HomeSACE0D09856g
Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
Element type: CDS
Element length: 2139 nucleotides,
on sense strand of
Sace0D: 884724..886862.
Other names:
GCD6
YDR211W
Coding sequence: 713 codons.
Element length: 2139 nucleotides,
on sense strand of
Sace0D: 884724..886862.
Other names:
GCD6
YDR211W
Coding sequence: 713 codons.
Database cross references:
ArrayExpress: P32501
CYGD: YDR211w
EMBL: AAA65498.1
EMBL: CAA92354.1
EMBL: CAA92362.1
EMBL: L07115
EMBL: Z68194
EMBL: Z68195
Ensembl: YDR211W
GeneID: 851797
GenomeReviews: Z71256_GR
HOGENOM: P32501
NMPDR: fig|4932.3.peg.1254
Orthologs: strict determination not possible; homologs must be refined manually
ArrayExpress: P32501
CYGD: YDR211w
EMBL: AAA65498.1
EMBL: CAA92354.1
EMBL: CAA92362.1
EMBL: L07115
EMBL: Z68194
EMBL: Z68195
Ensembl: YDR211W
GeneID: 851797
GenomeReviews: Z71256_GR
HOGENOM: P32501
NMPDR: fig|4932.3.peg.1254
Homologs and Orthologs
Homologs in protein families: GL3C0213 GL3C0213.N2Orthologs: strict determination not possible; homologs must be refined manually
Protein SACE0D09856p 
Protein domain map
Database cross references:
DIP: DIP:2328N
Gene3D: G3DSA:1.25.40.230
GermOnline: YDR211W
IntAct: P32501
InterPro: IPR001451
InterPro: IPR003307
InterPro: IPR005835
KEGG: sce:YDR211W
LinkHub: P32501
PDB: 1PAQ
PDBsum: 1PAQ
PIR: A48156
PROSITE: PS51363
PeptideAtlas: P32501
Pfam: PF00132
Pfam: PF00483
Pfam: PF02020
RefSeq: NP_010497.1
SGD: S000002619
SMART: SM00515
UniProtKB/Swiss-Prot: P32501
UniprotKB: EI2BE_YEAST
DIP: DIP:2328N
Gene3D: G3DSA:1.25.40.230
GermOnline: YDR211W
IntAct: P32501
InterPro: IPR001451
InterPro: IPR003307
InterPro: IPR005835
KEGG: sce:YDR211W
LinkHub: P32501
PDB: 1PAQ
PDBsum: 1PAQ
PIR: A48156
PROSITE: PS51363
PeptideAtlas: P32501
Pfam: PF00132
Pfam: PF00483
Pfam: PF02020
RefSeq: NP_010497.1
SGD: S000002619
SMART: SM00515
UniProtKB/Swiss-Prot: P32501
UniprotKB: EI2BE_YEAST
Gene Ontology terms
| GO:0032045 | guanyl-nucleotide exchange factor complex |
| GO:0006446 | regulation of translational initiation |
| GO:0005851 | eukaryotic translation initiation factor 2B complex |
| GO:0005085 | guanyl-nucleotide exchange factor activity |
| GO:0003743 | translation initiation factor activity |
Sequence data
Nucleotide sequence
