DEHA2B05478p_blastp.html
BLASTP 2.2.18 [Mar-02-2008]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for compositional score matrix adjustment: Altschul, Stephen F.,
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.
Query= DEHA2B05478p (infer) YDR232w HEM1 5-aminolevulinate synthase :
similar to uniprot|P09950 Saccharomyces cerevisiae [Debaryomyces
hansenii CBS767]
(575 letters)
Database: Genolevures3.aa
48,939 sequences; 23,992,848 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
|DEHA2B05478p (infer) YDR232w HEM1 5-aminolevulinate synthase : s... 1196 0.0
|SAKL0H12364p highly similar to gnl|GLV|KLLA0C15059g Kluyveromyce... 748 0.0
|KLLA0C15059p uniprot|P78698 Kluyveromyces lactis KLLA0C15059g HE... 746 0.0
|ZYRO0A10032p highly similar to gnl|GLV|KLLA0C15059g Kluyveromyce... 733 0.0
|KLTH0E10538p (infer) YDR232W HEM1 5-aminolevulinate synthase cat... 727 0.0
|ERGO0B02486p Syntenic homolog of Saccharomyces cerevisiae YDR232... 701 0.0
|SACE0D10252p 5-aminolevulinate synthase, catalyzes the first ste... 692 0.0
|CAGL0B02607p (infer) YDR232w HEM1 : highly similar to uniprot|P0... 688 0.0
|YALI0C06083p (infer) 5- aminolevulinic acid synthase (HEM1p homo... 677 0.0
|YALI0F15345p (infer) YDR062w LCB2 serine C-palmitoyltransferase ... 149 7e-36
|KLTH0H07920p (infer) YDR062W LCB2 Component of serine palmitoylt... 137 4e-32
|ZYRO0G09152p (infer) YDR062W LCB2 Component of serine palmitoylt... 136 9e-32
|DEHA2F24926p (infer) LCB2 Serine palmitoyl Co-A transferase subu... 135 2e-31
|ERGO0G11220p Syntenic homolog of Saccharomyces cerevisiae YDR062... 131 2e-30
|SAKL0H19272p (infer) YDR062W LCB2 Component of serine palmitoylt... 126 8e-29
|SACE0D06688p Component of serine palmitoyltransferase, responsib... 126 9e-29
|KLLA0D02134p (infer) YDR062W LCB2 Component of serine palmitoylt... 123 8e-28
|CAGL0G05071p (infer) YDR062w LCB2 serine C-palmitoyltransferase ... 117 3e-26
|YALI0E17545p (infer) YDR232w HEM1 5-aminolevulinate synthase : w... 115 1e-25
|KLLA0A09955p (infer) YMR296C LCB1 Component of serine palmitoylt... 107 5e-23
|SAKL0H01144p (infer) cerevisiae LCB1 Component of serine palmito... 100 5e-21
|CAGL0G00440p (infer) YMR296c LCB1 serine C-palmitoyltransferase ... 98 3e-20
|SACE0M10164p Component of serine palmitoyltransferase, responsib... 98 3e-20
|YALI0C03179p (infer) Serine palmitoyl CoA transferase subunit LC... 94 4e-19
|ZYRO0D07282p (infer) cerevisiae LCB1 Component of serine palmito... 90 6e-18
|DEHA2E02134p (infer) YMR296C LCB1 Component of serine palmitoylt... 89 1e-17
|ERGO0B08624p Syntenic homolog of Saccharomyces cerevisiae YMR296... 83 1e-15
|KLTH0B09306p (infer) cerevisiae LCB1 Component of serine palmito... 74 5e-13
>|DEHA2B05478p (infer) YDR232w HEM1 5-aminolevulinate synthase : similar to
uniprot|P09950 Saccharomyces cerevisiae [Debaryomyces
hansenii CBS767]
Length = 575
Score = 1196 bits (3093), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 575/575 (100%), Positives = 575/575 (100%)
Query: 1 MESITRVSMSVCPFVKSSSAQALRQLSKNSALTSQARQCPFMGAALNAKESTRSYSSATK 60
MESITRVSMSVCPFVKSSSAQALRQLSKNSALTSQARQCPFMGAALNAKESTRSYSSATK
Sbjct: 1 MESITRVSMSVCPFVKSSSAQALRQLSKNSALTSQARQCPFMGAALNAKESTRSYSSATK 60
Query: 61 PVRATASSLASNPPSTMQSKYSFKAEELVGNKDAINLESKENTFDFKGYLNSELSKKRTD 120
PVRATASSLASNPPSTMQSKYSFKAEELVGNKDAINLESKENTFDFKGYLNSELSKKRTD
Sbjct: 61 PVRATASSLASNPPSTMQSKYSFKAEELVGNKDAINLESKENTFDFKGYLNSELSKKRTD 120
Query: 121 KSYRFFNNINRLANEFPKAHRSEENDKVTVWCSNDYLGMGKNENTINEMKRVLTKYGSGA 180
KSYRFFNNINRLANEFPKAHRSEENDKVTVWCSNDYLGMGKNENTINEMKRVLTKYGSGA
Sbjct: 121 KSYRFFNNINRLANEFPKAHRSEENDKVTVWCSNDYLGMGKNENTINEMKRVLTKYGSGA 180
Query: 181 GGTRNIAGHNIHALKLESELAALHKHEAALVFSSCFVANDAVLSLFGQKIKDLVIFSDEL 240
GGTRNIAGHNIHALKLESELAALHKHEAALVFSSCFVANDAVLSLFGQKIKDLVIFSDEL
Sbjct: 181 GGTRNIAGHNIHALKLESELAALHKHEAALVFSSCFVANDAVLSLFGQKIKDLVIFSDEL 240
Query: 241 NHASMIQGIRNSRAKKQVFKHNDLADLEEKLAQYPKSTPKLIAFESVYSMCGSIAPIEAI 300
NHASMIQGIRNSRAKKQVFKHNDLADLEEKLAQYPKSTPKLIAFESVYSMCGSIAPIEAI
Sbjct: 241 NHASMIQGIRNSRAKKQVFKHNDLADLEEKLAQYPKSTPKLIAFESVYSMCGSIAPIEAI 300
Query: 301 CDLAEKYGALTFLDEVHAVGMYGPHGAGVAEHLDFDAHLKSGIASPQTQTVMNRVDMVTG 360
CDLAEKYGALTFLDEVHAVGMYGPHGAGVAEHLDFDAHLKSGIASPQTQTVMNRVDMVTG
Sbjct: 301 CDLAEKYGALTFLDEVHAVGMYGPHGAGVAEHLDFDAHLKSGIASPQTQTVMNRVDMVTG 360
Query: 361 TLGKAYGTVGGYITGKANLIDWFRSFAPGFIFTTTLPPSIMAGSSASIRYQRSTLQDRIA 420
TLGKAYGTVGGYITGKANLIDWFRSFAPGFIFTTTLPPSIMAGSSASIRYQRSTLQDRIA
Sbjct: 361 TLGKAYGTVGGYITGKANLIDWFRSFAPGFIFTTTLPPSIMAGSSASIRYQRSTLQDRIA 420
Query: 421 QQTNTRYVKNNLTDIGIPVIPNPSHIVPVLVGNALDAKKASDLLLDKYNIYVQAINFPTV 480
QQTNTRYVKNNLTDIGIPVIPNPSHIVPVLVGNALDAKKASDLLLDKYNIYVQAINFPTV
Sbjct: 421 QQTNTRYVKNNLTDIGIPVIPNPSHIVPVLVGNALDAKKASDLLLDKYNIYVQAINFPTV 480
Query: 481 PIGQERLRITPTPGHGPELSNQLIGALDSVFNELSLSRIGDWEGKGGLCGVGEPDIEPIE 540
PIGQERLRITPTPGHGPELSNQLIGALDSVFNELSLSRIGDWEGKGGLCGVGEPDIEPIE
Sbjct: 481 PIGQERLRITPTPGHGPELSNQLIGALDSVFNELSLSRIGDWEGKGGLCGVGEPDIEPIE 540
Query: 541 HIWTSEQLALTDADINPNVIDPVIQPIGVSSGVRD 575
HIWTSEQLALTDADINPNVIDPVIQPIGVSSGVRD
Sbjct: 541 HIWTSEQLALTDADINPNVIDPVIQPIGVSSGVRD 575
>|SAKL0H12364p highly similar to gnl|GLV|KLLA0C15059g Kluyveromyces lactis
KLLA0C15059g and similar to YDR232W uniprot|P09950
Saccharomyces cerevisiae YDR232W HEM1 5- aminolevulinate
synthase catalyzes the first step in the heme
biosynthetic pathway an N-terminal signal sequence is
required for localization to the mitochondrial matrix
expression is regulated by Hap2p-Hap3p [Lachancea
kluyveri]
Length = 554
Score = 748 bits (1931), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 361/576 (62%), Positives = 446/576 (77%), Gaps = 25/576 (4%)
Query: 1 MESITRVSMSVCPFVKS--SSAQALRQLSKNSALTSQARQCPFMGAALNAKESTRSYSSA 58
MESI R S +CPFV S SS Q+++ L +++ L + A++CPFMG A+ + ++ + S++
Sbjct: 1 MESIARQSAKLCPFVHSAASSLQSVKAL-QHANLPAMAKKCPFMGKAM--QTASYATSTS 57
Query: 59 TKPVRATASSLASNPPSTMQSKYSFKAEELVGNKDAINLESKENTFDFKGYLNSELSKKR 118
T PV SS T +S + ++ ++E++FD+ G EL+KKR
Sbjct: 58 TAPVAQPVSS-------TKESAF-------------VDHATQESSFDYDGMFEHELNKKR 97
Query: 119 TDKSYRFFNNINRLANEFPKAHRSEENDKVTVWCSNDYLGMGKNENTINEMKRVLTKYGS 178
DKSYRFFNNINRLA EFP AHR ENDKVTVWCSNDYL + KN+ ++ MK+ L KYG+
Sbjct: 98 ADKSYRFFNNINRLAKEFPLAHRQLENDKVTVWCSNDYLVLSKNQQVVDVMKKTLDKYGA 157
Query: 179 GAGGTRNIAGHNIHALKLESELAALHKHEAALVFSSCFVANDAVLSLFGQKIKDLVIFSD 238
GAGGTRNIAGHN H + LE+E+AALHK E ALVFSSCFVANDAV+SL GQKIKDLVIFSD
Sbjct: 158 GAGGTRNIAGHNKHTMNLEAEIAALHKKEGALVFSSCFVANDAVISLLGQKIKDLVIFSD 217
Query: 239 ELNHASMIQGIRNSRAKKQVFKHNDLADLEEKLAQYPKSTPKLIAFESVYSMCGSIAPIE 298
