DEHA2B11572p_blastp.html
BLASTP 2.2.18 [Mar-02-2008]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for compositional score matrix adjustment: Altschul, Stephen F.,
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.
Query= DEHA2B11572p (infer) YOL093W TRM10 tRNA methyltransferase :
similar to uniprot|Q12400 Saccharomyces cerevisiae [Debaryomyces
hansenii CBS767]
(389 letters)
Database: Genolevures3.aa
48,939 sequences; 23,992,848 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
|DEHA2B11572p (infer) YOL093W TRM10 tRNA methyltransferase : simi... 803 0.0
|SAKL0C09834p (infer) YOL093W : similar to uniprot|Q12400 Sacchar... 248 1e-65
|CAGL0I07667p (infer) YOL093w : similar to uniprot|Q12400 Sacchar... 241 2e-63
|SACE0O01716p tRNA methyltransferase, methylates the N-1 position... 240 3e-63
|KLTH0C09922p (infer) YOL093W : similar to uniprot|Q12400 Sacchar... 238 9e-63
|KLLA0C03740p (infer) YOL093W : similar to uniprot|Q12400 Sacchar... 234 1e-61
|ZYRO0B06226p (infer) YOL093W : similar to uniprot|Q12400 Sacchar... 234 1e-61
|ERGO0D11880p Syntenic homolog of Saccharomyces cerevisiae YOL093... 228 1e-59
|YALI0F12771p some similarities with uniprot|Q12400 Saccharomyces... 206 4e-53
>|DEHA2B11572p (infer) YOL093W TRM10 tRNA methyltransferase : similar to
uniprot|Q12400 Saccharomyces cerevisiae [Debaryomyces
hansenii CBS767]
Length = 389
Score = 803 bits (2073), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 389/389 (100%), Positives = 389/389 (100%)
Query: 1 MNYNVDAIDSQMADNNVDIVQADAIISKEMENQDTEQSQKRSGSEVEKDDFKRQKVVVPE 60
MNYNVDAIDSQMADNNVDIVQADAIISKEMENQDTEQSQKRSGSEVEKDDFKRQKVVVPE
Sbjct: 1 MNYNVDAIDSQMADNNVDIVQADAIISKEMENQDTEQSQKRSGSEVEKDDFKRQKVVVPE 60
Query: 61 GMTKREYKRQLKQQRWEETKDEYKQKKREKKKAARERRKERIKEAEANGETNEELYNYHQ 120
GMTKREYKRQLKQQRWEETKDEYKQKKREKKKAARERRKERIKEAEANGETNEELYNYHQ
Sbjct: 61 GMTKREYKRQLKQQRWEETKDEYKQKKREKKKAARERRKERIKEAEANGETNEELYNYHQ 120
Query: 121 MKRAKVAPQEQIDTDVKIIMDCEFDSLMNDKEIVSLSNQITRSYSAKKHSTYDVQLDITS 180
MKRAKVAPQEQIDTDVKIIMDCEFDSLMNDKEIVSLSNQITRSYSAKKHSTYDVQLDITS
Sbjct: 121 MKRAKVAPQEQIDTDVKIIMDCEFDSLMNDKEIVSLSNQITRSYSAKKHSTYDVQLDITS 180
Query: 181 FNKNLKKRFEKAIPQYDKWTNVTFVENDKLEDILPMDDKQALSKYVYLTADTDEVIDTLE 240
FNKNLKKRFEKAIPQYDKWTNVTFVENDKLEDILPMDDKQALSKYVYLTADTDEVIDTLE
Sbjct: 181 FNKNLKKRFEKAIPQYDKWTNVTFVENDKLEDILPMDDKQALSKYVYLTADTDEVIDTLE 240
Query: 241 PHHTYIIGGIVDKNRYKNLCLNKAQSLGLKIGRLPIDKFIKMNGRQVLATSHVFELCCKW 300
PHHTYIIGGIVDKNRYKNLCLNKAQSLGLKIGRLPIDKFIKMNGRQVLATSHVFELCCKW
Sbjct: 241 PHHTYIIGGIVDKNRYKNLCLNKAQSLGLKIGRLPIDKFIKMNGRQVLATSHVFELCCKW 300
Query: 301 FENDKDWGKAFNEVLPPRKVKGKLTHGSDPEKSIEPSEVSEQPVSSEQSEQPVLSEQPVS 360
FENDKDWGKAFNEVLPPRKVKGKLTHGSDPEKSIEPSEVSEQPVSSEQSEQPVLSEQPVS
Sbjct: 301 FENDKDWGKAFNEVLPPRKVKGKLTHGSDPEKSIEPSEVSEQPVSSEQSEQPVLSEQPVS 360
Query: 361 SEQPVLSEQPVLSESSDEPSDEPSKGADH 389
SEQPVLSEQPVLSESSDEPSDEPSKGADH
Sbjct: 361 SEQPVLSEQPVLSESSDEPSDEPSKGADH 389
>|SAKL0C09834p (infer) YOL093W : similar to uniprot|Q12400 Saccharomyces
cerevisiae [Lachancea kluyveri]
Length = 303
Score = 248 bits (632), Expect = 1e-65, Method: Compositional matrix adjust.
