTAACTGTTGAGCT
GCTCGTTACGCACTGCTGTGGACTTCACTACAATGCTTTACCGAGCAGTGGAGTTTGATA
TAGTGGTGGTACCCCCGACGGTGCTATAATAAGCTTGCCTGCACGGCTTACCCTACCGCT
CGGAAAGGCCGCCTTCGTCGCTCATTGGTCTGCGGCCGCGGGCGCTTTTTGGTCATTGTT
CATATATGAAGAAAGAGCAGGAACGGAAATTTTTCATCTTGCCTTGCCCATTGTTCTGAT
CCATGCGTTGTTAGAAATACAACGTTTGCATCATACCAAACTTCTCCATTCCGTCAGCTG
ATACTCTATTCGGTTGTGTGTTGCACCCTGCTCTGCTGTCTCTCAACCGTTCTTCCTTTA
CACGCCTTCCCTTCTCAGCTCGCGTTTCTTTTTTTTTTATCCCACTCTTTTCTTTTTTCT
TTCCTATATATTGCCCATATAAGTTTGGTTGGAAGGAAAACTAATAGAGCTAGTTGTTGT
CCCTCAATAATCATAACAGTACTTAGGTTTTTTTTTCAGTATGCAACGCTCCATTTTTGC
GAGGTTCGGTAACTCCTCTGCCGCTGTTTCCACACTGAATAGGCTGTCCACGACAGCCGC
ACCACATGCGAAAAATGGCTATGCCACCGCTACTGGTGCTGGTGCCGCTGCTGCCACTGC
CACAGCGTCATCAACACATGCAGCAGCAGCAGCAGCCGCTGCTGCCAACCATTCCACCCA
GGAGTCGGGTTTCGATTACGAAGGCCTGATAGATTCCGAACTGCAGAAGAAAAGACTTGA
CAAATCGTACAGATATTTCAACAATATCAACCGATTGGCCAAGGAGTTCCCCCTAGCTCA
TCGCCAGAGAGAGGCGGACAAGGTCACCGTTTGGTGTTCCAACGACTATTTAGCACTTTC
CAAGCACCCTGAGGTATTGGACGCCATGCATAAAACTATCGACAAGTATGGTTGTGGTGC
CGGTGGTACAAGAAACATTGCTGGCCATAACATCCCCACTTTGAATCTGGAAGCCGAATT
GGCCACTTTACACAAGAAGGAAGGTGCCTTAGTTTTTTCGTCATGTTACGTAGCCAACGA
TGCCGTCTTATCCCTACTGGGTCAAAAGATGAAGGACTTGGTGATTTTCTCCGACGAACT
CAACCATGCGTCCATGATTGTCGGTATTAAGCATGCTAACGTAAAAAAACACATTTTCAA
ACATAATGACTTGAACGAATTGGAACAACTGCTCCAGTCATACCCCAAATCCGTTCCTAA
ACTAATTGCTTTCGAATCAGTATATTCTATGGCCGGTTCAGTGGCCGACATAGAAAAAAT
TTGCGACTTGGCCGACAAATACGGTGCTTTGACCTTCTTGGATGAAGTACATGCGGTCGG
CCTGTACGGCCCTCACGGTGCAGGTGTTGCAGAACATTGTGATTTTGAAAGTCACCGTGC
AAGTGGTATTGCTACCCCAAAGACCAATGACAAGGGCGGCGCGAAGACTGTGATGGACCG
TGTCGACATGATCACCGGCACTTTAGGTAAGTCTTTCGGTAGCGTAGGTGGCTACGTCGC
AGCCTCTAGGAAATTGATCGATTGGTTCAGATCGTTTGCACCTGGTTTCATTTTCACCAC
GACTTTACCACCTTCAGTTATGGCAGGCGCTACCGCAGCAATTAGATACCAACGTTGCCA
CATCGACCTAAGAACCTCGCAACAGAAACATACCATGTACGTAAAGAAAGCTTTCCATGA
GTTGGGCATTCCAGTTATTCCAAATCCTTCTCATATCGTCCCAGTGTTGATTGGTAATGC
TGATTTGGCTAAGCAAGCTTCTGACATCTTAATCAATAAGCATCAAATCTACGTACAAGC
TATCAACTTCCCTACGGTTGCTCGCGGTACCGAAAGATTGAGAATTACCCCAACGCCAGG
TCACACCAACGATTTATCTGACATCTTAATCAATGCAGTTGATGATGTGTTCAATGAGCT
ACAGTTACCACGTGTCAGAGACTGGGAAAGCCAAGGTGGCTTATTGGGTGTTGGAGAGAG
CGGATTTGTGGAAGAGTCTAACTTATGGACATCAAGCCAACTATCTTTAACTAATGACGA
CTTGAACCCTAATGTTAGAGACCCCATCGTTAAACAACTAGAGGTTTCTAGTGGTATCAA
GCAGTAAAACAACCAATATATGCATGGGCTGAGATAGAGGTACAAGGAATTTGTAAATCA
GTAAAAAAAAAAATTAACAGTTTTTTTTTTTCATTTTTTTTTTTTATTCTTATTTATGTA
TGATACTTTATTATTATTTCTCTTAATTATTTATTTATTTAACTAACACGATGAGCACTT
TTAACTGCAATGGTTAAACTGTAGCAATGTTGGTAAAAAAGCAGGGAAAGTTCAAAAATA
ATTTATGTATTTTTCCTCGGGGGTACAGAAAGTAAAGAGAGAGAAACGTATGAGTATATA
TAGGCTA