ELNHASMI GI+++ K +FKHN+L LEE LA YPKSTPKLIAFESVYSM GS+A IE
Sbjct: 218 ELNHASMIVGIKHASTTKHIFKHNNLEQLEEMLAMYPKSTPKLIAFESVYSMSGSVADIE 277
Query: 299 AICDLAEKYGALTFLDEVHAVGMYGPHGAGVAEHLDFDAHLKSGIASPQTQTVMNRVDMV 358
ICDLAEKYGALTFLDEVHAVG+YGPHGAGVAEH DF+ H ++GIASP T+TVM+RVDM+
Sbjct: 278 KICDLAEKYGALTFLDEVHAVGLYGPHGAGVAEHCDFEDHRQAGIASPNTRTVMDRVDMI 337
Query: 359 TGTLGKAYGTVGGYITGKANLIDWFRSFAPGFIFTTTLPPSIMAGSSASIRYQRSTLQDR 418
TGTLGK++GTVGGY+ NLIDW RS++PGFIFTT+LPP++MAGS+ +IRYQRS L R
Sbjct: 338 TGTLGKSFGTVGGYVAASLNLIDWLRSYSPGFIFTTSLPPAVMAGSAEAIRYQRSHLNLR 397
Query: 419 IAQQTNTRYVKNNLTDIGIPVIPNPSHIVPVLVGNALDAKKASDLLLDKYNIYVQAINFP 478
QQ +T YVKN L D+GIPVIPNPSHIVPVL+GN AK+ASD+L+DK+ IYVQAINFP
Sbjct: 398 QDQQKHTAYVKNGLHDLGIPVIPNPSHIVPVLIGNPDLAKQASDILMDKHRIYVQAINFP 457
Query: 479 TVPIGQERLRITPTPGHGPELSNQLIGALDSVFNELSLSRIGDWEGKGGLCGVGEPDIEP 538
TV G ERLRITPTPGH +LS+ L+ A+D VFN L L R+ DWE +GGL GVG+PD P
Sbjct: 458 TVARGTERLRITPTPGHTNDLSDILLEAVDDVFNTLQLPRVKDWEMQGGLLGVGQPDYVP 517
Query: 539 IEHIWTSEQLALTDADINPNVIDPVIQPIGVSSGVR 574
++WT EQL+LT+ D++PNV +P+I + VSSG++
Sbjct: 518 EPNLWTEEQLSLTNEDLHPNVKEPIIDQLEVSSGIK 553
>|KLLA0C15059p uniprot|P78698 Kluyveromyces lactis KLLA0C15059g HEM1 5-
aminolevulinate synthase mitochondrial precursor
[Kluyveromyces lactis NRRL Y-1140]
Length = 570
Score = 746 bits (1925), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 366/576 (63%), Positives = 452/576 (78%), Gaps = 9/576 (1%)
Query: 1 MESITRVSMSVCPFVKSS--SAQALRQLSKNSALTSQARQCPFMGAALNAKESTRSYSSA 58
MES+ R S +CPF+ S+ S Q+++ L KN+ L + A+QCPFMG A+ E R Y+S+
Sbjct: 1 MESVIRSSAKICPFMHSATGSMQSVKAL-KNANLPAIAQQCPFMGKAM---EQRRGYASS 56
Query: 59 TKPVRATASSLASNPPSTMQSKYSFKAEELVGNKDAINLESKENTFDFKGYLNSELSKKR 118
A A++ A+ S S S +A + D ++ +KE +FD++G +S+L+KKR
Sbjct: 57 ASGASAAAAATATASTSASNSNSSVEAS---ASADVVDHATKEASFDYQGLFDSDLAKKR 113
Query: 119 TDKSYRFFNNINRLANEFPKAHRSEENDKVTVWCSNDYLGMGKNENTINEMKRVLTKYGS 178
DKSYRFFNNINRLA EFP AHR E+DKVTVWCSNDYL + KN+ I MK+ L KYG+
Sbjct: 114 MDKSYRFFNNINRLAKEFPMAHRKLEDDKVTVWCSNDYLALSKNQEVIEVMKKTLDKYGA 173
Query: 179 GAGGTRNIAGHNIHALKLESELAALHKHEAALVFSSCFVANDAVLSLFGQKIKDLVIFSD 238
GAGGTRNIAGHN HAL+LE+ELA LHK E ALVFSSCFVANDAV+SL GQKIKDLVIFSD
Sbjct: 174 GAGGTRNIAGHNKHALQLEAELATLHKKEGALVFSSCFVANDAVISLLGQKIKDLVIFSD 233
Query: 239 ELNHASMIQGIRNSRAKKQVFKHNDLADLEEKLAQYPKSTPKLIAFESVYSMCGSIAPIE 298
ELNHASMI GI+++ KK +FKHN+L LEE LA YPKSTPKLIAFESVYSM GS+A I+
Sbjct: 234 ELNHASMIVGIKHASTKKHIFKHNNLDQLEELLAMYPKSTPKLIAFESVYSMSGSVADID 293
Query: 299 AICDLAEKYGALTFLDEVHAVGMYGPHGAGVAEHLDFDAHLKSGIASPQTQTVMNRVDMV 358
ICDLAEKYGALTFLDEVHAVG+YGPHGAGVAEH +FDAH K+GIASP+ +TVM+RVDM+
Sbjct: 294 KICDLAEKYGALTFLDEVHAVGLYGPHGAGVAEHCNFDAHRKAGIASPEFRTVMDRVDMI 353
Query: 359 TGTLGKAYGTVGGYITGKANLIDWFRSFAPGFIFTTTLPPSIMAGSSASIRYQRSTLQDR 418
TGTLGK++GTVGGY+ G LIDW RS+APGFIFTTTLPP++MAG++ +IRYQRS L R
Sbjct: 354 TGTLGKSFGTVGGYVAGSLQLIDWVRSYAPGFIFTTTLPPAVMAGAAEAIRYQRSHLDLR 413
Query: 419 IAQQTNTRYVKNNLTDIGIPVIPNPSHIVPVLVGNALDAKKASDLLLDKYNIYVQAINFP 478
QQ +T YVK+ L D+GIPV+PNPSHIVPVLVGN AK+ASD+L+DK+ IYVQAINFP
Sbjct: 414 QDQQRHTTYVKDGLADLGIPVMPNPSHIVPVLVGNPHLAKQASDILMDKHRIYVQAINFP 473
Query: 479 TVPIGQERLRITPTPGHGPELSNQLIGALDSVFNELSLSRIGDWEGKGGLCGVGEPDIEP 538
TV G ERLRITPTPGH +LS+ L+ AL+ V++ L L R+ DWE +GGL GVG+P+ P
Sbjct: 474 TVARGTERLRITPTPGHTNDLSDILMDALEDVWSTLQLPRVRDWEAQGGLLGVGDPNHVP 533
Query: 539 IEHIWTSEQLALTDADINPNVIDPVIQPIGVSSGVR 574
++WT +QL LT+ D++PNV P+I+ + VSSG+R
Sbjct: 534 QPNLWTKDQLTLTNNDLHPNVKQPIIEQLEVSSGIR 569
>|ZYRO0A10032p highly similar to gnl|GLV|KLLA0C15059g Kluyveromyces lactis
KLLA0C15059g and similar to YDR232W uniprot|P09950
Saccharomyces cerevisiae YDR232W HEM1 5- aminolevulinate
synthase catalyzes the first step in the heme
biosynthetic pathway an N-terminal signal sequence is
required for localization to the mitochondrial matrix
expression is regulated by Hap2p-Hap3p
[Zygosaccharomyces rouxii]
Length = 557
Score = 733 bits (1893), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 352/576 (61%), Positives = 439/576 (76%), Gaps = 22/576 (3%)
Query: 1 MESITRVSMSVCPFV-KSSSAQALRQLSKNSALTSQARQCPFMGAALNAKESTRSYSSAT 59
MESI R S+ +CPF+ ++ SA+ L+ L NS L + ARQCP +G A+ R+Y++AT
Sbjct: 1 MESIARQSVKMCPFMQRAGSAKGLKAL-HNSNLPAAARQCPIVGHAMK-----RTYATAT 54
Query: 60 KPVRATASSLASNPPSTMQSKYSFKAEELVGNKDAINLESKENTFDFKGYLNSELSKKRT 119
R ++S +K + A E+V N ++E+TFD+ G SE+ KKR
Sbjct: 55 GAPREASAS---------NAKAARNANEVVANH-----ATQESTFDYNGLFESEIDKKRV 100
Query: 120 DKSYRFFNNINRLANEFPKAHRSEENDKVTVWCSNDYLGMGKNENTINEMKRVLTKYGSG 179
DKSYRFFNNINRLA EFPKAHR E DKVTVWCSNDYL + KN+ ++ MK+ L +YG+G
Sbjct: 101 DKSYRFFNNINRLAKEFPKAHRDVEEDKVTVWCSNDYLALSKNQQVVDAMKKTLDRYGAG 160
Query: 180 AGGTRNIAGHNIHALKLESELAALHKHEAALVFSSCFVANDAVLSLFGQKIKDLVIFSDE 239
AGGTRNIAGHN HAL+LE+E+AALHK E ALVFSSC+VANDAVLSL GQK+KDLVIFSDE
Sbjct: 161 AGGTRNIAGHNRHALRLEAEIAALHKKEGALVFSSCYVANDAVLSLLGQKVKDLVIFSDE 220
Query: 240 LNHASMIQGIRNSRAKKQVFKHNDLADLEEKLAQYPKSTPKLIAFESVYSMCGSIAPIEA 299
LNHASMI G+++++ K +F+HN+ A LEE L YPKSTPKLIAFESVYSM GS+A I+
Sbjct: 221 LNHASMIMGMKHAQTTKHIFRHNNYAHLEELLQMYPKSTPKLIAFESVYSMAGSVADIDK 280
Query: 300 ICDLAEKYGALTFLDEVHAVGMYGPHGAGVAEHLDFDAHLKSGIAS-PQTQTVMNRVDMV 358
IC LAEKYGALTFLDEVHAVG+YGPHGAGVAEH DF+ H +G+ S P TVM+RVDM+
Sbjct: 281 ICSLAEKYGALTFLDEVHAVGLYGPHGAGVAEHCDFEPHRVTGVESVPGNSTVMDRVDMI 340
Query: 359 TGTLGKAYGTVGGYITGKANLIDWFRSFAPGFIFTTTLPPSIMAGSSASIRYQRSTLQDR 418
TGTLGK++GTVGGY+ L+DW RS+APGFIFTT+LPPS+MAG++ +IRYQRS L+ R
Sbjct: 341 TGTLGKSFGTVGGYVAASQRLVDWLRSYAPGFIFTTSLPPSVMAGATEAIRYQRSHLELR 400
Query: 419 IAQQTNTRYVKNNLTDIGIPVIPNPSHIVPVLVGNALDAKKASDLLLDKYNIYVQAINFP 478
QQ +T YVK + ++GIPVIPNPSHIVPVLVGN AK+ASD+L+DK+ IYVQAINFP
Sbjct: 401 QLQQLHTGYVKQGMKELGIPVIPNPSHIVPVLVGNPDLAKQASDMLMDKHKIYVQAINFP 460
Query: 479 TVPIGQERLRITPTPGHGPELSNQLIGALDSVFNELSLSRIGDWEGKGGLCGVGEPDIEP 538
TV G ERLRITPTPGH +LS L+ A+D VF EL L R+ DWE +GG+ GVGEP
Sbjct: 461 TVSRGTERLRITPTPGHTDDLSEILLNAVDDVFKELQLPRVRDWESQGGILGVGEPGFVE 520
Query: 539 IEHIWTSEQLALTDADINPNVIDPVIQPIGVSSGVR 574
++WT EQL+LT+ +NPNV+DP++ + VSSG++
Sbjct: 521 QSNLWTEEQLSLTNDHLNPNVLDPILDHLEVSSGIK 556
>|KLTH0E10538p (infer) YDR232W HEM1 5-aminolevulinate synthase catalyzes the first
step in the heme biosynthetic pathway an N-terminal
signal sequence is required for localization to the
mitochondrial matrix expression is regulated by Hap2p-
Hap3p : similar to uniprot|P09950 Saccharomyces
cerevisiae [Kluyveromyces thermotolerans]
Length = 563
Score = 727 bits (1876), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 351/576 (60%), Positives = 429/576 (74%), Gaps = 16/576 (2%)
