HomeSACE0B00440g
Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease
Element type: CDS
Element length: 1383 nucleotides,
on sense strand of
Sace0B: 39142..40524.
Other names:
BNA4
YBL098W
Coding sequence: 461 codons.
Element length: 1383 nucleotides,
on sense strand of
Sace0B: 39142..40524.
Other names:
BNA4
YBL098W
Coding sequence: 461 codons.
Database cross references:
CYGD: YBL098w
EMBL: AAT92970.1
EMBL: AY692951
EMBL: CAA56002.1
EMBL: CAA84920.1
EMBL: X79489
EMBL: Z35859
Ensembl: YBL098W
GeneID: 852179
GenomeReviews: Y13134_GR
HOGENOM: P38169
NMPDR: fig|4932.3.peg.140
Orthologs: strict determination not possible; homologs must be refined manually
CYGD: YBL098w
EMBL: AAT92970.1
EMBL: AY692951
EMBL: CAA56002.1
EMBL: CAA84920.1
EMBL: X79489
EMBL: Z35859
Ensembl: YBL098W
GeneID: 852179
GenomeReviews: Y13134_GR
HOGENOM: P38169
NMPDR: fig|4932.3.peg.140
Homologs and Orthologs
Homologs in protein families: GL3R3440 GL3R3440.N2Orthologs: strict determination not possible; homologs must be refined manually
Protein SACE0B00440p 
Protein domain map
Database cross references:
BioCyc: MetaCyc:MON-8166
DIP: DIP:5165N
GermOnline: YBL098W
IntAct: P38169
InterPro: IPR003042
InterPro: IPR006076
KEGG: sce:YBL098W
LinkHub: P38169
PIR: S45402
PRINTS: PR00420
PeptideAtlas: P38169
Pfam: PF01266
RefSeq: NP_009454.1
SGD: S000000194
UniProtKB/Swiss-Prot: P38169
UniprotKB: KMO_YEAST
BioCyc: MetaCyc:MON-8166
DIP: DIP:5165N
GermOnline: YBL098W
IntAct: P38169
InterPro: IPR003042
InterPro: IPR006076
KEGG: sce:YBL098W
LinkHub: P38169
PIR: S45402
PRINTS: PR00420
PeptideAtlas: P38169
Pfam: PF01266
RefSeq: NP_009454.1
SGD: S000000194
UniProtKB/Swiss-Prot: P38169
UniprotKB: KMO_YEAST
Gene Ontology terms
| GO:0034354 | de novo NAD biosynthetic process |
| GO:0005741 | mitochondrial outer membrane |
| GO:0005515 | protein binding |
| GO:0004502 | kynurenine 3-monooxygenase activity |
Sequence data
Nucleotide sequence
>SACE0B00440g.nt GAAACCCAAGGTGGTGATGTCTCCGCTTATATTCCAACCAATGTTATTTCCATTACCGAT GGTCAAATATTCTTGGAAGCTGAATTATTCTACAAGGGTATCAGACCTGCCATTAACGTT GGTTTGTCCGTTTCTCGTGTCGGTTCCGCTGCTCAAGTTAAGGCTTTGAAGCAAGTCGCT GGTTCCTTGAAATTGTTTTTGGCTCAATACAGAGAAGTCGCTGCTTTTGCTCAATTCGGT TCCGATTTAGATGCCTCCACCAAGCAAACTTTGGTTAGAGGTGAAAGATTGACTCAATTG TTGAAGCAAAACCAATATTCTCCTTTGGCTACAGAAGAACAGGTTCCATTGATTTATGCC GGTGTTAATGGTCATTTGGATGGTATTGAACTATCAAGAATTGGTGAATTTGAGTCCTCC TTTTTGTCCTATCTAAAATCCAATCACAATGAGCTTTTGACCGAAATTAGAGAAAAGGGT GAATTGTCTAAAGAATTGTTGGCATCTCTAAAGAGTGCTACTGAATCATTTGTTGCCACT TTTTAATGTGAACTAAAAAAATAAAAATGAATATAAGGTACGTCTCCAAAAGAAATGTAA ATATAGAAATTTTAAAAAAAAAAACGAAAAAAAACATAACTAAATTTAAAGTGCAGCCCA