>SACE0D09856g.nt GGGGTTCTCTGGAACAGCTGATGAAGCAGGTGTTGTTGTCTGTTGAGAGTTAGCCTTAGT GGAAGCCTTATCATATTCTTGAATTTTGGAAGCTGAAACGTCTAACGGATCTTGATTTGT GTGGACTTCCTTAGAAGTAACCGAAGCACAGGCGCTACCATGAGATATATGTGGGTAATT AGATAATTGTTGGGATTCCATTGTTGATAAAGGCTATAATATTAGGTATACAGAATATAC TAGAAGTTCTCCTCGAGGATTTAGGAATCCATAAAAGGGAATCTGCAATTCTACACAATT CTATAAATATTATTATCATCGTTTTATATGTTAATATTCATTGATCCTATTACATTATCA ATCCTTGCGTTTCAGCTTCCACTAATTTAGATGACTATTTCTCATCATTTGCGTCATCTT CTAACACCGTATATGATAATATACTAGTAACGTAAATACTAGTTAGTAGATGATAGTTGA TTTTTATTCCAACAATGGCCTCTTTAACACTAATATCCCGACAATTTTCCCAAAATTCAA AGAATTCTCAGAAAGAGCTATTTTTTTTTTTAATAAAATTATTAGTACTAATTCCAGTAT AAATAACAATGTTATTTACGTCTCTTTCGAAAATGCTCGTGTAGCTCAGTGGTTAGAGCT TCGTGCTTATAGCAACATTCGGTTTCCGAAGTTTCTGTGCCAAAGACCTTTCAAACAGGC CTTTAAAAGCAACGCGACCGTCGTGGGTTCAAACCCCACCTCGAGCACTTTCTCTTTTTT TTTCACACGCGTTTGCAACATGCCCGTATTACATGAGCTTATTTGACTTTAGATGGTTTT CAGTTCTTTTTTTTTTTTTTTTTTTTTTCAGTAGATTAATGCGAAGAGTTAAATCACCAA TTCAAAGATGGCAGATGGACCACCTTGTGGGATAAGTATAAAAATAACTAAAAGTGGTCT TGTGTTAAAAATAGAATAGAAACCACTCATAAGGCAAAAGATGGCTGGAAAAAAGGGACA AAAGAAAAGTGGACTAGGCAACCATGGAAAGAACTCTGATATGGATGTTGAAGATCGTCT CCAGGCCGTTGTCTTGACAGACTCTTATGAAACTAGGTTTATGCCACTGACAGCTGTCAA GCCAAGGTGTTTGCTGCCACTGGCTAACGTACCTCTCATTGAATACACCTTAGAATTTTT GGCTAAGGCTGGCGTACATGAAGTTTTCTTAATTTGCTCTTCTCATGCCAACCAAATTAA TGACTATATTGAGAATTCTAAGTGGAACTTGCCTTGGTCTCCATTTAAAATTACCACCAT TATGTCTCCAGAAGCTAGATGTACGGGTGATGTTATGAGAGATCTAGATAATAGAGGTAT CATTACTGGAGATTTTATTTTAGTCAGTGGTGATGTATTGACTAACATCGATTTCAGCAA AATGCTAGAATTTCACAAAAAAATGCATTTGCAAGATAAAGATCACATCTCGACAATGTG TTTGAGCAAAGCGAGTACCTATCCAAAAACAAGAACTATTGAGCCTGCCGCATTTGTCTT AGACAAATCCACCAGTAGGTGTATTTATTACCAAGATTTACCATTACCAAGCTCTAGAGA GAAGACTTCCATTCAGATTGACCCAGAATTGTTGGATAATGTCGATGAATTTGTCATAAG GAATGACCTCATCGATTGTAGAATTGACATTTGTACATCTCATGTACCTTTGATATTTCA AGAAAATTTTGACTACCAATCATTAAGGACAGACTTTGTTAAAGGTGTCATTTCAAGCGA TATATTGGGAAAGCATATATATGCCTATTTGACGGACGAATATGCTGTAAGAGTTGAAAG TTGGCAAACTTACGACACCATTTCTCAAGACTTTTTAGGTAGATGGTGTTATCCCTTGGT CTTAGACTCTAACATACAGGACGATCAAACGTATTCTTATGAATCAAGACATATATACAA GGAAAAAGACGTTGTTTTGGCCCAATCCTGTAAAATTGGTAAGTGCACTGCAATTGGATC AGGAACAAAAATCGGAGAGGGTACGAAAATTGAGAATTCCGTGATTGGAAGGAACTGCCA AATCGGTGAAAATATTAGAATCAAGAACAGTTTCATTTGGGATGACTGTATCATCGGAAA TAACAGTATAATTGACCATTCATTAATTGCCTCTAATGCCACGTTAGGGAGTAATGTACG CCTAAATGATGGCTGTATAATTGGTTTCAACGTTAAAATTGATGATAATATGGATTTAGA TAGAAACACAAAAATATCTGCCAGTCCATTAAAAAATGCCGGCTCAAGAATGTATGATAA TGAAAGCAATGAGCAGTTTGACCAAGACCTTGATGATCAGACACTAGCCGTTTCTATTGT TGGAGATAAGGGTGTTGGTTATATTTACGAAAGCGAGGTGTCTGACGATGAAGATAGTTC TACAGAAGCCTGCAAAGAAATAAACACTTTGAGTAACCAATTAGATGAGTTATACTTAAG TGACGATTCAATTTCTTCCGCCACTAAAAAGACAAAGAAAAGAAGAACGATGTCTGTCAA TAGTATATACACGGATAGAGAAGAAATTGATTCTGAATTTGAGGACGAAGATTTTGAGAA AGAAGGTATTGCCACCGTGGAGCGTGCTATGGAAAACAATCATGATCTTGACACAGCATT