Query: 1 MESITRVSMSVCPFVKSSSAQALR--QLSKNSALTSQARQCPFMGAALNAKESTRSYSSA 58
M+SI R S +CPFV S + +LR Q + +++ A++CPFMG A+ T S ++
Sbjct: 1 MDSIARQSAKLCPFV-SRATSSLRNVQTLQQGNISAMAQRCPFMGQAMQKAHLTTSAAAG 59
Query: 59 TKPVRATASSLASNPPSTMQSKYSFKAEELVGNKDAINLESKENTFDFKGYLNSELSKKR 118
A + S + +A ++E FD++G +L KKR
Sbjct: 60 AAAAAPAAQEASRAAGKDQSSVMADRA-------------TQEAKFDYEGLFEQDLQKKR 106
Query: 119 TDKSYRFFNNINRLANEFPKAHRSEENDKVTVWCSNDYLGMGKNENTINEMKRVLTKYGS 178
DKSYRFFNNINRLA EFP AHR +E DKVTVWCSNDYL + KN+ ++ MKR L KYG+
Sbjct: 107 LDKSYRFFNNINRLAKEFPMAHRQQEEDKVTVWCSNDYLALSKNQQVVDVMKRTLDKYGA 166
Query: 179 GAGGTRNIAGHNIHALKLESELAALHKHEAALVFSSCFVANDAVLSLFGQKIKDLVIFSD 238
GAGGTRNIAGHN HAL+LE+E+AALHK E ALVFSSCFVANDAV+SL GQK+KDLVIFSD
Sbjct: 167 GAGGTRNIAGHNQHALRLEAEVAALHKKEGALVFSSCFVANDAVISLLGQKLKDLVIFSD 226
Query: 239 ELNHASMIQGIRNSRAKKQVFKHNDLADLEEKLAQYPKSTPKLIAFESVYSMCGSIAPIE 298
ELNHASMI GI+++ K +FKHNDL LEE LA YPKSTPKLIAFESVYSM GS+A I
Sbjct: 227 ELNHASMIVGIKHASTTKHIFKHNDLEHLEELLAMYPKSTPKLIAFESVYSMSGSVADIN 286
Query: 299 AICDLAEKYGALTFLDEVHAVGMYGPHGAGVAEHLDFDAHLKSGIASPQTQTVMNRVDMV 358
ICDLAEKYGALTFLDEVHAVG+YGPHGAGVAEH DF++H SGIASP QTVM+RVDM+
Sbjct: 287 KICDLAEKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRSSGIASPAHQTVMDRVDMI 346
Query: 359 TGTLGKAYGTVGGYITGKANLIDWFRSFAPGFIFTTTLPPSIMAGSSASIRYQRSTLQDR 418
TGTLGK++GTVGGY+ G LIDW RS+APGFIFTT+LPPS+MAG++ +IRYQRS L R
Sbjct: 347 TGTLGKSFGTVGGYVAGSLRLIDWLRSYAPGFIFTTSLPPSVMAGAAEAIRYQRSHLDLR 406
Query: 419 IAQQTNTRYVKNNLTDIGIPVIPNPSHIVPVLVGNALDAKKASDLLLDKYNIYVQAINFP 478
AQQ +T YVK L D+ IPVIPNPSHIVPVLVGN A++AS++L+DK+ IYVQAINFP
Sbjct: 407 QAQQRHTAYVKQGLADLDIPVIPNPSHIVPVLVGNPDLARQASEILMDKHRIYVQAINFP 466
Query: 479 TVPIGQERLRITPTPGHGPELSNQLIGALDSVFNELSLSRIGDWEGKGGLCGVGEPDIEP 538
TV G ERLRITPTPGH +LS+ L+ A+D VFN L L R+ DW+ +GGL GVG+ D
Sbjct: 467 TVARGTERLRITPTPGHTDDLSDILLDAVDDVFNTLQLPRVKDWKRQGGLLGVGQSDYMA 526
Query: 539 IEHIWTSEQLALTDADINPNVIDPVIQPIGVSSGVR 574
++WT +QL L++ D++PNV +P+I + VSSG+R
Sbjct: 527 EPNLWTEDQLQLSNDDLHPNVREPIIDQLEVSSGIR 562
>|ERGO0B02486p Syntenic homolog of Saccharomyces cerevisiae YDR232W (HEM1)
[Eremothecium gossypii]
Length = 556
Score = 701 bits (1808), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 340/576 (59%), Positives = 428/576 (74%), Gaps = 23/576 (3%)
Query: 1 MESITRVSMSVCPFVK--SSSAQALRQLSKNSALTSQARQCPFMGAALNAKESTRSYSSA 58
M+S+ R S +CPFV +SS Q ++ L K + +++ A+QCP M A+ A R Y +A
Sbjct: 1 MDSLARQSAKICPFVSRVTSSMQQVQVLHKTN-MSAMAQQCPVMRRAMAA----RGYVTA 55
Query: 59 TKPVRATASSLASNPPSTMQSKYSFKAEELVGNKDAINLESKENTFDFKGYLNSELSKKR 118
+ P A A+ + P T + ++E TFD+ G +EL KKR
Sbjct: 56 SPPAGAAAADVGEARPIT----------------PVLERGTQERTFDYDGLFETELQKKR 99
Query: 119 TDKSYRFFNNINRLANEFPKAHRSEENDKVTVWCSNDYLGMGKNENTINEMKRVLTKYGS 178
D SYRFFNNINRLA E+P AHR EE DKVTVWCSNDYL +NE + MKR + KYG+
Sbjct: 100 LDSSYRFFNNINRLAKEYPMAHRLEEEDKVTVWCSNDYLTYSRNEKVMETMKRTIDKYGA 159
Query: 179 GAGGTRNIAGHNIHALKLESELAALHKHEAALVFSSCFVANDAVLSLFGQKIKDLVIFSD 238
GAGGTRNIAGHN HA++LE+ELAALHK E ALVFSSCFVANDAVLSL GQK+ ++VIFSD
Sbjct: 160 GAGGTRNIAGHNRHAMRLEAELAALHKKEGALVFSSCFVANDAVLSLLGQKMPNMVIFSD 219
Query: 239 ELNHASMIQGIRNSRAKKQVFKHNDLADLEEKLAQYPKSTPKLIAFESVYSMCGSIAPIE 298
E+NHASMI GI+++ +K +F+HNDL LEE LA YPKS PKLIAFESVYSM GS+A I
Sbjct: 220 EMNHASMIMGIKHANVQKHIFRHNDLQHLEELLAMYPKSQPKLIAFESVYSMSGSVADIR 279
Query: 299 AICDLAEKYGALTFLDEVHAVGMYGPHGAGVAEHLDFDAHLKSGIASPQTQTVMNRVDMV 358
ICDLAEKYGALTFLDEVH+VG+YGPHGAGVAEHLDF+AH K+G+ASP TV++RVDM+
Sbjct: 280 KICDLAEKYGALTFLDEVHSVGLYGPHGAGVAEHLDFEAHRKAGLASPAQTTVLDRVDMI 339
Query: 359 TGTLGKAYGTVGGYITGKANLIDWFRSFAPGFIFTTTLPPSIMAGSSASIRYQRSTLQDR 418
T TLGK++G+VGGY+ L+D+ RS+APGFIFT++LPP++MAGS+A++ QRS+L R
Sbjct: 340 TATLGKSFGSVGGYLAASEKLVDFVRSYAPGFIFTSSLPPAVMAGSAAAVFDQRSSLHLR 399
Query: 419 IAQQTNTRYVKNNLTDIGIPVIPNPSHIVPVLVGNALDAKKASDLLLDKYNIYVQAINFP 478
QQ +T YVK L D+GIPV PNPSHIVPVLVGN AK+ASD+L++K+ IYVQAINFP
Sbjct: 400 QLQQKHTSYVKTGLGDLGIPVQPNPSHIVPVLVGNPDLAKRASDILMEKHRIYVQAINFP 459
Query: 479 TVPIGQERLRITPTPGHGPELSNQLIGALDSVFNELSLSRIGDWEGKGGLCGVGEPDIEP 538
TVP G ERLRITPTPGH +LS+ L+ A+D V+ L L R+ DW GGL GVGEPD P
Sbjct: 460 TVPRGTERLRITPTPGHTNDLSDVLLDAMDDVWKTLQLPRVSDWAAHGGLLGVGEPDYVP 519
Query: 539 IEHIWTSEQLALTDADINPNVIDPVIQPIGVSSGVR 574
++WT EQ++LT+ D++P+V PV + + VSSG++
Sbjct: 520 EANLWTEEQMSLTNDDLHPSVFSPVEKFLEVSSGIK 555
>|SACE0D10252p 5-aminolevulinate synthase, catalyzes the first step in the heme
biosynthetic pathway; an N-terminal signal sequence is
required for localization to the mitochondrial matrix;
expression is regulated by Hap2p-Hap3p [Saccharomyces
cerevisiae]
Length = 548
Score = 692 bits (1787), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 324/485 (66%), Positives = 392/485 (80%), Gaps = 6/485 (1%)
Query: 96 NLESKENTFDFKGYLNSELSKKRTDKSYRFFNNINRLANEFPKAHRSEENDKVTVWCSND 155
N ++E+ FD++G ++SEL KKR DKSYR+FNNINRLA EFP AHR E DKVTVWCSND
Sbjct: 63 NHSTQESGFDYEGLIDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCSND 122
Query: 156 YLGMGKNENTINEMKRVLTKYGSGAGGTRNIAGHNIHALKLESELAALHKHEAALVFSSC 215
YL + K+ ++ M + + KYG GAGGTRNIAGHNI L LE+ELA LHK E ALVFSSC
Sbjct: 123 YLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSC 182
Query: 216 FVANDAVLSLFGQKIKDLVIFSDELNHASMIQGIRNSRAKKQVFKHNDLADLEEKLAQYP 275
+VANDAVLSL GQK+KDLVIFSDELNHASMI GI+++ KK +FKHNDL +LE+ L YP
Sbjct: 183 YVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSYP 242
Query: 276 KSTPKLIAFESVYSMCGSIAPIEAICDLAEKYGALTFLDEVHAVGMYGPHGAGVAEHLDF 335
KS PKLIAFESVYSM GS+A IE ICDLA+KYGALTFLDEVHAVG+YGPHGAGVAEH DF
Sbjct: 243 KSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDF 302
Query: 336 DAHLKSGIASPQT------QTVMNRVDMVTGTLGKAYGTVGGYITGKANLIDWFRSFAPG 389
++H SGIA+P+T +TVM+RVDM+TGTLGK++G+VGGY+ LIDWFRSFAPG
Sbjct: 303 ESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPG 362
Query: 390 FIFTTTLPPSIMAGSSASIRYQRSTLQDRIAQQTNTRYVKNNLTDIGIPVIPNPSHIVPV 449
FIFTTTLPPS+MAG++A+IRYQR + R +QQ +T YVK ++GIPVIPNPSHIVPV
Sbjct: 363 FIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVIPNPSHIVPV 422
Query: 450 LVGNALDAKKASDLLLDKYNIYVQAINFPTVPIGQERLRITPTPGHGPELSNQLIGALDS 509
L+GNA AK+ASD+L++K+ IYVQAINFPTV G ERLRITPTPGH +LS+ LI A+D
Sbjct: 423 LIGNADLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILINAVDD 482
Query: 510 VFNELSLSRIGDWEGKGGLCGVGEPDIEPIEHIWTSEQLALTDADINPNVIDPVIQPIGV 569
VFNEL L R+ DWE +GGL GVGE ++WTS QL+LT+ D+NPNV DP+++ + V
Sbjct: 483 VFNELQLPRVRDWESQGGLLGVGESGFVEESNLWTSSQLSLTNDDLNPNVRDPIVKQLEV 542
Query: 570 SSGVR 574
SSG++
Sbjct: 543 SSGIK 547