ACAATAACCCTGAAAAATCTAAATATCTTAGAATTTTTTTATTTTGATTATTATATATTA TTATTATTCTTATGGTAAATAATGCCCCTACTTTTCTTCTAAGGAAGTGAGTTACCACCA AAATAAGGAAATATCGCCTGCAAGCGGTTTTTATTTTGGAGTTGTTTTTTTTTTTCCCAC AATAGCCTCTAGTTTATTCCATTCTTAGCACTGACTCTTTTTTCCGCCACTATTTCTTAT AAAAGGCCCGAATTTCTGGCACGGACGTTGTTTTTAATAATAAAATATTGAATGACAGTT AAAAAATCACGTAGTCAGTTAATCTGTTTAACTTGAAAATATGTCTGAATCAGTGGCCAT TATAGGTGCAGGATTAGTAGGCTGCCTTGCAGCTTTGGCATTCTCCAAAGAAGGCTACAA TGTCACACTATATGATTTTAGACAAGATCCTCGATTGGACACCACCAAAAATAAAAATTT GAAATCCATTAATTTGGCTATTTCTGCTCGTGGCATTGATGCTCTGAAATCAATAGATCC GGATGCTTGTGAACATATTCTGCAAGATATGATTCCCATGAAAGGCAGGATGATTCATGA CTTGAAAGGCAGACAGGAATCACAATTGTATGGCTTGCATGGAGAAGCTATTAATTCTAT CAATAGATCTGTATTAAATAATAGCCTTTTGGACGAATTAGAAAAATCTACAACAGAACT GAAGTTCGGTCACAAATTAGTCAAAATCGAATGGACAGATGATAAACAAATCTGTCATTT TGCCATTGGGGAAGATTTGAAAACCCCACATACTGAAAAGTATGATTTTGTCATAGGTTG TGACGGAGCATACTCTGCGACGAGATCGCAAATGCAACGTAAAGTTGAGATGGATTTTTC ACAAGAATATATGAATTTACGTTACATTGAACTTTACATCCCGCCTACTGAGGAATTCAA GCCAAACTATGGCGGAAATTTTGCAATAGCTCCTGACCATTTGCACATTTGGCCTCGTCA TAAATTCATGTTAATTGCGCTCGCCAACAGTGACGGCTCGTTCACTTCAACCTTTTTCGG TTCTAAAGATCAAATATCAGATCTGATAACTTCCAAGTCACGTGTGAGGGAATTCTTAAT CGAGAACTTTCCCGATATTATTAATATTATGGATTTGGACGATGCTGTCAAAAGGTTTAT CACTTATCCAAAGGAAAGTCTTGTCTGTGTAAACTGTAAGCCATACGATGTACCAGGCGG AAAGGCCATCCTACTCGGCGACGCTGCCCATGCAATGGTTCCATTTTACGGCCAAGGTAT GAATTGCGGATTTGAAGATGTGAGAATTCTTATGGCGCTATTGAAAAAGCATTCAGGAGA TCGTTCAAGAGCCTTTACTGAGTACACTCAAACAAGACATAAGGACCTAGTTTCTATTAC TGAGCTGGCAAAAAGGAACTATAAAGAAATGTCACATGACGTTACATCCAAGCGGTTTTT ATTAAGGAAAAAGCTAGATGCTCTCTTTAGTATTATAATGAAGGATAAGTGGATACCTTT GTATACAATGATATCTTTCAGATCCGATATCTCGTATTCTAGAGCTTTAGAAAGGGCTGG AAAGCAAACACGTATCTTGAAATTCTTAGAATCTCTGACACTCGGTATGTTATCTATTGG CGGTTACAAGCTTTTCAAATTTTTGACAAGAGAACGTTCCTGAAGCCAGTTTATTCTTGC CATCCGTGTACGCTAGGAGAGGATTATTAAAATAAGTGATATATACATATATATATATAT ATATATATATATAATACACTAATTATTTTATGTGATGTTGATCACGCGAAACGGTAAACG GCTCTGTTCGCGCTTTCTTTGTTTACATTTTAGTGAAGTATTGTCAAGATAATATCCATA TGGTTGAACTTTTTATATTGGCTAGTTAAATACTCTATTTATTGCACCAAAAAATCATCT TAGTGGACTTTTTGGAGCAAAAAAAACCAGCAGGTAGTTATAT
Coding sequence
>SACE0B00440g.cds ATGTCTGAATCAGTGGCCATTATAGGTGCAGGATTAGTAGGCTGCCTTGCAGCTTTGGCA TTCTCCAAAGAAGGCTACAATGTCACACTATATGATTTTAGACAAGATCCTCGATTGGAC ACCACCAAAAATAAAAATTTGAAATCCATTAATTTGGCTATTTCTGCTCGTGGCATTGAT GCTCTGAAATCAATAGATCCGGATGCTTGTGAACATATTCTGCAAGATATGATTCCCATG AAAGGCAGGATGATTCATGACTTGAAAGGCAGACAGGAATCACAATTGTATGGCTTGCAT GGAGAAGCTATTAATTCTATCAATAGATCTGTATTAAATAATAGCCTTTTGGACGAATTA GAAAAATCTACAACAGAACTGAAGTTCGGTCACAAATTAGTCAAAATCGAATGGACAGAT GATAAACAAATCTGTCATTTTGCCATTGGGGAAGATTTGAAAACCCCACATACTGAAAAG TATGATTTTGTCATAGGTTGTGACGGAGCATACTCTGCGACGAGATCGCAAATGCAACGT