Identities = 136/297 (45%), Positives = 193/297 (64%), Gaps = 21/297 (7%)
Query: 28 KEMENQDTEQSQKRSGSEVEKDDFKRQKVV--VPEGMTKREYKRQLKQQRWEETKDEYKQ 85
+ +E+ DT S G V + + +RQ + VPEGM+K ++K+ ++QR+EETK ++
Sbjct: 4 RRIESTDTSTSM---GEPVAEKEVQRQPPLPPVPEGMSKSQWKKLCRKQRFEETKAQFAA 60
Query: 86 KKREKKKAARERRKERIKEAEANGETNEELYNYHQMKRAKVAPQEQIDTDVKIIMDCEFD 145
++EK+K ARE ++ +I+E GE E ++KR QEQ D+ V I+MDC FD
Sbjct: 61 IRKEKRKKARENKRSKIQEFLDRGEEVPE-----ELKRKPRVNQEQRDSGVSIVMDCAFD 115
Query: 146 SLMNDKEIVSLSNQITRSYSAKKHSTYDVQLDITSFNKNLKKRFEKAIPQ--YDKWTNVT 203
LMNDKEIVS+S QITR+YS K + ++ + SF K LK RF+ + Y +W N
Sbjct: 116 DLMNDKEIVSMSTQITRAYSCNKRERHYAKIKVASFGKRLKARFDNGLSNCGYQQWKNFE 175
Query: 204 FVENDKLEDILPMDDKQALSKYVYLTADTDEVIDTLEPHHTYIIGGIVDKNRYKNLCLNK 263
F E+ P D +SK VYLTADTDE +++LEP TYI+GGIVDKNR+K LC NK
Sbjct: 176 FTA----EEGFPED----MSKVVYLTADTDEKLESLEPGMTYIVGGIVDKNRHKCLCYNK 227
Query: 264 AQSLGLKIGRLPIDKFIKMNGRQVLATSHVFELCCKWFENDKDWGKAFNEVLPPRKV 320
A+ LG+ RLPID++IK++GR+VL T+HV +L K+F+N +DW +AF VLP RK+
Sbjct: 228 AKELGIPTRRLPIDEYIKLSGRKVLTTTHVIQLMLKYFDN-RDWKEAFESVLPQRKL 283
>|CAGL0I07667p (infer) YOL093w : similar to uniprot|Q12400 Saccharomyces
cerevisiae [Candida glabrata CBS 138]
Length = 287
Score = 241 bits (614), Expect = 2e-63, Method: Compositional matrix adjust.