>|CAGL0B02607p (infer) YDR232w HEM1 : highly similar to uniprot|P09950
Saccharomyces cerevisiae [Candida glabrata CBS 138]
Length = 530
Score = 688 bits (1776), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 323/482 (67%), Positives = 391/482 (81%), Gaps = 6/482 (1%)
Query: 99 SKENTFDFKGYLNSELSKKRTDKSYRFFNNINRLANEFPKAHRSEENDKVTVWCSNDYLG 158
++E FDF+G+ SEL+KKR DKSYR+FNNINRLA EFP AHR E+DKVTVWCSNDYL
Sbjct: 48 TQETPFDFEGHFESELAKKRLDKSYRYFNNINRLAKEFPLAHRQLEDDKVTVWCSNDYLA 107
Query: 159 MGKNENTINEMKRVLTKYGSGAGGTRNIAGHNIHALKLESELAALHKHEAALVFSSCFVA 218
+ KN ++ M++ + KYG+GAGGTRNIAGHNI ++LE+ELAALHK E ALVFSSC+VA
Sbjct: 108 LSKNPQVLDAMRKTIDKYGAGAGGTRNIAGHNIPTMRLEAELAALHKKEGALVFSSCYVA 167
Query: 219 NDAVLSLFGQKIKDLVIFSDELNHASMIQGIRNSRAKKQVFKHNDLADLEEKLAQYPKST 278
NDAV+SL GQK+KDLVIFSDELNHASMI GI+++ K +F+HNDLA LEE L YPKST
Sbjct: 168 NDAVISLLGQKVKDLVIFSDELNHASMIVGIKHANRPKHIFRHNDLAQLEEMLQMYPKST 227
Query: 279 PKLIAFESVYSMCGSIAPIEAICDLAEKYGALTFLDEVHAVGMYGPHGAGVAEHLDFDAH 338
PKLIAFESVYSM GS+A I ICDLAEKYGALTFLDEVHAVG+YGPHGAGVAEH DF+AH
Sbjct: 228 PKLIAFESVYSMAGSVADINKICDLAEKYGALTFLDEVHAVGLYGPHGAGVAEHCDFEAH 287
Query: 339 LKSGIASP------QTQTVMNRVDMVTGTLGKAYGTVGGYITGKANLIDWFRSFAPGFIF 392
+GIA+P + +TVM+RVDM+TGTLGK++GTVGGY+ + LIDW RS+APGFIF
Sbjct: 288 RVAGIATPPQGDNGRLRTVMDRVDMITGTLGKSFGTVGGYVAASSKLIDWVRSYAPGFIF 347
Query: 393 TTTLPPSIMAGSSASIRYQRSTLQDRIAQQTNTRYVKNNLTDIGIPVIPNPSHIVPVLVG 452
TTTLPP++MAG++ +IR+QRS L R QQ +T YVK L D+GIPVIPNPSHIVPVL+G
Sbjct: 348 TTTLPPAVMAGAAEAIRFQRSHLNLRQDQQRHTAYVKKGLHDLGIPVIPNPSHIVPVLIG 407
Query: 453 NALDAKKASDLLLDKYNIYVQAINFPTVPIGQERLRITPTPGHGPELSNQLIGALDSVFN 512
N AK+ASD+L++K+ IYVQAINFPTV G ERLRITPTPGH +LS+ LI A+D VFN
Sbjct: 408 NPDLAKQASDILMEKHRIYVQAINFPTVSRGTERLRITPTPGHTNDLSDILIAAVDDVFN 467
Query: 513 ELSLSRIGDWEGKGGLCGVGEPDIEPIEHIWTSEQLALTDADINPNVIDPVIQPIGVSSG 572
EL L RI DWE +GGL GVG+ + P ++WT EQL+ ++ D+N NV +PVI + VSSG
Sbjct: 468 ELQLPRIRDWEMQGGLLGVGDKNFVPEPNLWTEEQLSFSNEDLNSNVFEPVIDQLEVSSG 527
Query: 573 VR 574
V+
Sbjct: 528 VK 529
>|YALI0C06083p (infer) 5- aminolevulinic acid synthase (HEM1p homologue) : similar
to uniprot|Q9Y8A4 Aspergillus oryzae [Yarrowia
lipolytica CLIB122]
Length = 563
Score = 677 bits (1747), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 335/565 (59%), Positives = 416/565 (73%), Gaps = 22/565 (3%)
Query: 1 MESITRVSMSVCPFVKSSSAQALRQLSKNSALTSQARQCPFMGAAL-----------NAK 49
MES+ R S +CP++ +SA +L+QL N LT +A QCP MG A+ NA+
Sbjct: 1 MESLVRQSKKLCPYIGRTSASSLKQLG-NGRLTQKAGQCPIMGKAMGVRGFKSDAGSNAE 59
Query: 50 ESTRSYSSATKPVRAT---ASSLASNPPSTMQSKYSFKAEELVGNKDAINLESKENTFDF 106
+T +A + T A+ + PS+ Y F + K TF++
Sbjct: 60 SATVDVHAAVDTSKGTCPHAAQYSPVYPSSRLDNYPFGMTQRGLGKVPTQDAHNATTFNY 119
Query: 107 KGYLNSELSKKRTDKSYRFFNNINRLANEFPKAHR-SEENDKVTVWCSNDYLGMGKNENT 165
+ + ++++ K DKSYR+FNNINRLA EFP+AHR S E DKVTVWC+NDYLGMG+N
Sbjct: 120 ESFYENKINAKHQDKSYRYFNNINRLAAEFPRAHRGSIEEDKVTVWCANDYLGMGRNPVV 179
Query: 166 INEMKRVLTKYGSGAGGTRNIAGHNIHALKLESELAALHKHEAALVFSSCFVANDAVLSL 225
++ M L KYG+GAGGTRNIAGHN HA++LE+ +A LHK EAALVFSSC+VAND+ LSL
Sbjct: 180 VDAMHETLDKYGAGAGGTRNIAGHNRHAVELEAAIADLHKKEAALVFSSCYVANDSTLSL 239
Query: 226 FGQKIKDLVIFSDELNHASMIQGIRNSRAKKQVFKHNDLADLEEKLAQYPKSTPKLIAFE 285
GQ + + V FSD NHASMI GIR+ ++K V+KHNDLADLE KLA+YPKSTPK+IAFE
Sbjct: 240 LGQALPNCVYFSDASNHASMIHGIRHGGSEKVVWKHNDLADLEAKLARYPKSTPKVIAFE 299
Query: 286 SVYSMCGSIAPIEAICDLAEKYGALTFLDEVHAVGMYGPHGAGVAEHLDFDAHLKSGIAS 345
SVYSMCGSI PIE ICDLA+KYGA+TFLDEVHAVGMYGP GAGVAEHLDF+ H SG A
Sbjct: 300 SVYSMCGSIGPIEEICDLADKYGAITFLDEVHAVGMYGPTGAGVAEHLDFE-HYHSG-AQ 357
Query: 346 PQTQTVMNRVDMVTGTLGKAYGTVGGYITGKANLIDWFRSFAPGFIFTTTLPPSIMAGSS 405
Q Q +M+RVD+ TGTLGKAYG VGGYI G A +D RS+APGFIFTTTLPP+ MAG+
Sbjct: 358 TQRQPIMDRVDIFTGTLGKAYGCVGGYIAGSAKFVDMVRSYAPGFIFTTTLPPATMAGAR 417
Query: 406 ASIRYQRSTLQDRIAQQTNTRYVKNNLTDIGIPVIPNPSHIVPVLVGNALDAKKASDLLL 465
A+I YQ++T++DR+AQQT+TRYVK+ L + GIPV+PNPSHIVPVLVG+A AK ASDLLL
Sbjct: 418 AAINYQKATMKDRVAQQTHTRYVKDKLANRGIPVVPNPSHIVPVLVGDAQKAKAASDLLL 477
Query: 466 DKYNIYVQAINFPTVPIGQERLRITPTPGHGPELSNQLIGALDSVFNELSLSRIGDWEGK 525
K+ IYVQAINFPTVPIGQERLR+TPTPGH L ++L+ AL+ V+ EL L R+ DW +
Sbjct: 478 TKHQIYVQAINFPTVPIGQERLRVTPTPGHHEGLCDELVAALEDVWQELDLKRVEDWTAE 537
Query: 526 GGLCGVGEP-DIEPIEHIWTSEQLA 549
GGLCGVGE ++EP +W+ EQL+
Sbjct: 538 GGLCGVGEGVEVEP---LWSEEQLS 559
>|YALI0F15345p (infer) YDR062w LCB2 serine C-palmitoyltransferase subunit :
similar to uniprot|P40970 Saccharomyces cerevisiae
[Yarrowia lipolytica CLIB122]
Length = 541
Score = 149 bits (377), Expect = 7e-36, Method: Compositional matrix adjust.
Identities = 126/448 (28%), Positives = 204/448 (45%), Gaps = 54/448 (12%)
Query: 124 RFFNNINRLANEFPKAHR--SEENDKVTVWCSNDYLGMGKNENTINEMKRV-LTKYGSGA 180
R+ ++R++N++ ++ D + + S +YLG ++ + V + G +
Sbjct: 116 RYITVLDRVSNDYNTTYKYLGTSTDCLNL-SSYNYLGFAQSSGQCTDAAEVSINTEGISS 174
Query: 181 GGTRNIAGHNIHALKLESELAALHKHEAALVFSSCFVANDAVLSLFGQKIKDLVIFSDEL 240
GTR + G +K E +A E ALV+S + N +V S K ++ SD L
Sbjct: 175 FGTRAVCGTLDAHVKTEKRVAEFLGKEDALVYSMGYGTNASVFSSLVDK--HCLVLSDAL 232
Query: 241 NHASMIQGIRNSRAKKQVFKHNDLADLEEKL-AQYPKSTPK--------LIAFESVYSMC 291
NH S+ G R S A ++FKHND DLE L Q + PK L+A E +YSM
Sbjct: 233 NHGSIRYGARLSGAVIKIFKHNDTKDLERVLREQISQGQPKTHRPWKKILVAVEGLYSME 292
Query: 292 GSIAPIEAICDLAEKYGALTFLDEVHAVGMYGPHGAGVAEHLDFDAHLKSGIASPQTQTV 351
G++ + +CDL +KY F+DE H++G GP G G+ ++L D
Sbjct: 293 GTMTDLPTMCDLRDKYKFYLFVDEAHSIGALGPRGRGICDYLAVDP-------------- 338
Query: 352 MNRVDMVTGTLGKAYGTVGGYITGKANLIDWFRSFAPGFIFTTTLPPSIMAGSSASIRYQ 411
RVD++ GT K++G GGYI LI+ R G ++ ++ P ++A +A+++
Sbjct: 339 -ARVDILMGTFTKSFGATGGYIASSHELINHLRVNNMGNVYAESVSPPVLAQITAALQTI 397
Query: 412 RSTLQ--------DRIAQQTNTRYVKNNLTDIGIPVIP-NPSHIVPVLVGNALDAKKASD 462
++ +RIA N+RY++ L +G V + S I+PVL+ +
Sbjct: 398 DGEIRPGEGEERLERIA--FNSRYLRLALKRLGFIVYGIDDSPIIPVLLYVPAKMPEMGR 455
Query: 463 LLLDKYNIYVQAINFPTVPIGQERLRITPTPGHGPELSNQLIGALDSVFNELSLSRIGDW 522
+LL K I V + +P I R R + E +++I + + N LS
Sbjct: 456 ILL-KMGIAVVVVGYPATDIASSRARFCMSAALTKEDLDRIIKVMWQLGNILSFKY---- 510
Query: 523 EGKGGLCGVGEPDIE-PIEHIWTSEQLA 549
G G PD + H SE LA
Sbjct: 511 -------GKGMPDANGKVRHWELSEVLA 531
>|KLTH0H07920p (infer) YDR062W LCB2 Component of serine palmitoyltransferase
responsible along with Lcb1p for the first committed
step in sphingolipid synthesis which is the condensation
of serine with palmitoyl-CoA to form 3- ketosphinganine
: highly similar to uniprot|P40970 Saccharomyces
cerevisiae [Kluyveromyces thermotolerans]
Length = 562
Score = 137 bits (344), Expect = 4e-32, Method: Compositional matrix adjust.