ATTAGAATTGAACACCTTGAGAATGAGTATGAACGTGACATATCATGAGGTGAGAATAGC AACAATAACTGCATTATTGAGAAGAGTTTACCACTTTATTGCAACTCAAACATTAGGTCC CAAGGACGCTGTGGTGAAGGTTTTTAATCAGTGGGGACTGTTGTTCAAGAGACAAGCCTT TGATGAAGAAGAGTATATTGATTTGATGAACATCATAATGGAAAAAATTGTAGAACAGAG TTTTGACAAACCGGATTTGATTCTATTTAGTGCATTGGTTTCTCTATACGATAATGACAT AATTGAGGAGGATGTCATTTATAAATGGTGGGATAATGTTTCTACTGACCCTCGCTATGA TGAAGTCAAGAAATTAACTGTAAAGTGGGTTGAGTGGTTACAGAATGCTGACGAAGAATC TTCCTCAGAAGAGGAATAAAAGTCCACGCAGTACCCTGCATAATCATGTATTACCATAAA AAGGCTTTAATATGAGAAAAAGGTGAGCGCTATATAGATTTAGTAATTTACATGTTACAG AAGCAAAAAGCAAATATATATATATTTTTTATCATATTAGTTTTTATCCTCAGTAGTACT ACTGAAATAATAATCTCAGATTTTTTTTTTTCACTTGCCGAGGGACCTTGTCCTAAGTGG CAAAGAACTGAAAAAAAAAAAAATTGAAATGCGGTGGTATCACATGAAGAGTAAATAACT TAAGCAAAAGAGAGGCCAC
Coding sequence
>SACE0D09856g.cds ATGGCTGGAAAAAAGGGACAAAAGAAAAGTGGACTAGGCAACCATGGAAAGAACTCTGAT ATGGATGTTGAAGATCGTCTCCAGGCCGTTGTCTTGACAGACTCTTATGAAACTAGGTTT ATGCCACTGACAGCTGTCAAGCCAAGGTGTTTGCTGCCACTGGCTAACGTACCTCTCATT GAATACACCTTAGAATTTTTGGCTAAGGCTGGCGTACATGAAGTTTTCTTAATTTGCTCT TCTCATGCCAACCAAATTAATGACTATATTGAGAATTCTAAGTGGAACTTGCCTTGGTCT CCATTTAAAATTACCACCATTATGTCTCCAGAAGCTAGATGTACGGGTGATGTTATGAGA GATCTAGATAATAGAGGTATCATTACTGGAGATTTTATTTTAGTCAGTGGTGATGTATTG ACTAACATCGATTTCAGCAAAATGCTAGAATTTCACAAAAAAATGCATTTGCAAGATAAA GATCACATCTCGACAATGTGTTTGAGCAAAGCGAGTACCTATCCAAAAACAAGAACTATT GAGCCTGCCGCATTTGTCTTAGACAAATCCACCAGTAGGTGTATTTATTACCAAGATTTA CCATTACCAAGCTCTAGAGAGAAGACTTCCATTCAGATTGACCCAGAATTGTTGGATAAT GTCGATGAATTTGTCATAAGGAATGACCTCATCGATTGTAGAATTGACATTTGTACATCT CATGTACCTTTGATATTTCAAGAAAATTTTGACTACCAATCATTAAGGACAGACTTTGTT AAAGGTGTCATTTCAAGCGATATATTGGGAAAGCATATATATGCCTATTTGACGGACGAA TATGCTGTAAGAGTTGAAAGTTGGCAAACTTACGACACCATTTCTCAAGACTTTTTAGGT AGATGGTGTTATCCCTTGGTCTTAGACTCTAACATACAGGACGATCAAACGTATTCTTAT GAATCAAGACATATATACAAGGAAAAAGACGTTGTTTTGGCCCAATCCTGTAAAATTGGT AAGTGCACTGCAATTGGATCAGGAACAAAAATCGGAGAGGGTACGAAAATTGAGAATTCC GTGATTGGAAGGAACTGCCAAATCGGTGAAAATATTAGAATCAAGAACAGTTTCATTTGG GATGACTGTATCATCGGAAATAACAGTATAATTGACCATTCATTAATTGCCTCTAATGCC ACGTTAGGGAGTAATGTACGCCTAAATGATGGCTGTATAATTGGTTTCAACGTTAAAATT GATGATAATATGGATTTAGATAGAAACACAAAAATATCTGCCAGTCCATTAAAAAATGCC GGCTCAAGAATGTATGATAATGAAAGCAATGAGCAGTTTGACCAAGACCTTGATGATCAG ACACTAGCCGTTTCTATTGTTGGAGATAAGGGTGTTGGTTATATTTACGAAAGCGAGGTG TCTGACGATGAAGATAGTTCTACAGAAGCCTGCAAAGAAATAAACACTTTGAGTAACCAA TTAGATGAGTTATACTTAAGTGACGATTCAATTTCTTCCGCCACTAAAAAGACAAAGAAA AGAAGAACGATGTCTGTCAATAGTATATACACGGATAGAGAAGAAATTGATTCTGAATTT GAGGACGAAGATTTTGAGAAAGAAGGTATTGCCACCGTGGAGCGTGCTATGGAAAACAAT