Identities = 127/265 (47%), Positives = 184/265 (69%), Gaps = 14/265 (5%)
Query: 58 VPEGMTKREYKRQLKQQRWEETKDEYKQKKREKKKAARERRKERIKEAEANGETNEELYN 117
VPEGM+K ++K+Q ++Q +E K+EY + ++EK+K A+E R+++I+E GE
Sbjct: 18 VPEGMSKSQWKKQWRRQMYEAKKEEYAEVRKEKRKRAKENRRKKIQEYIDRGEEVP---- 73
Query: 118 YHQMKRAKVAPQEQIDTDVKIIMDCEFDSLMNDKEIVSLSNQITRSYSAKKHSTYDVQLD 177
++KR ++Q+ + + II+DC FD LMNDKEIVS SNQITR+YSA + ++ +
Sbjct: 74 -AELKREPRVNRDQVASGINIILDCAFDDLMNDKEIVSTSNQITRAYSANRRASQYANIT 132
Query: 178 ITSFNKNLKKRFEKAI--PQYDKWTNVTFVENDKLEDILPMDDKQALSKYVYLTADTDEV 235
+TSFNK LK+RF+KA+ Y +W N FV ++KL + DK SK VYLTADT+E
Sbjct: 133 VTSFNKRLKERFDKALDDCNYPQWQNFKFVSDEKL---ITEGDK---SKMVYLTADTEEQ 186
Query: 236 IDTLEPHHTYIIGGIVDKNRYKNLCLNKAQSLGLKIGRLPIDKFIKMNGRQVLATSHVFE 295
+DTLEP TYI+GGIVDKNR+K LC NKA+ LG+ RLPI ++IK+ GR+VL T+HV +
Sbjct: 187 LDTLEPGMTYIVGGIVDKNRHKLLCYNKAKELGIPTRRLPIGEYIKIEGRKVLTTTHVIQ 246
Query: 296 LCCKWFENDKDWGKAFNEVLPPRKV 320
L K+ E+ +DW ++F V+P RK+
Sbjct: 247 LMLKYCES-RDWKESFESVIPSRKL 270
>|SACE0O01716p tRNA methyltransferase, methylates the N-1 position of guanosine in
tRNAs [Saccharomyces cerevisiae]
Length = 293
Score = 240 bits (612), Expect = 3e-63, Method: Compositional matrix adjust.
Identities = 124/273 (45%), Positives = 177/273 (64%), Gaps = 11/273 (4%)
Query: 58 VPEGMTKREYKRQLKQQRWEETKDEYKQKKREKKKAARERRKERIKEAEANGETNEELYN 117
VPEGM+K+++K+ K+QRWEE K +Y ++R KKK R R +I+E GE +
Sbjct: 22 VPEGMSKKQWKKMCKRQRWEENKAKYNAERRVKKKRLRHERSAKIQEYIDRGEEVPQ--- 78
Query: 118 YHQMKRAKVAPQEQIDTDVKIIMDCEFDSLMNDKEIVSLSNQITRSYSAKKHSTYDVQLD 177
++ R Q D+ ++II+DC FD LMNDKEIVSLSNQ+TR+YSA + + + ++
Sbjct: 79 --ELIREPRINVNQTDSGIEIILDCSFDELMNDKEIVSLSNQVTRAYSANRRANHFAEIK 136
Query: 178 ITSFNKNLKKRFEKAI--PQYDKWTNVTFVENDKLEDILPMDDKQALSKYVYLTADTDEV 235
+ F+K LK+RFE + Y+ W + F+ +DK I+ D+ + K VYLTADT+E
Sbjct: 137 VAPFDKRLKQRFETTLKNTNYENWNHFKFLPDDK---IMFGDEHISKDKIVYLTADTEEK 193
Query: 236 IDTLEPHHTYIIGGIVDKNRYKNLCLNKAQSLGLKIGRLPIDKFIKMNGRQVLATSHVFE 295
++ LEP YI+GGIVDKNRYK LCL KAQ +G+ RLPID++I + GR+VL T+HV +
Sbjct: 194 LEKLEPGMRYIVGGIVDKNRYKELCLKKAQKMGIPTRRLPIDEYINLEGRRVLTTTHVVQ 253
Query: 296 LCCKWFENDKDWGKAFNEVLPPRKVKGKLTHGS 328
L K+F+ D +W AF VLPPRK+ + S
Sbjct: 254 LMLKYFD-DHNWKNAFESVLPPRKLDAEAKSAS 285
>|KLTH0C09922p (infer) YOL093W : similar to uniprot|Q12400 Saccharomyces
cerevisiae [Kluyveromyces thermotolerans]
Length = 302
Score = 238 bits (607), Expect = 9e-63, Method: Compositional matrix adjust.