Identities = 130/459 (28%), Positives = 207/459 (45%), Gaps = 55/459 (11%)
Query: 110 LNSELSKKRTDKSYRFFNNINRLANEFPKAHRSEENDKVTVWCSN----DYLGMGKNEN- 164
++ S+ T RF I+R++++ + + T C N +YLG ++E
Sbjct: 117 IDDCFSRPTTGVPGRFITCIDRISHDLNSYY---THPGTTTMCLNLSSYNYLGFAQSEGK 173
Query: 165 -TINEMKRVLTKYGSGAGGTRNIAGHNIHALKLESELAALHKHEAALVFSSCFVANDAVL 223
T N + V KYG AGG R AG + L+ E +A E A+VFS + N
Sbjct: 174 CTDNAIASV-DKYGLTAGGPRAQAGTSDLHLETEKLVARFVGKEDAMVFSMGYSTN---- 228
Query: 224 SLFGQKIKD--LVIFSDELNHASMIQGIRNSRAKKQVFKHNDLADLEEKLA-QYPKSTPK 280
+ F I D ++ SDELNH S+ G+R S + FKHND+ LE+ + Q + PK
Sbjct: 229 ANFFNSILDSKCLVISDELNHTSIRTGVRLSGTAVKAFKHNDMEALEKLIKEQIVQGQPK 288
Query: 281 --------LIAFESVYSMCGSIAPIEAICDLAEKYGALTFLDEVHAVGMYGPHGAGVAEH 332
LI E ++SM G++ + + +L KY F+DE H++G GP G GV ++
Sbjct: 289 THRPWKKILICVEGLFSMEGTMCNLPKLIELKNKYKCYLFVDEAHSIGAIGPQGRGVCDY 348
Query: 333 LDFDAHLKSGIASPQTQTVMNRVDMVTGTLGKAYGTVGGYITGKANLIDWFRSFAPGFIF 392
+ + VD++ GT K++G GGYI +ID R +
Sbjct: 349 FGINP---------------SEVDIMMGTFTKSFGAAGGYIAADKKVIDKLRCDLTIPNY 393
Query: 393 TTTLPPSIMAGSSASIRYQRSTLQ--------DRIAQQTNTRYVKNNLTDIGIPVIP-NP 443
++P I+A +SAS+R L RIA N+RY++ L +G V
Sbjct: 394 GESVPAPILAQTSASLRIITGELNPGEGLERLQRIA--FNSRYLRLALQRLGFIVYGIAD 451
Query: 444 SHIVPVLVGNALDAKKASDLLLDKYNIYVQAINFPTVPIGQERLRITPTPGHGPELSNQL 503
S +VP+L+ S ++L + I V + +P P+ + R+R + E + L
Sbjct: 452 SPVVPMLLYAPSKMPAFSRMMLQR-KIAVVVVAYPATPLIESRVRFCVSAALTKEDIDYL 510
Query: 504 IGALDSVFNELSLSRIGDWEGKGGLCGVGEPDIEPIEHI 542
+ ++ V +L L GK G G+P IE +
Sbjct: 511 LRHVNEVGEKLFLKV---STGKAGGSLDGKPPRWDIEEV 546
>|ZYRO0G09152p (infer) YDR062W LCB2 Component of serine palmitoyltransferase
responsible along with Lcb1p for the first committed
step in sphingolipid synthesis which is the condensation
of serine with palmitoyl-CoA to form 3- ketosphinganine
: highly similar to uniprot|P40970 Saccharomyces
cerevisiae [Zygosaccharomyces rouxii]
Length = 568
Score = 136 bits (342), Expect = 9e-32, Method: Compositional matrix adjust.
Identities = 117/402 (29%), Positives = 185/402 (46%), Gaps = 38/402 (9%)
Query: 107 KGYLNSELSKKRTDKSYRFFNNINRLANEFPKAHRSEENDKVTV-WCSNDYLGMGKNEN- 164
K ++ S+ T RF I+R+++E K + + S +YLG ++E
Sbjct: 120 KKKIDDCFSRPTTGVPGRFIRCIDRISHEENKYFTYPGTTSMCLNLSSYNYLGFAQSEGQ 179
Query: 165 -TINEMKRVLTKYGSGAGGTRNIAGHNIHALKLESELAALHKHEAALVFSSCFVANDAVL 223
T ++ V KYG +GG R G L E +A+ + A++FS + N
Sbjct: 180 CTTTALQSV-DKYGIHSGGPRTQIGTTDLHLDAERLIASFLGKQDAVIFSMGYGTNANFF 238
Query: 224 SLFGQKIKDLVIFSDELNHASMIQGIRNSRAKKQVFKHNDLADLEEKL-AQYPKSTPK-- 280
+ F K LVI SDELNHAS+ G+R S A + F HND+ LE+ + Q PK
Sbjct: 239 NAFLDS-KCLVI-SDELNHASIRTGVRLSGAAVRTFAHNDMVGLEKLIREQIVLGQPKTN 296
Query: 281 ------LIAFESVYSMCGSIAPIEAICDLAEKYGALTFLDEVHAVGMYGPHGAGVAEHLD 334
LI E +YSM G++ + + +L +KY F+DE H+VG GP G GV +
Sbjct: 297 RPWKKILICVEGLYSMEGTLCSLPEVVELKKKYKCYLFVDEAHSVGAMGPTGRGVCDLFG 356
Query: 335 FDAHLKSGIASPQTQTVMNRVDMVTGTLGKAYGTVGGYITGKANLIDWFRSFAPGFIFTT 394
D N VD + GTL K++G GGYI +ID R +
Sbjct: 357 VDP---------------NDVDFLMGTLTKSFGAAGGYIASNKWVIDRLRLDLTTSNYAE 401
Query: 395 TLPPSIMAGSSASIRYQRSTL-----QDRIAQ-QTNTRYVKNNLTDIGIPVIPNP-SHIV 447
P ++A AS++ + L ++R+ + N+RY++ L +G V P S ++
Sbjct: 402 PTPAPVLAQIIASLKTIKGELAPGEGKERLQRIAFNSRYLRLGLQRLGFIVYGAPDSPVI 461
Query: 448 PVLVGNALDAKKASDLLLDKYNIYVQAINFPTVPIGQERLRI 489
P+L+ S ++L + I V + +P P+ + R+R
Sbjct: 462 PLLLYCPTKMPAFSRMMLQR-KIAVVVVAYPATPLIESRVRF 502
>|DEHA2F24926p (infer) LCB2 Serine palmitoyl Co-A transferase subunit 2 : similar
to uniprot|Q9UVB9 Pichia ciferrii [Debaryomyces hansenii
CBS767]
Length = 557
Score = 135 bits (339), Expect = 2e-31, Method: Compositional matrix adjust.
Identities = 104/358 (29%), Positives = 171/358 (47%), Gaps = 41/358 (11%)
Query: 153 SNDYLGMGKNENTINEMK-RVLTKYGSGAGGTRNIAGHNIHALKLESELAALHKHEAALV 211
S +YLG +++ + + + YG+ R+++G + E +A E A++
Sbjct: 157 SYNYLGFAQSKGLCTDHALKAVEDYGTSGCSPRSLSGTTDLHKECERVIADFVYQEDAII 216
Query: 212 FSSCFVANDAVLSLFGQKIKDLVIFSDELNHASMIQGIRNSRAKKQVFKHNDLADLEEKL 271
S + N + + + +I SDELNHAS+ GIR S A +VFKHND+ DLE+ L
Sbjct: 217 VSQGYGTNANLFASLADA--NSLIISDELNHASIRFGIRLSGASVKVFKHNDMRDLEKLL 274
Query: 272 ----AQYPKSTPK-----LIAFESVYSMCGSIAPIEAICDLAEKYGALTFLDEVHAVGMY 322
AQ T + +IA E +YSM G++ + I +L EKY F+DE H++G
Sbjct: 275 RNSIAQGQPRTHRAWKKIIIAVEGLYSMEGNMCNLPQIVELKEKYKCYLFVDEAHSIGAL 334
Query: 323 GPHGAGVAEHLDFDAHLKSGIASPQTQTVMNRVDMVTGTLGKAYGTVGGYITGKANLIDW 382
GP G G+ ++ D+ R+D++ GT K++G GGYI G LI+
Sbjct: 335 GPEGRGICDYFSVDSR---------------RIDLLMGTFTKSFGATGGYIAGPKALINK 379
Query: 383 FRSFAPGFIFTTTLPPSIMAGSSASIRYQRSTLQ--------DRIAQQTNTRYVKNNLTD 434
R ++ +PP ++ +S+ +L RIA N+RY++ L
Sbjct: 380 LRINYITNNYSECVPPPVLGQIISSLSVIDGSLNPGEGSERLKRIA--FNSRYLRLGLKK 437
Query: 435 IGIPVI-PNPSHIVPVLVGNALDAKK-ASDLLLDKYNIYVQAINFPTVPIGQERLRIT 490
+G V + S ++P+L+ L K A L NI V +++P P+ R+R+
Sbjct: 438 LGFIVYGADDSPVIPLLL--FLPGKMPAVSRFLYSMNIAVVVVSYPATPLSSARVRLC 493
>|ERGO0G11220p Syntenic homolog of Saccharomyces cerevisiae YDR062W (LCB2)
[Eremothecium gossypii]
Length = 562
Score = 131 bits (330), Expect = 2e-30, Method: Compositional matrix adjust.
Identities = 122/456 (26%), Positives = 205/456 (44%), Gaps = 43/456 (9%)
Query: 107 KGYLNSELSKKRTDKSYRFFNNINRLANEFPKAHRSEENDKVTV-WCSNDYLGMGKNENT 165
K ++ S+ T RF I+R+A+ + + + S +YLG ++E
Sbjct: 114 KQRIDDCFSRPTTGVPGRFIRCIDRIAHSLNEYFTFPGTTSMCLNLSSYNYLGFAQSEGL 173
Query: 166 INEMK-RVLTKYGSGAGGTRNIAGHNIHALKLESELAALHKHEAALVFSSCFVANDAVLS 224
+ + +YG G+R +G ++ E +A E A++FS + N + +
Sbjct: 174 CTDAAVDSVHRYGINTHGSRMQSGTTDLHVEAERYVANFLGMEDAMIFSMGYGTNANLFN 233
Query: 225 LFGQKIKDLVIFSDELNHASMIQGIRNSRAKKQVFKHNDLADLEEKL-AQYPKSTPK--- 280
F K LVI SDELNH S+ G+R S A + FKHND+ LE+ + Q + PK
Sbjct: 234 SFLDN-KCLVI-SDELNHTSIRTGVRLSDAAVRTFKHNDMEALEKLIREQIIQGQPKTHR 291
Query: 281 -----LIAFESVYSMCGSIAPIEAICDLAEKYGALTFLDEVHAVGMYGPHGAGVAEHLDF 335
LI E +YSM G++ + + +L +KY ++DE H++G GPHG GV ++
Sbjct: 292 PWKKILICVEGLYSMEGTMCNLPKLIELKKKYKCYLYVDEAHSIGAMGPHGRGVCDYFGV 351
Query: 336 DAHLKSGIASPQTQTVMNRVDMVTGTLGKAYGTVGGYITGKANLIDWFRSFAPGFIFTTT 395
D VD++ GTL K++G GGY+ + +ID R +
Sbjct: 352 DP---------------TEVDILMGTLTKSFGAAGGYVAAQKWIIDRLRLDLTTSNYGEP 396
Query: 396 LPPSIMAGSSASIRYQRSTLQ--------DRIAQQTNTRYVKNNLTDIGIPVIP-NPSHI 446
P ++A +S+R L RIA N+RY++ L +G V S +
Sbjct: 397 SPAPVLAQIISSMRIIIGELNPGEGLERLQRIA--FNSRYLRLALQRLGFIVYGIADSPV 454
Query: 447 VPVLVGNALDAKKASDLLLDKYNIYVQAINFPTVPIGQERLRITPTPGHGPELSNQLIGA 506
+P+L+ + S ++L + I V + +P P+ + R+R + E + L+
Sbjct: 455 IPMLLYDPSKMPAFSRMMLQR-KIAVVVVAYPATPLIESRVRFCVSAALTKEDIDYLLRH 513
Query: 507 LDSVFNELSLSRIGDWEGKGGLCGVGEPDIEPIEHI 542
+D V ++L L G+ G G+P IE +
Sbjct: 514 VDEVGDKLFLKVSS---GRAGGSSDGKPPRWDIEEV 546
>|SAKL0H19272p (infer) YDR062W LCB2 Component of serine palmitoyltransferase
responsible along with Lcb1p for the first committed
step in sphingolipid synthesis which is the condensation
of serine with palmitoyl-CoA to form 3- ketosphinganine
: highly similar to uniprot|P40970 Saccharomyces
cerevisiae [Lachancea kluyveri]
Length = 562
Score = 126 bits (316), Expect = 8e-29, Method: Compositional matrix adjust.