CATGATCTTGACACAGCATTATTAGAATTGAACACCTTGAGAATGAGTATGAACGTGACA TATCATGAGGTGAGAATAGCAACAATAACTGCATTATTGAGAAGAGTTTACCACTTTATT GCAACTCAAACATTAGGTCCCAAGGACGCTGTGGTGAAGGTTTTTAATCAGTGGGGACTG TTGTTCAAGAGACAAGCCTTTGATGAAGAAGAGTATATTGATTTGATGAACATCATAATG GAAAAAATTGTAGAACAGAGTTTTGACAAACCGGATTTGATTCTATTTAGTGCATTGGTT TCTCTATACGATAATGACATAATTGAGGAGGATGTCATTTATAAATGGTGGGATAATGTT TCTACTGACCCTCGCTATGATGAAGTCAAGAAATTAACTGTAAAGTGGGTTGAGTGGTTA CAGAATGCTGACGAAGAATCTTCCTCAGAAGAGGAATAA
Predicted translation product
>SACE0D09856g.aa MAGKKGQKKSGLGNHGKNSDMDVEDRLQAVVLTDSYETRFMPLTAVKPRCLLPLANVPLI EYTLEFLAKAGVHEVFLICSSHANQINDYIENSKWNLPWSPFKITTIMSPEARCTGDVMR DLDNRGIITGDFILVSGDVLTNIDFSKMLEFHKKMHLQDKDHISTMCLSKASTYPKTRTI EPAAFVLDKSTSRCIYYQDLPLPSSREKTSIQIDPELLDNVDEFVIRNDLIDCRIDICTS HVPLIFQENFDYQSLRTDFVKGVISSDILGKHIYAYLTDEYAVRVESWQTYDTISQDFLG RWCYPLVLDSNIQDDQTYSYESRHIYKEKDVVLAQSCKIGKCTAIGSGTKIGEGTKIENS VIGRNCQIGENIRIKNSFIWDDCIIGNNSIIDHSLIASNATLGSNVRLNDGCIIGFNVKI DDNMDLDRNTKISASPLKNAGSRMYDNESNEQFDQDLDDQTLAVSIVGDKGVGYIYESEV SDDEDSSTEACKEINTLSNQLDELYLSDDSISSATKKTKKRRTMSVNSIYTDREEIDSEF EDEDFEKEGIATVERAMENNHDLDTALLELNTLRMSMNVTYHEVRIATITALLRRVYHFI ATQTLGPKDAVVKVFNQWGLLFKRQAFDEEEYIDLMNIIMEKIVEQSFDKPDLILFSALV SLYDNDIIEEDVIYKWWDNVSTDPRYDEVKKLTVKWVEWLQNADEESSSEEE*
Legend and notes
Lengths
The length, in codons, of coding sequences includes the stop codon, hence it is one unit longer than the protein length.
Genomic environment map
Click on the symbol of an element or a family to go to its corresponding page. Colors in the lane "protein encoding genes" indicate strandedness: shades of blue for direct orientation, shades of red for reverse orientation. Colors in the lane "protein family" are arbitrarly chosen in such a way that different protein families have different colors in the map.
Protein domain map
Domains are extracted from SwissProt files. Click on the symbol of a domain to extract the domain sequence.
Genemark image and list
Genemark computation of protein-coding potential of DNA was made from 1000 nucleotides upstream the open reading frame to 300 nucleotides downstream. Thus the open reading frame protein-coding potential appears on frame #3.
Sequences
| Color | Nucleotide sequence and Coding sequence | Predicted translation product |
| RED | start and stop codons | Initial methionine and sequence end |
| BLUE | coding sequence | protein sequence |
| grey | non-coding sequence (upstream, downstream or intron) | |
| grey | donor and acceptor splicing sites |
URL: http://www.genolevures.org/elt/SACE/SACE0D09856p