Identities = 129/297 (43%), Positives = 187/297 (62%), Gaps = 18/297 (6%)
Query: 58 VPEGMTKREYKRQLKQQRWEETKDEYKQKKREKKKAARERRKERIKEAEANGETNEELYN 117
VPEGM+K ++K+ K++R+EETKDE+ + +REK++ A+E R+ +I+E GE E
Sbjct: 20 VPEGMSKSQWKKVWKKKRFEETKDEFAKIRREKRQKAKETRRAKIQEYLDRGEEVPE--- 76
Query: 118 YHQMKRAKVAPQEQIDTDVKIIMDCEFDSLMNDKEIVSLSNQITRSYSAKKHSTYDVQLD 177
++R Q+Q D+ + II+DC FD LMNDKE+VSLS QITR+YS K + ++
Sbjct: 77 --DLRRKPRKNQDQKDSGINIILDCAFDDLMNDKEVVSLSTQITRAYSHNKRENHFAKVK 134
Query: 178 ITSFNKNLKKRFEKAI--PQYDKWTNVTFVENDKLEDILPMDDKQALSKYVYLTADTDEV 235
+TSFNK L+ RFE+ + +D+W N F E+ LP ++ VYLTADTDE
Sbjct: 135 VTSFNKRLRTRFEEGLKDAHHDEWKNFEFTEDP----TLPTENS------VYLTADTDET 184
Query: 236 IDTLEPHHTYIIGGIVDKNRYKNLCLNKAQSLGLKIGRLPIDKFIKMNGRQVLATSHVFE 295
++ LEP YI+GGIVDKNR+K LC NKA+ LG+ +LP+ +FIK+ GR+VL +HV
Sbjct: 185 LEKLEPGTNYIVGGIVDKNRHKLLCYNKARELGIPTKKLPLAEFIKLTGREVLTCTHVIH 244
Query: 296 LCCKWFENDKDWGKAFNEVLPPRKVKGKLTHGSDPEKSIEPSEVSEQPVSSEQSEQP 352
L ++F+N DW +AF VLP RK++ K+ P S +P S+ E+P
Sbjct: 245 LMLRYFDN-LDWKEAFETVLPQRKLEEAEAAAEAAAKAQSPQAESSEPSSATSEEEP 300
>|KLLA0C03740p (infer) YOL093W : similar to uniprot|Q12400 Saccharomyces
cerevisiae [Kluyveromyces lactis NRRL Y-1140]
Length = 298
Score = 234 bits (598), Expect = 1e-61, Method: Compositional matrix adjust.
Identities = 122/264 (46%), Positives = 174/264 (65%), Gaps = 18/264 (6%)
Query: 59 PEGMTKREYKRQLKQQRWEETKDEYKQKKREKKKAARERRKERIKEAEANGETNEELYNY 118
PEG++K ++K+ +++R+EET+ EY Q ++EK+ A+ R+E++KE GE E
Sbjct: 36 PEGISKSQWKKICRKKRFEETRAEYAQIRKEKRNRAKLARREKLKEYTDRGEEIPE---- 91
Query: 119 HQMKRAKVAPQEQIDTDVKIIMDCEFDSLMNDKEIVSLSNQITRSYSAKKHSTYDVQLDI 178
++KR Q D+ + II+DC FD LMND+EIVSLS Q+TR+YS+ K ++ +
Sbjct: 92 -ELKRPPKVNLNQSDSGISIILDCSFDDLMNDREIVSLSTQVTRAYSSNKRENNYAKIKV 150
Query: 179 TSFNKNLKKRFEKAIPQ--YDKWTNVTFVENDKLEDILPMDDKQALSKYVYLTADTDEVI 236
TSF+K LK+RF+ + Y KW N F + LP ++ VYLTADT+E +
Sbjct: 151 TSFDKRLKQRFDNDLSNSNYTKWKNFEFTA----DPTLPTENA------VYLTADTEEKL 200
Query: 237 DTLEPHHTYIIGGIVDKNRYKNLCLNKAQSLGLKIGRLPIDKFIKMNGRQVLATSHVFEL 296
DTLEP TYI+GGIVDKNR+KNLC NKA+ L + RLPI +FI + GR+VL TSH+ +L
Sbjct: 201 DTLEPGTTYIVGGIVDKNRHKNLCYNKAKELNIPTKRLPIGEFINLAGRKVLTTSHMVQL 260
Query: 297 CCKWFENDKDWGKAFNEVLPPRKV 320
++F+N KDW +AF VLPPRK+
Sbjct: 261 MLRYFDN-KDWKEAFESVLPPRKL 283
>|ZYRO0B06226p (infer) YOL093W : similar to uniprot|Q12400 Saccharomyces
cerevisiae [Zygosaccharomyces rouxii]
Length = 296
Score = 234 bits (598), Expect = 1e-61, Method: Compositional matrix adjust.