Identities = 105/383 (27%), Positives = 178/383 (46%), Gaps = 39/383 (10%)
Query: 153 SNDYLGMGKNENTINEMK-RVLTKYGSGAGGTRNIAGHNIHALKLESELAALHKHEAALV 211
S +YLG ++E + + KYG +GG+R G + E +A A++
Sbjct: 161 SYNYLGFAQSEGQCTDAALECVDKYGIHSGGSRTQIGTTDLHIAAEEYVAGFVGKPDAII 220
Query: 212 FSSCFVANDAVLSLFGQKIKD--LVIFSDELNHASMIQGIRNSRAKKQVFKHNDLADLEE 269
FS + N + F I D ++ SDE NHAS+ G+R S A + FKHN+ LE+
Sbjct: 221 FSMGYGTN----ANFFNSILDSKCLVVSDEFNHASIRTGVRLSGAAVKTFKHNNTKALEK 276
Query: 270 KLA-QYPKSTPK--------LIAFESVYSMCGSIAPIEAICDLAEKYGALTFLDEVHAVG 320
+ Q + PK LIA E +YSM G++ + A+ +L +KY F+DE H++G
Sbjct: 277 LIRDQIVQGQPKSHRPWKKILIAVEGLYSMEGTMCNLPALIELKKKYKCYLFVDEAHSIG 336
Query: 321 MYGPHGAGVAEHLDFDAHLKSGIASPQTQTVMNRVDMVTGTLGKAYGTVGGYITGKANLI 380
GP G GV ++ D VD++ GTL K++G GGYI + ++I
Sbjct: 337 AIGPSGRGVCDYFGVDP---------------ADVDILMGTLTKSFGAAGGYIAAEKHII 381
Query: 381 DWFRSFAPGFIFTTTLPPSIMAGSSASIRYQRSTL-----QDRIAQ-QTNTRYVKNNLTD 434
D R + + P ++ +S+R L ++R+ + N+RY++ L
Sbjct: 382 DRLRLDLTTVNYGESAPAPVLGQIISSLRTIAGELNPGEGKERLQRIAYNSRYLRLALQR 441
Query: 435 IGIPVIP-NPSHIVPVLVGNALDAKKASDLLLDKYNIYVQAINFPTVPIGQERLRITPTP 493
+G V S ++P+L+ S ++L + I V + +P P+ + R+R +
Sbjct: 442 LGFIVYGIADSPVIPMLLYAPSKMPAFSRMMLQR-KIAVVVVAYPATPLIESRVRFCVSA 500
Query: 494 GHGPELSNQLIGALDSVFNELSL 516
E + L+ ++ V +L L
Sbjct: 501 ALTKEDIDYLLRHVNEVGEKLFL 523
>|SACE0D06688p Component of serine palmitoyltransferase, responsible along with
Lcb1p for the first committed step in sphingolipid
synthesis, which is the condensation of serine with
palmitoyl-CoA to form 3-ketosphinganine [Saccharomyces
cerevisiae]
Length = 561
Score = 126 bits (316), Expect = 9e-29, Method: Compositional matrix adjust.
Identities = 109/383 (28%), Positives = 177/383 (46%), Gaps = 39/383 (10%)
Query: 153 SNDYLGMGKNENTINEMK-RVLTKYGSGAGGTRNIAGHNIHALKLESELAALHKHEAALV 211
S +YLG +++ + + KY +GG R G +K E +A E ALV
Sbjct: 162 SYNYLGFAQSKGQCTDAALESVDKYSIQSGGPRAQIGTTDLHIKAEKLVARFIGKEDALV 221
Query: 212 FSSCFVANDAVLSLFGQKIKDLVIFSDELNHASMIQGIRNSRAKKQVFKHNDLADLEEKL 271
FS + N + + F K K LVI SDELNH S+ G+R S A + FKH D+ LE+ +
Sbjct: 222 FSMGYGTNANLFNAFLDK-KCLVI-SDELNHTSIRTGVRLSGAAVRTFKHGDMVGLEKLI 279
Query: 272 -AQYPKSTPK--------LIAFESVYSMCGSIAPIEAICDLAEKYGALTFLDEVHAVGMY 322
Q PK LI E ++SM G++ + + +L +KY F+DE H++G
Sbjct: 280 REQIVLGQPKTNRPWKKILICAEGLFSMEGTLCNLPKLVELKKKYKCYLFIDEAHSIGAM 339
Query: 323 GPHGAGVAEHLDFDAHLKSGIASPQTQTVMNRVDMVTGTLGKAYGTVGGYITGKANLIDW 382
GP G GV E D VD++ GT K++G GGYI +ID
Sbjct: 340 GPTGRGVCEIFGVDP---------------KDVDILMGTFTKSFGAAGGYIAADQWIIDR 384
Query: 383 FRSFAPGFIFTTTLPPSIMAGSSASIRY--------QRSTLQDRIAQQTNTRYVKNNLTD 434
R ++ ++P ++A + +S++ Q + RIA N+RY++ L
Sbjct: 385 LRLDLTTVSYSESMPAPVLAQTISSLQTISGEICPGQGTERLQRIA--FNSRYLRLALQR 442
Query: 435 IGIPVI-PNPSHIVPVLVGNALDAKKASDLLLDKYNIYVQAINFPTVPIGQERLRITPTP 493
+G V S ++P+L+ S ++L + I V + +P P+ + R+R +
Sbjct: 443 LGFIVYGVADSPVIPLLLYCPSKMPAFSRMMLQR-RIAVVVVAYPATPLIESRVRFCMSA 501
Query: 494 GHGPELSNQLIGALDSVFNELSL 516
E + L+ + V ++L+L
Sbjct: 502 SLTKEDIDYLLRHVSEVGDKLNL 524
>|KLLA0D02134p (infer) YDR062W LCB2 Component of serine palmitoyltransferase
responsible along with Lcb1p for the first committed
step in sphingolipid synthesis which is the condensation
of serine with palmitoyl-CoA to form 3- ketosphinganine
: highly similar to uniprot|P40970 Saccharomyces
cerevisiae [Kluyveromyces lactis NRRL Y-1140]
Length = 562
Score = 123 bits (308), Expect = 8e-28, Method: Compositional matrix adjust.
Identities = 111/395 (28%), Positives = 183/395 (46%), Gaps = 36/395 (9%)
Query: 153 SNDYLGMGKNENTINEMKRVLT-KYGSGAGGTRNIAGHNIHALKLESELAALHKHEAALV 211
S +YLG ++E T KYG +GG R G + E +A E A++
Sbjct: 161 SYNYLGFAQSEGQCTTAALEATDKYGVYSGGPRTRIGTTDLHVMTEKYVAQFVGKEDAIL 220
Query: 212 FSSCFVANDAVLSLFGQKIKDLVIFSDELNHASMIQGIRNSRAKKQVFKHNDLADLE--- 268
FS + N + F K LVI SD LNH S+ G+R S A + FKHND+ LE
Sbjct: 221 FSMGYGTNANFFNSFLDS-KCLVI-SDSLNHTSIRTGVRLSGAAVKTFKHNDMRALEKLI 278
Query: 269 -EKLAQYPKSTPK-----LIAFESVYSMCGSIAPIEAICDLAEKYGALTFLDEVHAVGMY 322
E++ Q T + +I E +YSM G++A + + +L +KY F+DE H++G
Sbjct: 279 REQIVQGQSKTHRPWKKIIICVEGLYSMEGTMANLPKLVELKKKYKCYLFVDEAHSIGAM 338
Query: 323 GPHGAGVAEHLDFDAHLKSGIASPQTQTVMNRVDMVTGTLGKAYGTVGGYITGKANLIDW 382
GP G GV + GI + +D++ GTL K++G GGYI +ID
Sbjct: 339 GPSGRGVCDFF--------GIPC-------SDIDIMMGTLTKSFGAAGGYIAADKWIIDR 383
Query: 383 FRSFAPGFIFTTTLPPSIMAGSSASIRYQRSTL-----QDRIAQ-QTNTRYVKNNLTDIG 436
FR + P ++A ++S++ + Q+R+ + N RY++ L +G
Sbjct: 384 FRLDLTTPHYGEPTPAPVLAQIASSLKTITGDINPGEGQERLQRIAFNARYLRLALQRLG 443
Query: 437 IPVIP-NPSHIVPVLVGNALDAKKASDLLLDKYNIYVQAINFPTVPIGQERLRITPTPGH 495
V S ++P+L+ S ++L + I V + +P P+ + R+R +
Sbjct: 444 FIVYGIADSPVIPMLLYAPSKMPAFSRMMLQR-KIAVVVVAYPATPLIESRVRFCVSAAL 502
Query: 496 GPELSNQLIGALDSVFNELSLSRIGDWEGKGGLCG 530
E + L+ ++ V ++L L ++ + G L G
Sbjct: 503 TKEDIDYLLQHINEVGDKLFL-KVSSGKAGGSLDG 536
>|CAGL0G05071p (infer) YDR062w LCB2 serine C-palmitoyltransferase subunit : highly
similar to uniprot|P40970 Saccharomyces cerevisiae
[Candida glabrata CBS 138]
Length = 565
Score = 117 bits (294), Expect = 3e-26, Method: Compositional matrix adjust.
Identities = 105/383 (27%), Positives = 173/383 (45%), Gaps = 39/383 (10%)
Query: 153 SNDYLGMGKNENTINEMK-RVLTKYGSGAGGTR-NIAGHNIHALKLESELAALHKHEAAL 210
S +YLG +++ + + KYG GG+R I ++H L E +A E A+
Sbjct: 166 SYNYLGFAQSKGQCTDAALESVDKYGIHTGGSRTQIGTTDLHRLT-EELVADFVGKEDAM 224
Query: 211 VFSSCFVANDAVLSLFGQKIKDLVIFSDELNHASMIQGIRNSRAKKQVFKHNDLADLEEK 270
VFS + N + F + K LVI SDELNH S+ G+R S A + FKH D+ LE+
Sbjct: 225 VFSMGYGTNANFFNAFLDR-KCLVI-SDELNHTSIRTGVRLSGAAVRTFKHGDMEGLEKL 282
Query: 271 LA-QYPKSTPK--------LIAFESVYSMCGSIAPIEAICDLAEKYGALTFLDEVHAVGM 321
+ Q PK LI E ++SM G++ + + L +KY F+DE H++G
Sbjct: 283 IRDQIVLGQPKTNRPWKKILICVEGLFSMEGTMCNLPELIALKKKYKCYLFVDEAHSIGA 342
Query: 322 YGPHGAGVAEHLDFDAHLKSGIASPQTQTVMNRVDMVTGTLGKAYGTVGGYITGKANLID 381
GP G GV E+ + H VD++ GT K++G GGYI ++D
Sbjct: 343 IGPTGRGVCEYFGVNPH---------------DVDILMGTFTKSFGAAGGYIATDKWVMD 387
Query: 382 WFRSFAPGFIFTTTLPPSIMAGSSASIRYQRSTL--------QDRIAQQTNTRYVKNNLT 433
R + P ++A +S+R + + +RIA + +
Sbjct: 388 RLRLDLTTTSYAEPTPAPVLAQIVSSLRTIKGDICPGEGRERLERIAFNSRYLRLALLRL 447
Query: 434 DIGIPVIPNPSHIVPVLVGNALDAKKASDLLLDKYNIYVQAINFPTVPIGQERLRITPTP 493
+ IP+ S ++P+L+ S ++L + I V + +P P+ + R+R +
Sbjct: 448 GFIVYGIPD-SPVIPMLLYCPSKMPAFSRMMLQR-KIAVVVVAYPATPLIESRVRFCMSA 505
Query: 494 GHGPELSNQLIGALDSVFNELSL 516
E + L+ +D V +L+L
Sbjct: 506 SITKEDIDYLLRHVDEVGEKLNL 528
>|YALI0E17545p (infer) YDR232w HEM1 5-aminolevulinate synthase : weakly similar to
uniprot|P09950 Saccharomyces cerevisiae [Yarrowia
lipolytica CLIB122]
Length = 393
Score = 115 bits (289), Expect = 1e-25, Method: Compositional matrix adjust.