AAAGTTGAGATGGATTTTTCACAAGAATATATGAATTTACGTTACATTGAACTTTACATC CCGCCTACTGAGGAATTCAAGCCAAACTATGGCGGAAATTTTGCAATAGCTCCTGACCAT TTGCACATTTGGCCTCGTCATAAATTCATGTTAATTGCGCTCGCCAACAGTGACGGCTCG TTCACTTCAACCTTTTTCGGTTCTAAAGATCAAATATCAGATCTGATAACTTCCAAGTCA CGTGTGAGGGAATTCTTAATCGAGAACTTTCCCGATATTATTAATATTATGGATTTGGAC GATGCTGTCAAAAGGTTTATCACTTATCCAAAGGAAAGTCTTGTCTGTGTAAACTGTAAG CCATACGATGTACCAGGCGGAAAGGCCATCCTACTCGGCGACGCTGCCCATGCAATGGTT CCATTTTACGGCCAAGGTATGAATTGCGGATTTGAAGATGTGAGAATTCTTATGGCGCTA TTGAAAAAGCATTCAGGAGATCGTTCAAGAGCCTTTACTGAGTACACTCAAACAAGACAT AAGGACCTAGTTTCTATTACTGAGCTGGCAAAAAGGAACTATAAAGAAATGTCACATGAC GTTACATCCAAGCGGTTTTTATTAAGGAAAAAGCTAGATGCTCTCTTTAGTATTATAATG AAGGATAAGTGGATACCTTTGTATACAATGATATCTTTCAGATCCGATATCTCGTATTCT AGAGCTTTAGAAAGGGCTGGAAAGCAAACACGTATCTTGAAATTCTTAGAATCTCTGACA CTCGGTATGTTATCTATTGGCGGTTACAAGCTTTTCAAATTTTTGACAAGAGAACGTTCC TGA
Predicted translation product
>SACE0B00440g.aa MSESVAIIGAGLVGCLAALAFSKEGYNVTLYDFRQDPRLDTTKNKNLKSINLAISARGID ALKSIDPDACEHILQDMIPMKGRMIHDLKGRQESQLYGLHGEAINSINRSVLNNSLLDEL EKSTTELKFGHKLVKIEWTDDKQICHFAIGEDLKTPHTEKYDFVIGCDGAYSATRSQMQR KVEMDFSQEYMNLRYIELYIPPTEEFKPNYGGNFAIAPDHLHIWPRHKFMLIALANSDGS FTSTFFGSKDQISDLITSKSRVREFLIENFPDIINIMDLDDAVKRFITYPKESLVCVNCK PYDVPGGKAILLGDAAHAMVPFYGQGMNCGFEDVRILMALLKKHSGDRSRAFTEYTQTRH KDLVSITELAKRNYKEMSHDVTSKRFLLRKKLDALFSIIMKDKWIPLYTMISFRSDISYS RALERAGKQTRILKFLESLTLGMLSIGGYKLFKFLTRERS*
Legend and notes
Lengths
The length, in codons, of coding sequences includes the stop codon, hence it is one unit longer than the protein length.
Genomic environment map
Click on the symbol of an element or a family to go to its corresponding page. Colors in the lane "protein encoding genes" indicate strandedness: shades of blue for direct orientation, shades of red for reverse orientation. Colors in the lane "protein family" are arbitrarly chosen in such a way that different protein families have different colors in the map.
Protein domain map
Domains are extracted from SwissProt files. Click on the symbol of a domain to extract the domain sequence.
Genemark image and list
Genemark computation of protein-coding potential of DNA was made from 1000 nucleotides upstream the open reading frame to 300 nucleotides downstream. Thus the open reading frame protein-coding potential appears on frame #3.
Sequences
| Color | Nucleotide sequence and Coding sequence | Predicted translation product |
| RED | start and stop codons | Initial methionine and sequence end |
| BLUE | coding sequence | protein sequence |
| grey | non-coding sequence (upstream, downstream or intron) | |
| grey | donor and acceptor splicing sites |
URL: http://www.genolevures.org/elt/SACE/SACE0B00440p