Identities = 131/277 (47%), Positives = 188/277 (67%), Gaps = 15/277 (5%)
Query: 49 DDFKRQKVVVP---EGMTKREYKRQLKQQRWEETKDEYKQKKREKKKAARERRKERIKEA 105
+D+KR+ +P EGM+K ++K+ K+QR+ K+EY Q ++EK+K ARE R+ RI+E
Sbjct: 4 EDYKRKMTTLPPTPEGMSKSKWKKVWKKQRYNIMKEEYAQIRKEKRKRARENRRARIQEY 63
Query: 106 EANGETNEELYNYHQMKRAKVAPQEQIDTDVKIIMDCEFDSLMNDKEIVSLSNQITRSYS 165
GE + ++KR Q D+ V I++DC FD LMND+EIVS+SNQITR+YS
Sbjct: 64 IDRGEEIPK-----ELKRQPRENPNQKDSGVNIVLDCGFDDLMNDREIVSMSNQITRAYS 118
Query: 166 AKKHSTYDVQLDITSFNKNLKKRFEKAIP--QYDKWTNVTFVENDKLEDILPMDDKQALS 223
+ + + + +TSF K LK RF++ + Y++W N F E+D+L + P DK +
Sbjct: 119 SNRRENHFTHMKVTSFGKRLKNRFDEEMKGCHYEQWKNFEFHEDDQL-IMGPDVDK---T 174
Query: 224 KYVYLTADTDEVIDTLEPHHTYIIGGIVDKNRYKNLCLNKAQSLGLKIGRLPIDKFIKMN 283
K VYLTADTD+ ++TLEP TYI+GGIVDKNR+K LC NKA+ +G+ RLPID+FI ++
Sbjct: 175 KLVYLTADTDDKLETLEPGMTYIVGGIVDKNRHKALCYNKAKEMGVPAKRLPIDEFINIS 234
Query: 284 GRQVLATSHVFELCCKWFENDKDWGKAFNEVLPPRKV 320
GR+VL T+HV +L K+F+N DW +AF VLPPRK+
Sbjct: 235 GRKVLTTTHVVQLMLKYFDN-HDWKEAFEYVLPPRKL 270
>|ERGO0D11880p Syntenic homolog of Saccharomyces cerevisiae YOL093W [Eremothecium
gossypii]
Length = 296
Score = 228 bits (581), Expect = 1e-59, Method: Compositional matrix adjust.