Identities = 104/354 (29%), Positives = 161/354 (45%), Gaps = 36/354 (10%)
Query: 151 WCSNDYLGMGKNENTINEMKRVLTKYGSGAGGTRNIA------GHNIHALKLESELAALH 204
+ SND+L +GK + + + + + + + G+ LE ++AA H
Sbjct: 32 FSSNDFLSLGKYQPFKDSVSVKVADFCAQTSSSLGSGGSRLLDGNCALYEGLERQIAAFH 91
Query: 205 KHEAALVFSSCFVANDAVLSLFGQKIKDLVIFSDELNHASMIQGIRNSRAKKQV-FKHND 263
++ L+F+S F AN S Q +D+VI+ DEL HAS+ +G+R RAKK+V FKHND
Sbjct: 92 GAKSGLIFNSGFDANSGFFSCLPQP-QDIVIY-DELIHASVHEGMRQCRAKKRVLFKHND 149
Query: 264 LADLEEKLAQYP-KSTPKLIAFESVYSMCGSIAPIEAICDLAEKYG--ALTFLDEVHAVG 320
+ D E L QY +S +A E+VYSM G AP+ + D++++ L +DE HA G
Sbjct: 150 VEDFERVLNQYKGESGNIFVAVEAVYSMDGDTAPLRQLYDVSDRLNREILLVVDEAHATG 209
Query: 321 MYGPHGAGVAEHLDFDAHLKSGIASPQTQTVMNRVDMVTGTLGKAYGTVGGYITGKANLI 380
+ G G G+ L + + V R+ T GKA G I +
Sbjct: 210 VLGDQGRGLVCALGME------------KQVFARIH----TFGKALSANGAIILCHPVVR 253
Query: 381 DWFRSFAPGFIFTTTLPPSIMAGSSASIRYQRSTLQDRIAQQT--NTRYVKNNLTDIGIP 438
+ ++A FIFTT L + A+ + + Q N + L D G+
Sbjct: 254 SYLINYARSFIFTTALGQVNLLIIQATYELLETQAAAHLQTQLWDNLQRFSTGLKDTGVH 313
Query: 439 VIP--NPSHIVPVLVGNALDAKKASDLLLDKYNIYVQAINFPTVPIGQERLRIT 490
V P S I V N ++ + + V+ I PTVP G ER+R+
Sbjct: 314 VYPPVPRSAIFSVFCDNP----RSLAAHCQQSGLVVRPIVHPTVPKGTERVRVC 363
>|KLLA0A09955p (infer) YMR296C LCB1 Component of serine palmitoyltransferase
responsible along with Lcb2p for the first committed
step in sphingolipid synthesis : similar to
uniprot|P25045 Saccharomyces cerevisiae [Kluyveromyces
lactis NRRL Y-1140]
Length = 555
Score = 107 bits (266), Expect = 5e-23, Method: Compositional matrix adjust.
Identities = 70/290 (24%), Positives = 135/290 (46%), Gaps = 29/290 (10%)
Query: 152 CSNDYLGMGKNENTINEMKRVLTKYGSGAGGTRNIAGHNIHALKLESELAALHKHEAALV 211
CS ++L + K+ + K ++ YG G+ G G+ LE +LA+ E +++
Sbjct: 150 CSFNFLQLSKHPRVVEIAKEIIKNYGVGSCGPAGFYGNEDVHYNLEYDLASFFGTENSVL 209
Query: 212 FSSCFVANDAVLSLFGQKIKDLVIFSDELNHASMIQGIRNSRAKKQVFKHNDLADLE--- 268
+ F + +V+ F ++ D+++ D+++ +S ++ SR+ +KHND+A LE
Sbjct: 210 YGQDFCVSSSVIPAFTKR-GDVIVADDKISVSSQ-NALQLSRSTVYYYKHNDMASLENLL 267
Query: 269 ------EKLAQYPKSTPKLIAFESVYSMCGSIAPIEAICDLAEKYGALTFLDEVHAVGMY 322
EK + P K I E ++ G IAP+ + L KY F+DE ++G+
Sbjct: 268 HELDEAEKKEKLPAIPRKFIVTEGIFHRTGEIAPLPELVQLKRKYKYRLFIDETFSIGVL 327
Query: 323 GPHGAGVAEHLDFDAHLKSGIASPQTQTVMNRVDMVTGTLGKAYGTVGGYITGKANLIDW 382
G G G+ E+ + + +D+ G+L A G+ GG++ G ++
Sbjct: 328 GATGRGLTEYYNINR--------------ATSIDITVGSLATAIGSSGGFVLGDNVMVRH 373
Query: 383 FRSFAPGFIFTTTLPPSIMAGSSASIRYQRSTLQDRIAQQTNTRYVKNNL 432
R + + F+ +LPP + +S ++ + + + T RY+ N L
Sbjct: 374 QRIGSNAYCFSASLPPYAVRTASTVLQ----MMDEDNSSVTKLRYLSNKL 419
>|SAKL0H01144p (infer) cerevisiae LCB1 Component of serine palmitoyltransferase
responsible along with Lcb2p for the first committed
step in sphingolipid synthesis : similar to
uniprot|P25045 YMR296C Saccharomyces [Lachancea
kluyveri]
Length = 550
Score = 100 bits (249), Expect = 5e-21, Method: Compositional matrix adjust.
Identities = 69/258 (26%), Positives = 119/258 (46%), Gaps = 31/258 (12%)
Query: 153 SNDYLGMGKNENTINEMKRVLTKYGSGAGGTRNIAGHNIHALKLESELAALHKHEAALVF 212
SN++L + +N + +NE+K+ + YG GA G G+ LE +LA E A+++
Sbjct: 148 SNNFLQLSENPSVLNEVKKTIKNYGVGACGPAGFYGNQDVHNTLEYDLARFFGTENAVLY 207
Query: 213 SSCFVANDAVLSLFGQKIKDLVIFSDELNHASMIQGIRNSRAKKQVFKHNDLADLEEKLA 272
F +VL F ++ LV +D+ S+ ++ +R+ F+HND+ LE L
Sbjct: 208 GQDFCVAASVLPAFTKRGDVLV--ADDGVSISLQNALQLARSTVYYFRHNDMDSLESLLR 265
Query: 273 QY---------PKSTPKLIAFESVYSMCGSIAPIEAICDLAEKYGALTFLDEVHAVGMYG 323
+ P + I E ++ G IAP+ + L KY F+DE +++G+ G
Sbjct: 266 ELNEREERDRSPALPRRFIVTEGLFHNSGDIAPLPQLVRLKSKYKYRLFIDETYSLGVLG 325
Query: 324 PHGAGVAEHLDFDAHLKSGIASPQTQTVMNR---VDMVTGTLGKAYGTVGGYITGKANLI 380
G G+ EH + MNR VD+ G++ A G+ G ++ G +
Sbjct: 326 STGRGLTEHFN-----------------MNRDKVVDITLGSMATALGSSGAFVLGDNVMS 368
Query: 381 DWFRSFAPGFIFTTTLPP 398
R + + F+ +LPP
Sbjct: 369 HHQRIGSAAYCFSASLPP 386
>|CAGL0G00440p (infer) YMR296c LCB1 serine C-palmitoyltransferase subunit :
similar to uniprot|P25045 Saccharomyces cerevisiae
[Candida glabrata CBS 138]
Length = 558
Score = 97.8 bits (242), Expect = 3e-20, Method: Compositional matrix adjust.
Identities = 67/271 (24%), Positives = 127/271 (46%), Gaps = 25/271 (9%)
Query: 136 FPKAHRSEENDKVTVWCSNDYLGMGKNENTINEMKRVLTKYGSGAGGTRNIAGHNIHALK 195
F +++ E + V +N++L + K E +N K + YG GA G G+
Sbjct: 139 FTRSNGKETFENVLNMSTNNFLQLSKTERVVNTAKTTIKNYGVGACGPAGFYGNQDVHYH 198
Query: 196 LESELAALHKHEAALVFSSCFVANDAVLSLFGQKIKDLVIFSDELNHASMIQGIRNSRAK 255
LE ELA ++A+++ F +V+ F ++ D+++ ++++ A + ++ SR+
Sbjct: 199 LEYELAKFFGTDSAVLYGQDFCVAASVIPAFTKR-GDILVADNDVSLA-VQNALQLSRST 256
Query: 256 KQVFKHNDLADLEEKLAQY--------PKSTP-KLIAFESVYSMCGSIAPIEAICDLAEK 306
++HN++ LE LA+ P + P K I E++++ G IAP+ + L K
Sbjct: 257 VYYYEHNNMESLENLLAELTEAEKKDKPPAIPRKFIVTEAIFTNTGDIAPLPELTKLKRK 316
Query: 307 YGALTFLDEVHAVGMYGPHGAGVAEHLDFDAHLKSGIASPQTQTVMNRVDMVTGTLGKAY 366
Y F+DE ++G+ G G G+ EH + D +D+ G+L A
Sbjct: 317 YKFRLFVDETLSLGVLGASGRGLPEHFNMDR--------------ARSIDITVGSLANAL 362
Query: 367 GTVGGYITGKANLIDWFRSFAPGFIFTTTLP 397
G+ GG++ G + + + F+ +LP
Sbjct: 363 GSSGGFVLGDHVMSQHQHIGSNAYCFSASLP 393
>|SACE0M10164p Component of serine palmitoyltransferase, responsible along with
Lcb2p for the first committed step in sphingolipid
synthesis, which is the condensation of serine with
palmitoyl-CoA to form 3-ketosphinganine [Saccharomyces
cerevisiae]
Length = 558
Score = 97.8 bits (242), Expect = 3e-20, Method: Compositional matrix adjust.
Identities = 66/270 (24%), Positives = 120/270 (44%), Gaps = 25/270 (9%)
Query: 153 SNDYLGMGKNENTINEMKRVLTKYGSGAGGTRNIAGHNIHALKLESELAALHKHEAALVF 212
SN++L + E +K + YG GA G G+ LE +LA + ++++
Sbjct: 152 SNNFLQLSATEPVKEVVKTTIKNYGVGACGPAGFYGNQDVHYTLEYDLAQFFGTQGSVLY 211
Query: 213 SSCFVANDAVLSLFGQKIKDLVIFSDELNHASMIQGIRNSRAKKQVFKHNDLADLE---- 268
F A +VL F ++ D+++ D+++ + ++ SR+ F HND+ LE
Sbjct: 212 GQDFCAAPSVLPAFTKR-GDVIVADDQVS-LPVQNALQLSRSTVYYFNHNDMNSLECLLN 269
Query: 269 -----EKLAQYPKSTPKLIAFESVYSMCGSIAPIEAICDLAEKYGALTFLDEVHAVGMYG 323
EKL + P K I E ++ G +AP+ + L KY F+DE ++G+ G
Sbjct: 270 ELTEQEKLEKLPAIPRKFIVTEGIFHNSGDLAPLPELTKLKNKYKFRLFVDETFSIGVLG 329
Query: 324 PHGAGVAEHLDFDAHLKSGIASPQTQTVMNRVDMVTGTLGKAYGTVGGYITGKANLIDWF 383
G G++EH + D +D+ G++ A G+ GG++ G + +
Sbjct: 330 ATGRGLSEHFNMDR--------------ATAIDITVGSMATALGSTGGFVLGDSVMCLHQ 375
Query: 384 RSFAPGFIFTTTLPPSIMAGSSASIRYQRS 413
R + + F+ LP + S ++ S
Sbjct: 376 RIGSNAYCFSACLPAYTVTSVSKVLKLMDS 405
>|YALI0C03179p (infer) Serine palmitoyl CoA transferase subunit LCBA : similar to
uniprot|Q96VQ7 Emericella nidulans [Yarrowia lipolytica
CLIB122]
Length = 545
Score = 94.0 bits (232), Expect = 4e-19, Method: Compositional matrix adjust.