>SACE0D10252g.cds
ATGCAACGCTCCATTTTTGCGAGGTTCGGTAACTCCTCTGCCGCTGTTTCCACACTGAAT
AGGCTGTCCACGACAGCCGCACCACATGCGAAAAATGGCTATGCCACCGCTACTGGTGCT
GGTGCCGCTGCTGCCACTGCCACAGCGTCATCAACACATGCAGCAGCAGCAGCAGCCGCT
GCTGCCAACCATTCCACCCAGGAGTCGGGTTTCGATTACGAAGGCCTGATAGATTCCGAA
CTGCAGAAGAAAAGACTTGACAAATCGTACAGATATTTCAACAATATCAACCGATTGGCC
AAGGAGTTCCCCCTAGCTCATCGCCAGAGAGAGGCGGACAAGGTCACCGTTTGGTGTTCC
AACGACTATTTAGCACTTTCCAAGCACCCTGAGGTATTGGACGCCATGCATAAAACTATC
GACAAGTATGGTTGTGGTGCCGGTGGTACAAGAAACATTGCTGGCCATAACATCCCCACT
TTGAATCTGGAAGCCGAATTGGCCACTTTACACAAGAAGGAAGGTGCCTTAGTTTTTTCG
TCATGTTACGTAGCCAACGATGCCGTCTTATCCCTACTGGGTCAAAAGATGAAGGACTTG
GTGATTTTCTCCGACGAACTCAACCATGCGTCCATGATTGTCGGTATTAAGCATGCTAAC
GTAAAAAAACACATTTTCAAACATAATGACTTGAACGAATTGGAACAACTGCTCCAGTCA
TACCCCAAATCCGTTCCTAAACTAATTGCTTTCGAATCAGTATATTCTATGGCCGGTTCA
GTGGCCGACATAGAAAAAATTTGCGACTTGGCCGACAAATACGGTGCTTTGACCTTCTTG
GATGAAGTACATGCGGTCGGCCTGTACGGCCCTCACGGTGCAGGTGTTGCAGAACATTGT
GATTTTGAAAGTCACCGTGCAAGTGGTATTGCTACCCCAAAGACCAATGACAAGGGCGGC
GCGAAGACTGTGATGGACCGTGTCGACATGATCACCGGCACTTTAGGTAAGTCTTTCGGT
AGCGTAGGTGGCTACGTCGCAGCCTCTAGGAAATTGATCGATTGGTTCAGATCGTTTGCA
CCTGGTTTCATTTTCACCACGACTTTACCACCTTCAGTTATGGCAGGCGCTACCGCAGCA
ATTAGATACCAACGTTGCCACATCGACCTAAGAACCTCGCAACAGAAACATACCATGTAC
GTAAAGAAAGCTTTCCATGAGTTGGGCATTCCAGTTATTCCAAATCCTTCTCATATCGTC
CCAGTGTTGATTGGTAATGCTGATTTGGCTAAGCAAGCTTCTGACATCTTAATCAATAAG
CATCAAATCTACGTACAAGCTATCAACTTCCCTACGGTTGCTCGCGGTACCGAAAGATTG
AGAATTACCCCAACGCCAGGTCACACCAACGATTTATCTGACATCTTAATCAATGCAGTT
GATGATGTGTTCAATGAGCTACAGTTACCACGTGTCAGAGACTGGGAAAGCCAAGGTGGC
TTATTGGGTGTTGGAGAGAGCGGATTTGTGGAAGAGTCTAACTTATGGACATCAAGCCAA
CTATCTTTAACTAATGACGACTTGAACCCTAATGTTAGAGACCCCATCGTTAAACAACTA
GAGGTTTCTAGTGGTATCAAGCAGTAA

>SACE0D10252g.aa
MQRSIFARFGNSSAAVSTLNRLSTTAAPHAKNGYATATGAGAAAATATASSTHAAAAAAA
AANHSTQESGFDYEGLIDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCS
NDYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFS
SCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQS
YPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHC
DFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFA
PGFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVIPNPSHIV
PVLIGNADLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILINAV
DDVFNELQLPRVRDWESQGGLLGVGESGFVEESNLWTSSQLSLTNDDLNPNVRDPIVKQL
EVSSGIKQ*

Legend and notes

Lengths
The length, in codons, of coding sequences includes the stop codon, hence it is one unit longer than the protein length.

Genomic environment map
Click on the symbol of an element or a family to go to its corresponding page. Colors in the lane "protein encoding genes" indicate strandedness: shades of blue for direct orientation, shades of red for reverse orientation. Colors in the lane "protein family" are arbitrarly chosen in such a way that different protein families have different colors in the map.

Protein domain map
Domains are extracted from SwissProt files. Click on the symbol of a domain to extract the domain sequence.

Genemark image and list
Genemark computation of protein-coding potential of DNA was made from 1000 nucleotides upstream the open reading frame to 300 nucleotides downstream. Thus the open reading frame protein-coding potential appears on frame #3.

Sequences

Color	Nucleotide sequence and Coding sequence	Predicted translation product
RED	start and stop codons	Initial methionine and sequence end
BLUE	coding sequence	protein sequence
grey	non-coding sequence (upstream, downstream or intron)
grey	donor and acceptor splicing sites

Genetic Elements

SACE0D10252g

SACE0D10252g

Genomic environment map

Computed results

Homologs and Orthologs

Protein SACE0D10252p

Protein domain map

Computed results for SACE0D10252p

Gene Ontology terms

Sequence data

Nucleotide sequence

Coding sequence

Predicted translation product

Legend and notes