Identities = 131/285 (45%), Positives = 184/285 (64%), Gaps = 22/285 (7%)
Query: 58 VPEGMTKREYKRQLKQQRWEETKDEYKQKKREKKKAARERRKERIKEA--EANGETNEEL 115
VPEGM+K ++K+Q K++++E K Y + ++EKK+ ARE+R+ER+++A E GE EEL
Sbjct: 23 VPEGMSKSQWKKQWKKEQFELNKPLYAKIRKEKKQKAREQRRERLQKALEENGGEIPEEL 82
Query: 116 YNYHQMKRAKVAPQEQIDTDVKIIMDCEFDSLMNDKEIVSLSNQITRSYSAKKHSTYDVQ 175
+R Q D+ +K+I+DC FD LMN+KEIVSLS QITR+YSA K +
Sbjct: 83 ------RRTPRVNVNQKDSGIKVIIDCAFDELMNEKEIVSLSTQITRAYSANKRENHFAD 136
Query: 176 LDITSFNKNLKKRFEKAI--PQYDKWTNVTFVENDKLEDILPMDDKQALSKYVYLTADTD 233
+ +TSFNK LK+RF+ + YD W + F + E LP + VYLTADTD
Sbjct: 137 VKVTSFNKRLKERFDCGLKGANYDAWKHFEFTD----ESALPTTNA------VYLTADTD 186
Query: 234 EVIDTLEPHHTYIIGGIVDKNRYKNLCLNKAQSLGLKIGRLPIDKFIKMNGRQVLATSHV 293
E ++TLEP TYI+GGIVDKNR+K LC NKA+ LG+ RLPI ++IK+ GR+VL T+HV
Sbjct: 187 ETLETLEPGTTYIVGGIVDKNRHKALCYNKAKELGIPTRRLPIGEYIKLCGRKVLTTTHV 246
Query: 294 FELCCKWFENDKDWGKAFNEVLPPRKVKGKLTHGSDPEKSIEPSE 338
++ ++F+N DW +AF VLP RK+ H + S P+E
Sbjct: 247 IQIMLRYFDN-HDWKEAFESVLPARKLAELADHAQESNSS-SPAE 289
>|YALI0F12771p some similarities with uniprot|Q12400 Saccharomyces cerevisiae
Chromosome XV reading frame ORF YOL093W [Yarrowia
lipolytica CLIB122]
Length = 371
Score = 206 bits (524), Expect = 4e-53, Method: Compositional matrix adjust.
Identities = 125/271 (46%), Positives = 169/271 (62%), Gaps = 18/271 (6%)
Query: 51 FKRQKVVVPEGMTKREYKRQLKQQRWEETKDEYKQKKREKKKAARERRKERIKEAEANGE 110
+ + V+PEGM+K E+K+ K+ WE KDE K+EKKKAAR+R++ I E
Sbjct: 45 YNTKTAVIPEGMSKNEWKKAQKKAIWESKKDEIAAVKKEKKKAARKRKQLAISRGEIPAP 104
Query: 111 TNEELYNYHQMKRAKVAPQEQIDTDVKIIMDCEFDSLMNDKEIVSLSNQITRSYSAKKHS 170
++ + PQ Q+ + I++DC FD +M KE VSLS Q+ R YSA + +
Sbjct: 105 IPQD----------ERPPQTQLP--ISIVLDCGFDEMMTQKEKVSLSAQVGRCYSANRKA 152
Query: 171 TYDVQLDITSFNKNLKKRFEKAIPQ-YDKWTNVTFVENDKLEDILPMDDKQALSKYVYLT 229
L + SFNK LK RF + + ++ WTN+ FVE+D +P +D+ A SK VYL+
Sbjct: 153 DARFDLTVNSFNKGLKDRFNNEMNKVHELWTNIKFVEDDY---TVP-EDETAKSKLVYLS 208
Query: 230 ADTDEVIDTLEPHHTYIIGGIVDKNRYKNLCLNKAQSLGLKIGRLPIDKFIKMNGRQVLA 289
+D+D VI+ LE TYIIGGIVDK RYKNLC +KA GL+ GRLPI FIK++GR+VL
Sbjct: 209 SDSDNVINELEDGKTYIIGGIVDKGRYKNLCQDKASKQGLQTGRLPIADFIKLSGRKVLT 268
Query: 290 TSHVFELCCKWFENDKDWGKAFNEVLPPRKV 320
T+HVFE+ KW E KDW AF VLP RK+
Sbjct: 269 TNHVFEILLKWTEL-KDWKAAFEAVLPMRKL 298
BLASTP 2.2.18 [Mar-02-2008]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for compositional score matrix adjustment: Altschul, Stephen F.,
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.