Identities = 71/289 (24%), Positives = 137/289 (47%), Gaps = 26/289 (8%)
Query: 147 KVTVWCSNDYLGMGKNENTINEMKRVLTKYGSGAGGTRNIAGHNIHALKLESELAALHKH 206
+ T S D+LG ++ +++ +YG G+ G G+ +K E +LA
Sbjct: 155 RATNLASTDFLGWARDPVIKERAVQIIREYGVGSCGPPGFYGNQDIHVKCERDLARFCNS 214
Query: 207 EAALVFSSCFVANDAVLSLFGQKIKDLVIFSDELNHASMIQGIRNSRAKKQVFKHNDLAD 266
E+A++++ F +V+ F ++ D+VI D + S +G++ SR + +KHND+ D
Sbjct: 215 ESAILYAQAFNTMSSVIPSFMKR-GDIVIADDRVA-TSTQKGLQVSRVTLRWYKHNDMED 272
Query: 267 LEEKLA----QYPKS--TPKLIAFESVYSMCGSIAPIEAICDLAEKYGALTFLDEVHAVG 320
L LA ++ K+ T + I E ++ G + + I L ++ LDE + G
Sbjct: 273 LARVLAKTNHEFRKAPLTKRFIVTEGLFENTGDLCNLPEIIKLKYQFKYRLLLDESLSFG 332
Query: 321 MYGPHGAGVAEHLDFDAHLKSGIASPQTQTVMNRVDMVTGTLGKAYGTVGGYITGKANLI 380
+ G G GV EH + H P+ ++++ G++ A+ + GG++ G +
Sbjct: 333 LVGSTGRGVLEHFQENGH-------PELSR--QQIELTAGSMAIAFSSAGGFVAGSDAAV 383
Query: 381 DWFRSFAPGFIFTTTLPPSIMAGSSASIRYQRSTLQDRIAQQTNTRYVK 429
+ R + F+ ++P + A SS +I +R+ ++ N+R VK
Sbjct: 384 EHQRIGSNAVTFSASMPGYLAAASSQAI--------ERL-EEDNSRVVK 423
>|ZYRO0D07282p (infer) cerevisiae LCB1 Component of serine palmitoyltransferase
responsible along with Lcb2p for the first committed
step in sphingolipid synthesis : similar to
uniprot|P25045 YMR296C Saccharomyces [Zygosaccharomyces
rouxii]
Length = 553
Score = 90.1 bits (222), Expect = 6e-18, Method: Compositional matrix adjust.
Identities = 73/322 (22%), Positives = 140/322 (43%), Gaps = 33/322 (10%)
Query: 127 NNINRLANEFPKAHRSEENDKVTVWCSNDYLGMGKNENTINEMKRVLTKYGSGAGGTRNI 186
N IN N ++++ V SN++L + + + + V+ YG GA G
Sbjct: 131 NRINIFQN-------GKKHENVLNLSSNNFLHLSQTPRVQDVARSVIKNYGVGACGPAGF 183
Query: 187 AGHNIHALKLESELAALHKHEAALVFSSCFVANDAVLSLFGQKIKDLVIFSDELNHASMI 246
G+ LE L+ E+A+++ F + +V+ F ++ DL++ +DE ++
Sbjct: 184 YGNQDVHYNLEYRLSDFFGTESAVLYGQDFCTSASVIPAFTKR-GDLLV-ADEKVSLAVQ 241
Query: 247 QGIRNSRAKKQVFKHNDLADLE---------EKLAQYPKSTPKLIAFESVYSMCGSIAPI 297
++ SR+ ++HN++ LE EK P + K I E ++ G I P+
Sbjct: 242 NALQLSRSTVYYYEHNNMESLEAILSELVESEKKENLPAISRKFIVTEGIFQNTGDIPPL 301
Query: 298 EAICDLAEKYGALTFLDEVHAVGMYGPHGAGVAEHLDFDAHLKSGIASPQTQTVMNRVDM 357
+ +L KY F+DE ++G+ G G G+ E+ P+ ++ +D+
Sbjct: 302 PQLFELKNKYKFRLFVDETLSLGVLGKSGRGLTEYFGL----------PRKES----IDI 347
Query: 358 VTGTLGKAYGTVGGYITGKANLIDWFRSFAPGFIFTTTLPPSIMAGSSASIRYQRSTLQD 417
G++ A+G+ G ++ G A + R + + F+ +LPP +R
Sbjct: 348 TVGSMAHAFGSSGAFVLGDAVMSHHQRIGSYAYCFSASLPPYTARSVDEVLRILEEDNSS 407
Query: 418 RIAQQTNTRYVKNN-LTDIGIP 438
Q ++ + N LTD +P
Sbjct: 408 VTKLQKFSKLLHNEFLTDAKLP 429
>|DEHA2E02134p (infer) YMR296C LCB1 Component of serine palmitoyltransferase
responsible along with Lcb2p for the first committed
step in sphingolipid synthesis which is the condensation
of serine with palmitoyl-CoA to form 3-ketosphinganine :
similar to uniprot|P25045 Saccharomyces cerevisiae
[Debaryomyces hansenii CBS767]
Length = 581
Score = 89.0 bits (219), Expect = 1e-17, Method: Compositional matrix adjust.
Identities = 74/292 (25%), Positives = 136/292 (46%), Gaps = 29/292 (9%)
Query: 131 RLANEFPKAHRSEENDKVTVWCSNDYLGMGKNENTINEMKRVLTKYGSGAGGTRNIAGHN 190
+L NE P +H KV S D+L + +++N K ++ G GA G N G
Sbjct: 141 QLLNE-PGSHLG----KVVNLASYDFLNLNESDNIKAAAKGCISGAGVGACGPPNFYGTQ 195
Query: 191 IHALKLESELAALHKHEAALVFSSCFVANDAVLSLFGQKIKDLVIFSDELNHASMIQGIR 250
++LE +L+ E A+++ FV +V+ + ++ DL I +N A + + +
Sbjct: 196 DVHVRLEEDLSEYLGTEQAILYGQDFVTAGSVIPAYLKR-GDLCIVDSGVNLA-IQKALI 253
Query: 251 NSRAKKQVFKHNDLADLEEKLAQYP----KSTP---KLIAFESVYSMCGSIAPIEAICDL 303
SR + + HND+ LE+ L + K P + + ES+++ G +A + I +L
Sbjct: 254 VSRCDLEWYDHNDMDHLEQILKEIKPVIEKQKPIRRRFVVTESLFATTGDLALLPRIVEL 313
Query: 304 AEKYGALTFLDEVHAVGMYGPHGAGVAEHLDFDAHLKSGIASPQTQTVMNRVDMVTGTLG 363
KY FLDE ++G+ G G G+ EH + P+++ + + G++
Sbjct: 314 KNKYKYRLFLDESLSIGVLGATGKGLVEHYNI----------PRSE-----ISITIGSMA 358
Query: 364 KAYGTVGGYITGKANLIDWFRSFAPGFIFTTTLPPSIMAGSSASIRYQRSTL 415
++ + GG+ G +I R + ++F+ LPP +S +I+ S L
Sbjct: 359 LSFASSGGFCVGVTPMIQHQRISSNAYVFSAALPPYSAKVTSEAIKEISSNL 410
>|ERGO0B08624p Syntenic homolog of Saccharomyces cerevisiae YMR296C (LCB1)
[Eremothecium gossypii]
Length = 550
Score = 82.8 bits (203), Expect = 1e-15, Method: Compositional matrix adjust.
Identities = 61/254 (24%), Positives = 116/254 (45%), Gaps = 25/254 (9%)
Query: 165 TINEMKRVLTKYGSGAGGTRNIAGHNIHALKLESELAALHKHEAALVFSSCFVANDAVLS 224
+ +++ + YG G+ G G+ LE ELA E A+++ F +V+
Sbjct: 157 VVARVEKTIRNYGVGSCGPAGFYGNQDLHYNLEYELARFFGTENAVLYGQDFCVASSVIP 216
Query: 225 LFGQKIKDLVIFSDELNHASMIQGIRNSRAKKQVFKHNDLADLEEKLAQY---------P 275
F ++ D+++ D+++ ++ ++ SR+ FKHND+ LEE L + P
Sbjct: 217 AFTKR-GDVIVADDQVS-VALQNALQLSRSTVYYFKHNDMKSLEELLTKLDERDRAEHLP 274
Query: 276 KSTPKLIAFESVYSMCGSIAPIEAICDLAEKYGALTFLDEVHAVGMYGPHGAGVAEHLDF 335
K I E ++ G IAP+ + L + +DE +++G+ G G G++EH F
Sbjct: 275 ALPRKFIVTEGLFQNSGDIAPLPELVKLKGAFHYRLVVDETNSLGVLGNTGRGLSEH--F 332
Query: 336 DAHLKSGIASPQTQTVMNRVDMVTGTLGKAYGTVGGYITGKANLIDWFRSFAPGFIFTTT 395
+ S I D+ G++ A G+ GG++ G + R + + ++ +
Sbjct: 333 NVQRCSSI------------DITIGSMATALGSSGGFVLGDNVMSRHQRIGSNAYCYSAS 380
Query: 396 LPPSIMAGSSASIR 409
LP AG+ A ++
Sbjct: 381 LPAYTCAGALAMLQ 394
>|KLTH0B09306p (infer) cerevisiae LCB1 Component of serine palmitoyltransferase
responsible along with Lcb2p for the first committed
step in sphingolipid synthesis : similar to
uniprot|P25045 YMR296C Saccharomyces [Kluyveromyces
thermotolerans]
Length = 552
Score = 73.9 bits (180), Expect = 5e-13, Method: Compositional matrix adjust.
Identities = 63/261 (24%), Positives = 115/261 (44%), Gaps = 39/261 (14%)
Query: 153 SNDYLGMGKNENTINEMKRVLTKYGSGAGGTRNIAG-HNIHALKLESELAALHKHEAALV 211
S +L + + + K + +YG GA G G ++H+ +LE LA E A++
Sbjct: 149 STSFLQISSDPEFVKAAKDTIHQYGVGACGPAGFYGNQDVHS-ELEYNLARFFGTERAVL 207
Query: 212 FSSCFVANDAVLSLFGQKIKDLVIFSDELNHASMIQGIRNSRAKKQVFKHNDL------- 264
+ F +V+ F ++ D+++ D +N ++ ++ SR+ + HND+
Sbjct: 208 YGQDFCIAASVIPAFTKR-GDVIVADDRVN-VALQNALQLSRSTVYYYNHNDMEALEELL 265
Query: 265 -----ADLEEKLAQYPKSTPKLIAFESVYSMCGSIAPIEAICDLAEKYGALTFLDEVHAV 319
+L EKL P+ K I E ++ G I + + +L KY +DE ++
Sbjct: 266 EQLQERELNEKLPSLPR---KFIVTEGLFQNLGDIPDLPRLVELKRKYKYRLLVDETFSL 322
Query: 320 GMYGPHGAGVAEHLDFDAHLKSGIASPQTQTVMNR---VDMVTGTLGKAYGTVGGYITGK 376
G+ G +G G+AE+ + M R VD+ G+L A G+ GG++ G
Sbjct: 323 GVLGANGRGIAEYYN-----------------MKRDASVDITIGSLAVALGSSGGFVLGD 365
Query: 377 ANLIDWFRSFAPGFIFTTTLP 397
+ R + + F+ LP
Sbjct: 366 NVMSMHQRIGSHAYTFSAALP 386
BLASTP 2.2.18 [Mar-02-2008]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for compositional score matrix adjustment: Altschul, Stephen F.,
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.
URL: http://www.genolevures.org/elt/DEHA/DEHA2B05478p/gl3_blastp/DEHA2B05478p.html